Estrogen receptor beta (ESR2) is a 530-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q92731.
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The mean pLDDT of this model is 69.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 40% |
What pLDDT means and how to read it
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560)
Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with UBE1C. Interacts with AKAP13. Interacts with DNTTIP2. Interacts with isoform 4 of TXNRD1. Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3OLL | X-ray | 1.5 Å | A/B=261-500 |
| 7XVY | X-ray | 1.54 Å | A/B=261-500 |
| 1QKM | X-ray | 1.8 Å | A=255-509 |
| 7XWQ | X-ray | 1.89 Å | A/B=261-500 |
| 7XWP | X-ray | 1.92 Å | A/B=261-500 |
| 2YJD | X-ray | 1.93 Å | A/B=261-500 |
| 3OMQ | X-ray | 1.97 Å | A/B=261-500 |
| 9ECF | X-ray | 2.0 Å | A/B/E/F/I/J/M/N=261-500 |
| 1YYE | X-ray | 2.03 Å | A/B=263-530 |
| 3OMP | X-ray | 2.05 Å | A/B=261-500 |
| 7XVZ | X-ray | 2.08 Å | A/B=261-500 |
| 2NV7 | X-ray | 2.1 Å | A/B=263-500 |
| 4J24 | X-ray | 2.1 Å | A/B/C/D=261-500 |
| 4ZI1 | X-ray | 2.1 Å | A=262-509 |
| 7XWR | X-ray | 2.16 Å | A/B=261-500 |
| 1X76 | X-ray | 2.2 Å | A/B=261-500 |
| 1ZAF | X-ray | 2.2 Å | A/B=263-500 |
| 2FSZ | X-ray | 2.2 Å | A/B=257-502 |
| 2GIU | X-ray | 2.2 Å | A=260-500 |
| 3OLS | X-ray | 2.2 Å | A/B=261-500 |
Showing 20 of 39 experimental structures (best resolution first).
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