Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069. Determined by X-ray diffraction at 2.1 Å resolution. Released 4 May 2011.
Explore 3RI1 in 3D Show helices and sheets RCSB PDB PDBe
3RI1 contains 33 α-helices and 28 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 475 | 1 | 1 |
| α-helix | 478-480 | 3 | |
| β-strand | 481-487 | 7 | 1 |
| β-strand | 494-501 | 8 | 1 |
| β-strand | 511-518 | 8 | 1 |
| β-strand | 524 | 1 | 2 |
| α-helix | 525-540 | 16 | |
| β-strand | 547 | 1 | 3 |
| β-strand | 550-554 | 5 | 1 |
| β-strand | 561-565 | 5 | 1 |
| β-strand | 571 | 1 | 3 |
| α-helix | 572-578 | 7 | |
| α-helix | 597-599 | 3 | |
| α-helix | 600-619 | 20 | |
| β-strand | 622-623 | 2 | 4 |
| α-helix | 629-631 | 3 | |
| β-strand | 632-634 | 3 | 3 |
| β-strand | 640-642 | 3 | 3 |
| β-strand | 649-650 | 2 | 4 |
| β-strand | 666 | 1 | 5 |
| α-helix | 667-669 | 3 | |
| α-helix | 672-676 | 5 | |
| α-helix | 682-697 | 16 | |
| α-helix | 701-702 | 2 | |
| α-helix | 709-717 | 9 | |
| α-helix | 722-725 | 4 | |
| α-helix | 730-739 | 10 | |
| α-helix | 744-746 | 3 | |
| α-helix | 748-749 | 2 | |
| α-helix | 750-764 | 15 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 475 | 1 | 6 |
| α-helix | 478-480 | 3 | |
| β-strand | 481-487 | 7 | 6 |
| β-strand | 494-501 | 8 | 6 |
| β-strand | 511-518 | 8 | 6 |
| β-strand | 524 | 1 | 5 |
| α-helix | 525-540 | 16 | |
| β-strand | 547 | 1 | 7 |
| β-strand | 550-554 | 5 | 6 |
| β-strand | 561-565 | 5 | 6 |
| β-strand | 571 | 1 | 7 |
| α-helix | 572-577 | 6 | |
| α-helix | 597-599 | 3 | |
| α-helix | 600-619 | 20 | |
| β-strand | 622-623 | 2 | 8 |
| α-helix | 629-631 | 3 | |
| β-strand | 632-634 | 3 | 7 |
| β-strand | 640-642 | 3 | 7 |
| β-strand | 649-650 | 2 | 8 |
| β-strand | 666 | 1 | 2 |
| α-helix | 667-669 | 3 | |
| α-helix | 672-676 | 5 | |
| α-helix | 682-697 | 16 | |
| α-helix | 701-702 | 2 | |
| α-helix | 709-711 | 3 | |
| α-helix | 712-717 | 6 | |
| α-helix | 722-725 | 4 | |
| α-helix | 730-739 | 10 | |
| α-helix | 744-746 | 3 | |
| α-helix | 748-749 | 2 | |
| α-helix | 750-765 | 16 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 | A, B | protein | 313 | Homo sapiens | P21802 (AlphaFold model) |
>3RI1_1 Fibroblast growth factor receptor 2 (chains A, B) GSPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVA VKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREY LRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT ENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWE IFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE DLDRILTLTTNEE
| ID | Name | Formula | Copies |
|---|---|---|---|
| 3RH | (6S)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine | C18 H15 N3 | 2 |
Water and common crystallization additives (SO4) are not listed.
A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor. Eathiraj, S., Palma, R., Hirschi, M. et al. J Biol Chem (2011) 286:20677-20687. DOI 10.1074/jbc.M110.213736 · PubMed
Other PDB entries of the same protein (UniProt P21802 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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