4CFG: TRIM25 coiled-coil

Structure of the TRIM25 coiled-coil. Determined by X-ray diffraction at 2.8 Å resolution. Released 10 Dec 2014.

Method: X-ray diffraction
Resolution: 2.8 Å
Organism: HOMO SAPIENS
Chains: 2
Atoms: 2,669
Mol. weight: 142.9 kDa
Released: 10 Dec 2014

Explore 4CFG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4CFG contains 7 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	195-301	107
α-helix	304-314	11
α-helix	321-322	2
α-helix	331-354	24

Chain B: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	197-300	104
α-helix	305-315	11
α-helix	331-355	25

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
E3 UBIQUITIN/ISG15 ligase TRIM25	A, B	protein	630	HOMO SAPIENS	Q14258 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>4CFG_1 E3 UBIQUITIN/ISG15 LIGASE TRIM25 (chains A, B)
MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVYQAR
PQLHKNTVLCNVVEQFLQADLAREPPADVWTPPARASAPSPNAQVACDHCLKEAAVKTCL
VCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICHICL
VEHKTCSPASLSQASADLEATLRHKLTVMYSQINGASRALDDVRNRQQDVRMTANRKVEQ
LQQEYTEMKALLDASETTSTRKIKEEEKRVNSQFDTIYQILLKKKSEIQTLKEEIEQSLT
KRDEFEFLEKASKLRGISTQPVYIPEVELNHKLIKGIHQSTIDLKNELKQCIGRLQEPTP
SSGDPGEHDPASTHKSTRPVKKVSKEEKKSKKPPPVPALPSKLPTFGAPEQLVDLKQAGL
EAAAKATSSHPNSTSLKAKVLETFLAKSRPELLEYYIKVILDYNTAHNKVALSECYTVAS
VAEMPQNYRPHPQRFTYCSQVLGLHCYKKGIHYWEVELQKNNFCGVGICYGSMNRQGPES
RLGRNSASWCVEWFNTKISAWHNNVEKTLPSTKATRVGVLLNCDHGFVIFFAVADKVHLM
YKFRVDFTEALYPAFWVFSAGATLSICSPK

Primary citation

Structure of the Trim25 Coiled-Coil. James, L. To be published.

Other PDB entries of the same protein (UniProt Q14258 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9I0T 1.8 Å, Crystal structure of TRIM25 PRYSPRY covalently bound to…
6FLM 2.01 Å, Crystal structure of the human TRIM25 PRYSPRY domain
5FER 2.34 Å, Complex of TRIM25 RING with UbcH5-Ub
5EYA 2.4 Å, TRIM25 RING domain in complex with Ubc13-Ub conjugate
4LTB 2.59 Å, Coiled-coil domain of TRIM25
9IUN 2.7 Å, Crystal structure of Trim25 Pspry
5NT1 2.82 Å, Complex of influenza A NS1 effector domain with TRIM25 coiled coil
6FLN 3.6 Å, Crystal structure of the human TRIM25 coiled-coil and PRYSPRY domains
5NT2 4.26 Å, Complex of influenza A NS1 with TRIM25 coiled coil domain

Browse structure collections

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