Crystal structure of the C-terminus of voltage-gated sodium channel in complex with FGF13 and CaM. Determined by X-ray diffraction at 2.2 Å resolution. Released 27 Jun 2012.
Explore 4DCK in 3D Show helices and sheets RCSB PDB PDBe
4DCK contains 23 α-helices and 22 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 1777 | 1 | 1 |
| β-strand | 1786 | 1 | 1 |
| α-helix | 1788-1801 | 14 | |
| β-strand | 1808-1810 | 3 | 2 |
| α-helix | 1811-1813 | 3 | |
| α-helix | 1814-1820 | 7 | |
| α-helix | 1822 | 1 | |
| α-helix | 1828 | 1 | |
| α-helix | 1832-1837 | 6 | |
| β-strand | 1841-1843 | 3 | 2 |
| β-strand | 1847-1849 | 3 | 2 |
| α-helix | 1850-1862 | 13 | |
| α-helix | 1866-1882 | 17 | |
| α-helix | 1886-1888 | 3 | |
| β-strand | 1892-1895 | 4 | 2 |
| α-helix | 1896-1926 | 31 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 7-18 | 12 | |
| α-helix | 30-39 | 10 | |
| α-helix | 46-54 | 9 | |
| α-helix | 66-93 | 28 | |
| β-strand | 100-102 | 3 | 3 |
| α-helix | 103-112 | 10 | |
| α-helix | 116-118 | 3 | |
| α-helix | 119-129 | 11 | |
| β-strand | 136-138 | 3 | 3 |
| α-helix | 139-148 | 10 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 13-22 | 10 | 4 |
| β-strand | 26-30 | 5 | 4 |
| β-strand | 36-39 | 4 | 4 |
| β-strand | 49-55 | 7 | 4 |
| β-strand | 58-63 | 6 | 4 |
| α-helix | 68 | 1 | |
| β-strand | 69-72 | 4 | 4 |
| β-strand | 78-81 | 4 | 4 |
| α-helix | 86-88 | 3 | |
| β-strand | 90-95 | 6 | 4 |
| β-strand | 99-108 | 10 | 4 |
| β-strand | 115-117 | 3 | 4 |
| β-strand | 120 | 1 | 5 |
| β-strand | 125 | 1 | 4 |
| β-strand | 126 | 1 | 5 |
| α-helix | 129-131 | 3 | |
| α-helix | 137-139 | 3 | |
| β-strand | 141-151 | 11 | 4 |
| α-helix | 152-156 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Sodium channel protein type 5 subunit alpha | A | protein | 168 | Homo sapiens | Q14524 (AlphaFold model) |
| Calmodulin | B | protein | 149 | Homo sapiens | P0DP23 (AlphaFold model) |
| Fibroblast growth factor 13 | C | protein | 192 | Homo sapiens | Q92913 (AlphaFold model) |
>4DCK_1 Sodium channel protein type 5 subunit alpha (chains A) ENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQ ISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPI TTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEED
>4DCK_2 Calmodulin (chains B) MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE EVDEMIREADIDGDGQVNYEEFVQMMTAK
>4DCK_3 Fibroblast growth factor 13 (chains C) MALLRKSYSEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVA IQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGL NKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVL NGGKSMSHNEST
| ID | Name | Formula | Copies |
|---|---|---|---|
| MG | Magnesium ion | Mg | 3 |
Crystal Structure of the Ternary Complex of a NaV C-Terminal Domain, a Fibroblast Growth Factor Homologous Factor, and Calmodulin. Wang, C., Chung, B.C., Yan, H. et al. Structure (2012) 20:1167-1176. DOI 10.1016/j.str.2012.05.001 · PubMed
Other PDB entries of the same protein (UniProt Q14524 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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