9P24: Sodium channel protein type 5 subunit alpha

Structure of human cardiac sodium channel Nav1.5 in intermediate open state. Determined by electron microscopy at 3.48 Å resolution. Released 8 Apr 2026.

Method
Electron microscopy
Resolution
3.48 Å
Organism
Homo sapiens
Chains
1
Atoms
10,256
Mol. weight
229.49 kDa
Ligands
NAG, 9Z9
Released
8 Apr 2026

Explore 9P24 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9P24 contains 64 α-helices and 22 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 64 helices, 22 β-strands

ElementResiduesLengthSheet
α-helix18-3619
α-helix53-553
β-strand6311
α-helix64-652
β-strand8012
α-helix86-894
β-strand92-9323
β-strand9412
β-strand10111
β-strand105-10623
α-helix109-1102
α-helix119-12911
α-helix132-14615
α-helix157-17822
α-helix188-1903
α-helix193-20917
α-helix224-2274
α-helix236-24914
α-helix254-26916
β-strand278-28254
β-strand28515
β-strand295-29625
β-strand299-30025
α-helix304-3096
β-strand31616
α-helix3171
β-strand32316
β-strand339-34354
α-helix349-3513
α-helix358-37013
α-helix374-38411
α-helix390-40011
α-helix404-43835
α-helix703-71412
α-helix720-73415
β-strand73817
α-helix743-77533
α-helix780-79314
α-helix805-82016
α-helix823-83412
α-helix843-86018
α-helix863-8719
α-helix884-89613
α-helix901-91010
α-helix913-94230
α-helix959-97012
α-helix1189-120214
α-helix1205-122016
α-helix1221-12244
α-helix1236-126126
α-helix1263-12664
α-helix1270-129021
α-helix1297-13037
α-helix1304-131411
α-helix1318-132811
α-helix1332-135524
β-strand1361-136448
α-helix13711
β-strand137218
α-helix1373-13742
β-strand138019
α-helix1381-13866
β-strand1394-139748
β-strand140417
α-helix1405-141612
α-helix1421-14299
β-strand143619
α-helix1444-14463
α-helix1447-145610
α-helix1460-147920
α-helix1489-150214
α-helix1505-15084
α-helix1519-15257
α-helix1528-154518
α-helix1554-158128
α-helix1592-161524
α-helix1619-16268
α-helix1627-16304
α-helix1634-16396
α-helix1642-165312
α-helix1655-167622
α-helix1697-170711
α-helix1713-17175
β-strand1733110
β-strand1739110
α-helix1745-177733

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Sodium channel protein type 5 subunit alphaAprotein2016Homo sapiensQ14524 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9P24_1 Sodium channel protein type 5 subunit alpha (chains A)
MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQA
SKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPI
RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARG
FCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIV
GALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLV
WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW
AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQN
QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRK
RMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSE
ADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGV
VSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQ
RALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTD
LTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQG
WNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG
NLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWI
ETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQ
LALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVP
PTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQ
PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGS
TADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYH
IVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA
YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM
RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN
KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW
EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK
LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL
AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT
LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA
YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRG
DCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEK
FDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKR
VLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRS
LKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSV
TRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O68
9Z9(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-enC34 H56 O51

Water and common crystallization additives (NA) are not listed.

Primary citation

Structural and functional mechanisms underlying activation gate dynamics and IFM motif accessibility in human Na v 1.5. Biswas, R., Lopez-Serrano, A.L., Purohit, A. et al. Nat Commun (2026) 17. DOI 10.1038/s41467-026-69672-x · PubMed

Other PDB entries of the same protein (UniProt Q14524 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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