voltage-gated sodium channel Nav1.5 with quinidine. Determined by electron microscopy at 3.3 Å resolution. Released 24 Mar 2021.
Explore 6LQA in 3D Show helices and sheets RCSB PDB PDBe
6LQA contains 63 α-helices and 12 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 121-128 | 8 | |
| α-helix | 131-148 | 18 | |
| α-helix | 157-178 | 22 | |
| α-helix | 193-207 | 15 | |
| α-helix | 218-223 | 6 | |
| α-helix | 224-227 | 4 | |
| α-helix | 228-231 | 4 | |
| α-helix | 236-250 | 15 | |
| α-helix | 253-272 | 20 | |
| β-strand | 279-282 | 4 | 1 |
| α-helix | 283 | 1 | |
| β-strand | 294-296 | 3 | 2 |
| β-strand | 300-302 | 3 | 2 |
| α-helix | 304-307 | 4 | |
| β-strand | 316 | 1 | 3 |
| α-helix | 317 | 1 | |
| β-strand | 323 | 1 | 3 |
| β-strand | 325 | 1 | 1 |
| β-strand | 339-342 | 4 | 1 |
| α-helix | 358-369 | 12 | |
| α-helix | 374-385 | 12 | |
| α-helix | 387-389 | 3 | |
| α-helix | 390-396 | 7 | |
| α-helix | 397-405 | 9 | |
| α-helix | 406-428 | 23 | |
| α-helix | 700-714 | 15 | |
| α-helix | 721-734 | 14 | |
| α-helix | 745-770 | 26 | |
| α-helix | 773-776 | 4 | |
| α-helix | 783-797 | 15 | |
| α-helix | 806-812 | 7 | |
| α-helix | 813-819 | 7 | |
| α-helix | 825-835 | 11 | |
| α-helix | 842-861 | 20 | |
| α-helix | 865-868 | 4 | |
| α-helix | 884-896 | 13 | |
| α-helix | 900-910 | 11 | |
| α-helix | 912-942 | 31 | |
| α-helix | 1191-1203 | 13 | |
| α-helix | 1205-1220 | 16 | |
| α-helix | 1221-1224 | 4 | |
| α-helix | 1233-1267 | 35 | |
| α-helix | 1272-1290 | 19 | |
| α-helix | 1299-1303 | 5 | |
| α-helix | 1304-1315 | 12 | |
| α-helix | 1318-1329 | 12 | |
| α-helix | 1332-1356 | 25 | |
| β-strand | 1361-1364 | 4 | 4 |
| β-strand | 1372 | 1 | 4 |
| α-helix | 1373-1374 | 2 | |
| β-strand | 1380 | 1 | 5 |
| α-helix | 1381-1386 | 6 | |
| β-strand | 1394-1397 | 4 | 4 |
| α-helix | 1405-1416 | 12 | |
| α-helix | 1422-1429 | 8 | |
| β-strand | 1436 | 1 | 5 |
| α-helix | 1444-1446 | 3 | |
| α-helix | 1447-1453 | 7 | |
| α-helix | 1454-1460 | 7 | |
| α-helix | 1461-1477 | 17 | |
| α-helix | 1489-1498 | 10 | |
| α-helix | 1518-1520 | 3 | |
| α-helix | 1521-1525 | 5 | |
| α-helix | 1528-1546 | 19 | |
| α-helix | 1554-1581 | 28 | |
| α-helix | 1592-1608 | 17 | |
| α-helix | 1609-1614 | 6 | |
| α-helix | 1621-1626 | 6 | |
| α-helix | 1627-1635 | 9 | |
| α-helix | 1641-1651 | 11 | |
| α-helix | 1654-1678 | 25 | |
| α-helix | 1682-1684 | 3 | |
| α-helix | 1697-1708 | 12 | |
| α-helix | 1714-1720 | 7 | |
| α-helix | 1745-1780 | 36 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Sodium channel protein type 5 subunit alpha | B | protein | 2059 | Homo sapiens | Q14524 (AlphaFold model) |
>6LQA_1 Sodium channel protein type 5 subunit alpha (chains B) MASWSHPQFEKGGGARGGSGGGSWSHPQFEKGFDYKDDDDKGTMANFLLPRGTSSFRRFT RESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQELIG EPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLI MCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLD FSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLT VFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLK NGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERL YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEA MEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTEECGEDRLPKS DSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESH HTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSH LLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELE ESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALE HYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELG LSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVG MQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLL VFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTT WDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQG TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQ VSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDL GQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILL SSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFL IVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNV LLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTK VKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFG SFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKY QGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIV KLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLI RGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTF ANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYII ISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDF ADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEE KFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLS EEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSH SEDLADFPPSPDRDRESIV
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 9 |
| QDN | Quinidine | C20 H24 N2 O2 | 1 |
Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na v 1.5 by the Antiarrhythmic Drug Quinidine*. Li, Z., Jin, X., Wu, T. et al. Angew Chem Int Ed Engl (2021) 60:11474-11480. DOI 10.1002/anie.202102196 · PubMed
Other PDB entries of the same protein (UniProt Q14524 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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