4ECC: PDB entry 4ECC

Chimeric GST Containing Inserts of Kininogen Peptides. Determined by X-ray diffraction at 2.2 Å resolution. Released 16 May 2012.

Method: X-ray diffraction
Resolution: 2.2 Å
Organisms: Schistosoma japonicum, homo sapiens
Chains: 1
Atoms: 1,753
Mol. weight: 26.95 kDa
Released: 16 May 2012

Explore 4ECC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4ECC contains 8 α-helices and 6 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	4-8	5	1
α-helix	12-14	3
α-helix	15-23	9
β-strand	29-33	5	1
β-strand	70-73	4	1
β-strand	76-79	4	1
α-helix	81-91	11
α-helix	99-123	25
α-helix	128-149	22
β-strand	155	1	2
β-strand	158	1	2
α-helix	163-178	16
α-helix	187-198	12
α-helix	200-207	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
chimeric protein between GSHKT10 and domain 5 of kininogen-1	A	protein	231	Schistosoma japonicum, homo sapiens	P01042 (AlphaFold model), P08515 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4ECC_1 chimeric protein between GSHKT10 and domain 5 of kininogen-1 (chains A)
MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGKHGHGHGKHKN
KGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVS
RIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDP
MCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPK

Primary citation

Chimeric glutathione S-transferases containing inserts of kininogen peptides: potential novel protein therapeutics. Bentley, A.A., Merkulov, S.M., Peng, Y. et al. J Biol Chem (2012) 287:22142-22150. DOI 10.1074/jbc.M112.372854 · PubMed

Other PDB entries of the same protein (UniProt P01042 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2WOK 1.7 Å, Clavulanic acid biosynthesis oligopeptide binding protein 2 complexed with bradykinin
4ASR 1.9 Å, Crystal structure of ANCE in complex with Thr6-Bradykinin
4ASQ 1.99 Å, Crystal structure of ANCE in complex with Bradykinin
4ECB 2.2 Å, Chimeric GST Containing Inserts of Kininogen Peptides
1NY2 2.3 Å, Human alpha thrombin inhibited by RPPGF and hirugen
7QOX 2.32 Å, Factor XI and Plasma Kallikrein apple domain structures reveals different kininogen…
7F6I 2.8 Å, Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and kallidin
5I25 2.85 Å, human recombinant coagulation FXI in complex with a peptide derived from human high…
8VJX 2.89 Å, Structure of Human Neurolysin in complex with bradykinin peptide
7F2O 2.9 Å, Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and…
7F6H 2.9 Å, Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and bradykinin
7EIB 3.0 Å, Cryo-EM structure of the type 1 bradykinin receptor in complex with the…

Browse structure collections

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