4G3O: CUE domain of the E3 ubiquitin ligase AMFR

Name: PDB 4G3O: Crystal structure of the CUE domain of the E3 ubiquitin ligase AMFR (gp78)
Published: 2012-07-25
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: ligase

Crystal structure of the CUE domain of the E3 ubiquitin ligase AMFR (gp78). Determined by X-ray diffraction at 1.6 Å resolution. Released 25 Jul 2012.

Method: X-ray diffraction
Resolution: 1.6 Å
Organism: Homo sapiens
Chains: 1
Atoms: 485
Mol. weight: 6.66 kDa
Released: 25 Jul 2012

Explore 4G3O in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4G3O contains 3 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	447-467	21
α-helix	473-483	11
α-helix	486-494	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
E3 ubiquitin-protein ligase AMFR	A	protein	58	Homo sapiens	Q9UKV5 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4G3O_1 E3 ubiquitin-protein ligase AMFR (chains A)
GSMGYRGSENLYFQGQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRI

Primary citation

Crystal structure of the CUE domain of the E3 ubiquitin ligase AMFR (gp78). Kozlov, G., LePage, K., Gehring, K. To be published.

Other PDB entries of the same protein (UniProt Q9UKV5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3H8K 1.8 Å, Crystal structure of Ube2g2 complxed with the G2BR domain of gp78 at 1.8-A resolution
3TIW 1.8 Å, Crystal structure of p97N in complex with the C-terminus of gp78
8T0S 1.95 Å, Crystal structure of UBE2G2 adduct with phenethyl isothiocyanate (PEITC) at the Cys48…
4LAD 2.3 Å, Crystal Structure of the Ube2g2:RING-G2BR complex
3FSH 2.76 Å, Crystal structure of the ubiquitin conjugating enzyme Ube2g2 bound to the G2BR domain of…
2EJS Solution structure of RUH-076, a human CUE domain
2LVN Structure of the gp78 CUE domain
2LVO Structure of the gp78CUE domain bound to monubiquitin
2LVP gp78CUE domain bound to the distal ubiquitin of K48-linked diubiquitin
2LVQ gp78CUE domain bound to the proximal ubiquitin of K48-linked diubiquitin
2LXH NMR structure of the RING domain in ubiquitin ligase gp78
2LXP NMR structure of two domains in ubiquitin ligase gp78, RING and G2BR, bound to its…

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