4GU5: Full-length Drosophila Cryptochrome

Structure of Full-length Drosophila Cryptochrome. Determined by X-ray diffraction at 2.3 Å resolution. Released 26 Sept 2012.

Method
X-ray diffraction
Resolution
2.3 Å
Organism
Drosophila melanogaster
Chains
2
Atoms
9,186
Mol. weight
126.2 kDa
Ligands
MG, FAD
Released
26 Sept 2012

Explore 4GU5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4GU5 contains 72 α-helices and 21 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 35 helices, 10 β-strands

ElementResiduesLengthSheet
β-strand6-1161
α-helix21-277
α-helix30-323
β-strand35-4281
α-helix54-7421
β-strand82-8541
α-helix88-9811
β-strand101-10771
α-helix112-1143
α-helix115-12814
β-strand131-13551
α-helix143-1497
α-helix158-16811
α-helix171-1755
α-helix187-1893
α-helix190-1956
β-strand19811
α-helix205-2084
α-helix227-24721
α-helix267-2726
α-helix277-28812
β-strand296-29722
β-strand300-30122
α-helix303-3053
α-helix306-32217
α-helix342-3443
α-helix347-3548
α-helix361-37313
α-helix378-38811
α-helix397-40711
α-helix413-42513
α-helix430-4334
α-helix435-4384
α-helix440-4478
α-helix452-4576
α-helix459-4613
α-helix466-4694
α-helix472-4743
α-helix477-4826
β-strand48713
β-strand49113
α-helix492-4943
α-helix498-51619
α-helix519-5202
α-helix528-5358
Chain B: 37 helices, 11 β-strands
ElementResiduesLengthSheet
β-strand6-1164
α-helix21-277
α-helix30-323
β-strand35-4284
α-helix54-7522
β-strand82-8544
α-helix88-9811
β-strand101-10774
α-helix112-1143
α-helix115-12814
β-strand131-13554
α-helix143-1497
α-helix158-16811
α-helix171-1788
β-strand18514
α-helix186-1894
α-helix190-1956
β-strand19814
α-helix202-2043
α-helix205-2084
α-helix227-24721
α-helix252-2554
α-helix267-2726
α-helix277-28812
β-strand296-29725
β-strand300-30125
α-helix303-3053
α-helix306-32217
α-helix342-3454
α-helix347-3559
α-helix361-37313
α-helix378-38811
α-helix398-40710
α-helix413-42412
α-helix430-4334
α-helix435-4384
α-helix440-4478
α-helix452-4576
α-helix459-4613
α-helix466-4694
α-helix472-4743
α-helix477-4826
β-strand48716
β-strand49116
α-helix492-4943
α-helix498-51619
α-helix519-5202
α-helix528-5347

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Cryptochrome-1A, Bprotein539Drosophila melanogasterO77059 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>4GU5_1 Cryptochrome-1 (chains A, B)
MATRGANVIWFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNVGYNRMRFL
LDSLQDIDDQLQAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDES
IRSLCRELNIDFVEKVSHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARL
EDATFVELDPEFCRSLKLFEQLPTPEHFNVYGDNMGFLAKINWRGGETQALLLLDERLKV
EQHAFERGFYLPNQALPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGV
QMTGGAHITGQLIWREYFYTMSVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGF
PLIDGAMRQLLAEGWLHHTLRNTVATFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNW
MWVSSSAFERLLDSSLVTCPVALAKRLDPDGTYIKQYVPELMNVPKEFVHEPWRMSAEQQ
EQYECLIGVHYPERIIDLSMAVKRNMLAMKSLRNSLITPPPHCRPSNEEEVRQFFWLAD

Ligands and cofactors

IDNameFormulaCopies
MGMagnesium ionMg2
FADFlavin-adenine dinucleotideC27 H33 N9 O15 P22

Primary citation

Updated structure of Drosophila cryptochrome. Levy, C., Zoltowski, B.D., Jones, A.R. et al. Nature (2013) 495:E3-E4. DOI 10.1038/nature11995 · PubMed

Other PDB entries of the same protein (UniProt O77059 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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