7UD0: Room Temperature Drosophila Cryptochrome

Room Temperature Drosophila Cryptochrome. Determined by X-ray diffraction at 3.5 Å resolution. Released 24 Aug 2022.

Method
X-ray diffraction
Resolution
3.5 Å
Organism
Drosophila melanogaster
Chains
2
Atoms
8,853
Mol. weight
126.15 kDa
Ligands
FAD
Released
24 Aug 2022

Explore 7UD0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7UD0 contains 71 α-helices and 24 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 36 helices, 12 β-strands

ElementResiduesLengthSheet
β-strand6-1161
α-helix21-266
α-helix30-323
β-strand35-4281
α-helix54-7522
β-strand82-8541
α-helix88-9811
β-strand101-10771
α-helix112-1143
α-helix115-12713
β-strand131-13551
α-helix143-1497
α-helix158-16811
α-helix171-1788
β-strand18511
α-helix190-1956
α-helix202-2043
α-helix205-2084
α-helix227-24721
α-helix267-2715
α-helix277-28711
β-strand296-29722
β-strand300-30122
α-helix303-3053
α-helix306-32116
α-helix3421
β-strand34313
α-helix344-3452
α-helix347-3548
α-helix361-37212
α-helix378-38811
β-strand39513
α-helix397-40711
α-helix413-42412
α-helix430-4334
α-helix435-4384
α-helix440-4478
α-helix452-4576
α-helix459-4613
α-helix466-4694
α-helix472-4743
α-helix477-4826
β-strand48714
β-strand49114
α-helix492-4943
α-helix498-51619
α-helix519-5202
α-helix528-5347
Chain B: 35 helices, 12 β-strands
ElementResiduesLengthSheet
β-strand6-1165
α-helix21-266
α-helix30-323
β-strand35-4285
α-helix54-7522
β-strand82-8545
α-helix88-9811
β-strand101-10775
α-helix112-1143
α-helix115-12713
β-strand131-13555
α-helix143-1497
α-helix158-16811
α-helix171-1788
β-strand18515
α-helix190-1956
α-helix202-2043
α-helix205-2084
α-helix227-24721
α-helix267-2726
α-helix277-28711
β-strand296-29726
β-strand300-30126
α-helix303-3053
α-helix306-32116
α-helix3421
β-strand34317
α-helix344-3452
α-helix347-3548
α-helix361-37212
α-helix378-38811
β-strand39517
α-helix397-40711
α-helix413-42412
α-helix430-4334
α-helix435-4384
α-helix440-4478
α-helix452-4576
α-helix459-4613
α-helix466-4694
α-helix472-4743
α-helix477-4826
β-strand48718
β-strand49118
α-helix498-51619
α-helix519-5202
α-helix528-5347

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Cryptochrome-1A, Bprotein539Drosophila melanogasterO77059 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>7UD0_1 Cryptochrome-1 (chains A, B)
MATRGANVIWFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNVGYNRMRFL
LDSLQDIDDQLQAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDES
IRSLCRELNIDFVEKVSHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARL
EDATFVELDPEFCRSLKLFEQLPTPEHFNVYGDNMGFLAKINWRGGETQALLLLDERLKV
EQHAFERGFYLPNQALPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGV
QMTGGAHITGQLIWREYFYTMSVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGF
PLIDGAMRQLLAEGWLHHTLRNTVATFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNW
MWVSSSAFERLLDSSLVTCPVALAKRLDPDGTYIKQYVPELMNVPKEFVHEPWRMSAEQQ
EQYECLIGVHYPERIIDLSMAVKRNMLAMKSLRNSLITPPPHCRPSNEEEVRQFFWLAD

Ligands and cofactors

IDNameFormulaCopies
FADFlavin-adenine dinucleotideC27 H33 N9 O15 P22

Primary citation

Room-temperature serial synchrotron crystallography of Drosophila cryptochrome. Schneps, C.M., Ganguly, A., Crane, B.R. Acta Crystallogr D Struct Biol (2022) 78:975-985. DOI 10.1107/S2059798322007008 · PubMed

Other PDB entries of the same protein (UniProt O77059 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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