4JZY: Drosophila Cryptochrome

Crystal structures of Drosophila Cryptochrome. Determined by X-ray diffraction at 2.34 Å resolution. Released 26 Jun 2013.

Method
X-ray diffraction
Resolution
2.34 Å
Organism
Drosophila melanogaster
Chains
2
Atoms
9,345
Mol. weight
125.37 kDa
Ligands
FAD
Released
26 Jun 2013

Explore 4JZY in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4JZY contains 72 α-helices and 21 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 33 helices, 11 β-strands

ElementResiduesLengthSheet
β-strand6-1161
α-helix21-277
α-helix30-323
β-strand35-4281
α-helix54-7320
β-strand82-8541
α-helix88-9811
β-strand101-10771
α-helix112-1143
α-helix115-12814
β-strand131-13551
α-helix143-1497
α-helix158-16811
α-helix171-1788
β-strand18511
α-helix187-1893
α-helix190-1956
β-strand19811
α-helix205-2084
β-strand213-21422
β-strand217-21822
α-helix2191
α-helix227-24620
α-helix267-2726
α-helix277-28812
α-helix306-32217
α-helix342-3454
α-helix347-3559
α-helix361-37313
α-helix378-38811
α-helix397-40711
α-helix413-42412
α-helix430-4323
α-helix440-4478
α-helix452-4576
α-helix459-4613
α-helix466-4694
α-helix472-4743
α-helix477-4826
β-strand48713
β-strand49113
α-helix492-4943
α-helix498-51518
α-helix528-5347
Chain B: 39 helices, 10 β-strands
ElementResiduesLengthSheet
α-helix1-44
β-strand6-1164
α-helix21-277
α-helix30-323
β-strand35-4284
α-helix54-7421
β-strand82-8544
α-helix88-9811
β-strand101-10774
α-helix112-1143
α-helix115-12814
β-strand131-13554
α-helix143-1497
α-helix158-16811
α-helix171-1744
α-helix176-1783
α-helix186-1894
α-helix190-1956
β-strand19814
α-helix202-2043
α-helix205-2084
β-strand213-21425
β-strand217-21825
α-helix2191
α-helix227-24620
α-helix252-2543
α-helix267-2726
α-helix277-28610
α-helix306-32217
α-helix342-3454
α-helix347-3559
α-helix361-37313
α-helix378-38811
α-helix397-40711
α-helix413-42412
α-helix430-4334
α-helix435-4384
α-helix440-4478
α-helix452-4576
α-helix459-4613
α-helix466-4694
α-helix472-4743
α-helix477-4826
β-strand48716
β-strand49116
α-helix492-4943
α-helix498-51619
α-helix519-5202
α-helix528-5347

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Cryptochrome-1A, Bprotein536Drosophila melanogasterO77059 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>4JZY_1 Cryptochrome-1 (chains A, B)
AMATRGANVIWFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNVGYNRMRF
LLDSLQDIDDQLQAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDE
SIRSLCRELNIDFVEKVSHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADAR
LEDATFVELDPEFCRSLKLFEQLPTPEHFNVYGDNMGFLAKINWRGGETQALLLLDERLK
VEQHAFERGFYLPNQALPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLGVQMTG
GAHITGQLIWREYFYTMSVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLID
GAMRQLLAEGWLHHTLRNTVATFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVS
SSAFERLLDSSLVTCPVALAKRLDPDGTYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYE
CLIGVHYPERIIDLSMAVKRNMLAMKSLRNSLITPPPHCRPSNEEEVRQFFWLADV

Ligands and cofactors

IDNameFormulaCopies
FADFlavin-adenine dinucleotideC27 H33 N9 O15 P22

Water and common crystallization additives (NA, NH4) are not listed.

Primary citation

Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function. Czarna, A., Berndt, A., Singh, H.R. et al. Cell (2013) 153:1394-1405. DOI 10.1016/j.cell.2013.05.011 · PubMed

Other PDB entries of the same protein (UniProt O77059 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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