Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 1). Determined by X-ray diffraction at 2.5 Å resolution. Released 26 Mar 2014.
Explore 4L0Y in 3D Show helices and sheets RCSB PDB PDBe
4L0Y contains 8 α-helices and 17 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 51-57 | 7 | |
| β-strand | 62-64 | 3 | 1 |
| β-strand | 70-73 | 4 | 1 |
| β-strand | 78-80 | 3 | 2 |
| α-helix | 83-85 | 3 | |
| β-strand | 90-93 | 4 | 1 |
| β-strand | 102-108 | 7 | 3 |
| β-strand | 117-118 | 2 | 4 |
| β-strand | 121-123 | 3 | 3 |
| β-strand | 124-125 | 2 | 1 |
| β-strand | 128-130 | 3 | 1 |
| β-strand | 135-136 | 2 | 4 |
| β-strand | 146-152 | 7 | 3 |
| β-strand | 158-166 | 9 | 3 |
| β-strand | 167-169 | 3 | 2 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 337-345 | 9 | |
| α-helix | 348-350 | 3 | |
| β-strand | 355-356 | 2 | 5 |
| β-strand | 362-364 | 3 | 5 |
| α-helix | 368-379 | 12 | |
| α-helix | 386-394 | 9 | |
| β-strand | 402-404 | 3 | 5 |
| β-strand | 411-414 | 4 | 5 |
| α-helix | 418-422 | 5 | |
| α-helix | 426-432 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Runt-related transcription factor 1 | A | protein | 242 | Mus musculus | Q03347 (AlphaFold model) |
| Protein C-ets-1 | B | protein | 146 | Homo sapiens | P14921 (AlphaFold model) |
| 5'-d(*gp*gp*ap*ap*gp*cp*cp*ap*cp*ap*tp*cp*cp*tp*cp*t)-3' | C | DNA | 16 | Homo sapiens | |
| 5'-d(*cp*ap*gp*ap*gp*gp*ap*tp*gp*tp*gp*gp*cp*tp*tp*c)-3' | D | DNA | 16 | Homo sapiens |
>4L0Y_1 Runt-related transcription factor 1 (chains A) MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPG ELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNA TAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHR QKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQM QD
>4L0Y_2 Protein C-ets-1 (chains B) PNHKPKGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFIS WTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFV CDLQSLLGYTPEELHAMLDVKPDADE
>4L0Y_3 5'-D(*GP*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3' (chains C) GGAAGCCACATCCTCT
>4L0Y_4 5'-D(*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3' (chains D) CAGAGGATGTGGCTTC
Structural basis of Ets1 activation by Runx1. Shrivastava, T., Mino, K., Babayeva, N.D. et al. Leukemia (2014) 28:2040-2048. DOI 10.1038/leu.2014.111 · PubMed
Other PDB entries of the same protein (UniProt Q03347 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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