4LZX: Complex of IQCG and Ca2+-free CaM

Complex of IQCG and Ca2+-free CaM. Determined by X-ray diffraction at 1.5 Å resolution. Released 7 May 2014.

Method: X-ray diffraction
Resolution: 1.5 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,877
Mol. weight: 21.41 kDa
Released: 7 May 2014

Explore 4LZX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4LZX contains 12 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	7-19	13
β-strand	27-29	3	1
α-helix	30-39	10
α-helix	46-56	11
α-helix	57-59	3
β-strand	63-65	3	1
α-helix	66-74	9
α-helix	82-91	10
β-strand	100-102	3	2
α-helix	103-112	10
α-helix	116-118	3
α-helix	119-129	11
β-strand	136-138	3	2
α-helix	139-147	9

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	385-387	3
α-helix	388-410	23

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A	protein	148	Homo sapiens	P0DP23 (AlphaFold model)
IQ domain-containing protein G	B	protein	40	Homo sapiens	Q9H095 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4LZX_1 Calmodulin (chains A)
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B), FASTA

>4LZX_2 IQ domain-containing protein G (chains B)
GPLGSQDLLELKSVIKLQAWWRGTMIRREIGGFKMPKDKV

Primary citation

Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish. Chen, L.T., Liang, W.X., Chen, S. et al. Nat Commun (2014) 5:3811-3811. DOI 10.1038/ncomms4811 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93
6DAD 1.65 Å, 1.65 Angstrom crystal structure of the N97I Ca/CaM:CaV1.2 IQ domain complex

Browse structure collections

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