7BF1: Ca2+-Calmodulin

Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2 binding mode. Determined by X-ray diffraction at 1.24 Å resolution. Released 21 Jul 2021.

Method: X-ray diffraction
Resolution: 1.24 Å
Organism: Homo sapiens
Chains: 3
Atoms: 1,639
Mol. weight: 21.46 kDa
Ligands: ACE, CA
Released: 21 Jul 2021

Explore 7BF1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7BF1 contains 9 α-helices and 6 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain AAA: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	7-20	14
β-strand	27-28	2	1
α-helix	30-39	10
α-helix	46-56	11
β-strand	64-65	2	1
α-helix	66-93	28
β-strand	100-101	2	2
α-helix	103-113	11
α-helix	119-129	11
β-strand	137-138	2	2
α-helix	139-147	9

Chain CCC: 1 helix, 2 β-strands

Element	Residues	Length	Sheet
β-strand	302	1	3
β-strand	305	1	3
α-helix	308-317	10

Chain DDD: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	308-315	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin-1	AAA	protein	149	Homo sapiens	P0DP23 (AlphaFold model)
Creatine kinase B-type	CCC, DDD	protein	18	Homo sapiens	P12277 (AlphaFold model)

Sequence of entity 1 (AAA), FASTA

>7BF1_1 Calmodulin-1 (chains AAA)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (CCC, DDD), FASTA

>7BF1_2 Creatine kinase B-type (chains CCC, DDD)
NLGKHEKFSEVLKRLRLQ

Ligands and cofactors

ID	Name	Formula	Copies
ACE	Acetyl group	C2 H4 O	1
CA	Calcium ion	Ca	4

Primary citation

Calmodulin complexes with brain and muscle creatine kinase peptides. Sprenger, J., Trifan, A., Patel, N. et al. Curr Res Struct Biol (2021) 3:121-132. DOI 10.1016/j.crstbi.2021.05.001 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93
6DAD 1.65 Å, 1.65 Angstrom crystal structure of the N97I Ca/CaM:CaV1.2 IQ domain complex

Browse structure collections

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