2W73: Calmodulin

High-resolution structure of the complex between calmodulin and a peptide from calcineurin A. Determined by X-ray diffraction at 1.45 Å resolution. Released 12 May 2009.

Method: X-ray diffraction
Resolution: 1.45 Å
Organism: HOMO SAPIENS
Chains: 8
Atoms: 6,079
Mol. weight: 76.07 kDa
Ligands: CA
Released: 12 May 2009

Explore 2W73 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2W73 contains 32 α-helices and 16 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	27	1	1
α-helix	29-38	10
α-helix	45-53	9
β-strand	63	1	1
α-helix	65-92	28
β-strand	100	1	2
α-helix	102-111	10
α-helix	118-128	11
β-strand	136	1	2
α-helix	138-146	9

Chain B: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	27	1	3
α-helix	29-38	10
α-helix	45-53	9
β-strand	63	1	3
α-helix	65-92	28
β-strand	99-100	2	4
α-helix	102-111	10
α-helix	118-128	11
β-strand	136-137	2	4
α-helix	138-145	8

Chain E: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	27	1	5
α-helix	29-38	10
α-helix	45-55	11
β-strand	63	1	5
α-helix	65-92	28
β-strand	99-100	2	6
α-helix	102-111	10
α-helix	122-128	7
β-strand	136-137	2	6
α-helix	138-146	9

Chain F: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-27	2	7
α-helix	29-38	10
α-helix	45-53	9
β-strand	63-64	2	7
α-helix	65-92	28
β-strand	99-100	2	8
α-helix	102-111	10
α-helix	118-128	11
β-strand	136-137	2	8
α-helix	138-146	9

Chain K: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	396-409	14

Chains L, M and O: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	396-410	15

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A, B, E, F	protein	149	HOMO SAPIENS	P0DP23 (AlphaFold model)
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	K, L, M, O	protein	17	HOMO SAPIENS	Q08209 (AlphaFold model)

Sequence of entity 1 (A, B, E, F), FASTA

>2W73_1 CALMODULIN (chains A, B, E, F)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (K, L, M, O), FASTA

>2W73_2 SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (chains K, L, M, O)
VIRNKIRAIGKMARVFS

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	20

Primary citation

Domain Swapping and Different Oligomeric States for the Complex between Calmodulin and the Calmodulin-Binding Domain of Calcineurin A. Majava, V., Kursula, P. PLoS One (2009) 4:E5402. DOI 10.1371/JOURNAL.PONE.0005402 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93
6DAD 1.65 Å, 1.65 Angstrom crystal structure of the N97I Ca/CaM:CaV1.2 IQ domain complex

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