4OWW: SOSS1

Structural basis of SOSS1 in complex with a 35nt ssDNA. Determined by X-ray diffraction at 2.3 Å resolution. Released 16 Apr 2014.

Method
X-ray diffraction
Resolution
2.3 Å
Organism
Homo sapiens
Chains
4
Atoms
5,184
Mol. weight
100.47 kDa
Released
16 Apr 2014

Explore 4OWW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4OWW contains 38 α-helices and 14 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 35 helices, 5 β-strands

ElementResiduesLengthSheet
β-strand3711
β-strand4312
α-helix44-463
α-helix47-6115
α-helix68-7912
α-helix83-9917
α-helix101-11414
α-helix120-13314
α-helix134-1363
β-strand13711
α-helix139-15416
α-helix160-16910
α-helix178-19316
α-helix195-1984
α-helix202-21615
α-helix223-24220
α-helix244-2474
α-helix248-2503
α-helix253-2597
α-helix265-27612
α-helix278-2803
α-helix288-2925
α-helix295-2973
α-helix298-3025
α-helix307-31610
β-strand32113
α-helix326-33611
α-helix340-3445
α-helix345-35511
α-helix361-3644
β-strand36813
α-helix371-38010
α-helix385-39612
α-helix409-42214
α-helix427-44317
α-helix446-4483
α-helix449-46517
α-helix473-4764
α-helix483-49210
α-helix494-4963
Chain B: 2 helices, 7 β-strands
ElementResiduesLengthSheet
α-helix7-93
β-strand17-26102
β-strand3012
β-strand38-4582
β-strand48-5582
α-helix56-616
β-strand66-78132
β-strand81-97172
β-strand10712
Chain C: 1 helix, 2 β-strands
ElementResiduesLengthSheet
α-helix64-7815
β-strand83-8534
β-strand94-9634

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
DNA (5'-d(p*tp*tp*tp*tp*tp*t)-3')LDNA35Homo sapiens
Integrator complex subunit 3Aprotein500Homo sapiensQ68E01 (AlphaFold model)
SOSS complex subunit B1Bprotein211Homo sapiensQ9BQ15 (AlphaFold model)
SOSS complex subunit CCprotein104Homo sapiensQ9NRY2 (AlphaFold model)
Sequence of entity 1 (L), FASTA
>4OWW_1 DNA (5'-D(P*TP*TP*TP*TP*TP*T)-3') (chains L)
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
Sequence of entity 2 (A), FASTA
>4OWW_2 Integrator complex subunit 3 (chains A)
MELQKGKGAAAAAAASGAAGGGGGGAGAGAPGGGRLLLSTSLDAKDELEERLERCMSIVT
SMTAGVSEREANDALNAYVCKGLPQHEEICLGLFTLILTEPAQAQKCYRDLALVSRDGMN
IVLNKINQILMEKYLKLQDTCRTQLVWLVRELVKSGVLGADGVCMTFMKQIAGGDVTAKN
IWLAESVLDILTEQREWVLKSSILIAMAVYTYLRLIVDHHGTAQLQALRQKEVDFCISLL
RERFMECLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKF
LACRLTPDMETKLLFMTSRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPS
NEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVMH
HSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPK
LDKELRAMLREKFPEFCSSP
Sequence of entity 3 (B), FASTA
>4OWW_3 SOSS complex subunit B1 (chains B)
MTTETFVKDIKPGLKNLNLIFIVLETGRVTKTKDGHEVRTCKVADKTGSINISVWDDVGN
LIQPGDIIRLTKGYASVFKGCLTLYTGRGGDLQKIGEFCMVYSEVPNFSEPNPEYSTQQA
PNKAVQNDSNPSASQPTTGPSAASPASENQNGNGLSAPPGPGGGPHPPHTPSHPPSTRIT
RSQPNHTPAGPPGPSSNPVSNGKETRRSSKR
Sequence of entity 4 (C), FASTA
>4OWW_4 SOSS complex subunit C (chains C)
MAANSSGQGFQNKNRVAILAELDKEKRKLLMQNQSSTNHPGASIALSRPSLNKDFRDHAE
QQHIAAQQKAALQHAHAHSSGYFITQDSAFGNLILPVLPRLDPE

Primary citation

Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA. Ren, W., Chen, H., Sun, Q. et al. Cell Rep (2014) 6:982-991. DOI 10.1016/j.celrep.2014.02.020 · PubMed

Other PDB entries of the same protein (UniProt Q68E01 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 4OWW directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.