8RBZ: Unk-unk-unk-unk-unk-unk-unk-unk-unk
Structure of Integrator-PP2A-SOSS-CTD post-termination complex. Determined by electron microscopy at 3.7 Å resolution. Released 7 Feb 2024.
- Method
- Electron microscopy
- Resolution
- 3.7 Å
- Organisms
- Sus scrofa, Homo sapiens, Trichoplusia ni
- Chains
- 21
- Atoms
- 74,102
- Mol. weight
- 1588.88 kDa
- Ligands
- ZN, MN
- Released
- 7 Feb 2024
Explore 8RBZ in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8RBZ contains 613 α-helices and 172 β-strands across 20 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 73 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 947-959 | 13 | |
| α-helix | 965-976 | 12 | |
| α-helix | 984-998 | 15 | |
| α-helix | 1024-1026 | 3 | |
| α-helix | 1027 | 1 | |
| α-helix | 1028-1032 | 5 | |
| α-helix | 1039-1056 | 18 | |
| α-helix | 1060-1072 | 13 | |
| α-helix | 1079-1095 | 17 | |
| α-helix | 1098-1103 | 6 | |
| α-helix | 1111-1132 | 22 | |
| α-helix | 1134-1135 | 2 | |
| β-strand | 1149-1153 | 5 | 6 |
| β-strand | 1159-1163 | 5 | 6 |
| α-helix | 1164-1175 | 12 | |
| α-helix | 1184-1193 | 10 | |
| α-helix | 1199-1201 | 3 | |
| β-strand | 1202-1205 | 4 | 6 |
| β-strand | 1211 | 1 | 6 |
| α-helix | 1217-1225 | 9 | |
| α-helix | 1229-1236 | 8 | |
| α-helix | 1241-1249 | 9 | |
| α-helix | 1255-1271 | 17 | |
| α-helix | 1273-1279 | 7 | |
| α-helix | 1283-1296 | 14 | |
| α-helix | 1302-1310 | 9 | |
| α-helix | 1362-1368 | 7 | |
| α-helix | 1374-1392 | 19 | |
| α-helix | 1402-1414 | 13 | |
| α-helix | 1421-1427 | 7 | |
| α-helix | 1429-1445 | 17 | |
| α-helix | 1452-1467 | 16 | |
| α-helix | 1470-1472 | 3 | |
| α-helix | 1476-1490 | 15 | |
| α-helix | 1497-1510 | 14 | |
| α-helix | 1514-1530 | 17 | |
| α-helix | 1538-1551 | 14 | |
| α-helix | 1556-1564 | 9 | |
| α-helix | 1579-1588 | 10 | |
| α-helix | 1612-1614 | 3 | |
| α-helix | 1615-1625 | 11 | |
| α-helix | 1634-1641 | 8 | |
| α-helix | 1657-1667 | 11 | |
| α-helix | 1670-1682 | 13 | |
| α-helix | 1691-1702 | 12 | |
| α-helix | 1729-1747 | 19 | |
| α-helix | 1756-1769 | 14 | |
| α-helix | 1773-1790 | 18 | |
| α-helix | 1794-1809 | 16 | |
| α-helix | 1819-1822 | 4 | |
| α-helix | 1826-1828 | 3 | |
| α-helix | 1836-1847 | 12 | |
| α-helix | 1853-1872 | 20 | |
| α-helix | 1874-1878 | 5 | |
| α-helix | 1881-1891 | 11 | |
| α-helix | 1896-1901 | 6 | |
| α-helix | 1904-1917 | 14 | |
| α-helix | 1919-1922 | 4 | |
| α-helix | 1928-1944 | 17 | |
| α-helix | 1950-1952 | 3 | |
| α-helix | 1953-1969 | 17 | |
| α-helix | 1971-1980 | 10 | |
| α-helix | 1982-1991 | 10 | |
| α-helix | 1996-2004 | 9 | |
| α-helix | 2043-2046 | 4 | |
| α-helix | 2048-2056 | 9 | |
| α-helix | 2060-2074 | 15 | |
| α-helix | 2078-2082 | 5 | |
| α-helix | 2085-2089 | 5 | |
| α-helix | 2090-2093 | 4 | |
| α-helix | 2097-2113 | 17 | |
| α-helix | 2115-2121 | 7 | |
| α-helix | 2122-2130 | 9 | |
| α-helix | 2134-2142 | 9 | |
| α-helix | 2144-2151 | 8 | |
| α-helix | 2155-2168 | 14 | |
| α-helix | 2174-2188 | 15 | |
Chain b: 77 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 20-28 | 9 | |
| α-helix | 31-36 | 6 | |
| α-helix | 39-44 | 6 | |
| α-helix | 46-52 | 7 | |
| α-helix | 62-75 | 14 | |
| α-helix | 80-89 | 10 | |
| α-helix | 92-106 | 15 | |
| α-helix | 126-132 | 7 | |
| α-helix | 135-155 | 21 | |
| α-helix | 176-187 | 12 | |
| α-helix | 194-202 | 9 | |
| α-helix | 207-217 | 11 | |
| α-helix | 219-221 | 3 | |
| α-helix | 222-230 | 9 | |
| α-helix | 241-256 | 16 | |
| α-helix | 258-260 | 3 | |
| α-helix | 261-271 | 11 | |
| α-helix | 275-286 | 12 | |
| α-helix | 297-307 | 11 | |
| α-helix | 311-326 | 16 | |
| α-helix | 335-350 | 16 | |
| α-helix | 381-394 | 14 | |
| α-helix | 395-399 | 5 | |
| α-helix | 402-404 | 3 | |
| α-helix | 405-415 | 11 | |
| α-helix | 423-438 | 16 | |
| α-helix | 440-443 | 4 | |
| α-helix | 446-461 | 16 | |
| α-helix | 464-466 | 3 | |
| α-helix | 476-489 | 14 | |
| α-helix | 492-503 | 12 | |
| α-helix | 511-520 | 10 | |
| α-helix | 521-525 | 5 | |
| α-helix | 528-537 | 10 | |
| α-helix | 539-540 | 2 | |
| β-strand | 544 | 1 | 7 |
| α-helix | 553-562 | 10 | |
| α-helix | 565-569 | 5 | |
| α-helix | 574-582 | 9 | |
| β-strand | 584 | 1 | 7 |
| α-helix | 588-589 | 2 | |
| α-helix | 592-602 | 11 | |
| α-helix | 610-614 | 5 | |
| α-helix | 617-622 | 6 | |
| α-helix | 645-666 | 22 | |
| α-helix | 678-680 | 3 | |
| α-helix | 681-686 | 6 | |
| α-helix | 689-698 | 10 | |
| α-helix | 704-717 | 14 | |
| α-helix | 719-722 | 4 | |
| α-helix | 724-730 | 7 | |
| α-helix | 736-744 | 9 | |
| α-helix | 745-747 | 3 | |
| α-helix | 754-761 | 8 | |
| α-helix | 768-778 | 11 | |
| α-helix | 787-789 | 3 | |
| α-helix | 790-795 | 6 | |
| α-helix | 796-801 | 6 | |
| α-helix | 807-823 | 17 | |
| α-helix | 825-835 | 11 | |
| α-helix | 850-855 | 6 | |
| α-helix | 857-861 | 5 | |
| α-helix | 865-869 | 5 | |
| α-helix | 871-898 | 28 | |
| α-helix | 923-946 | 24 | |
| α-helix | 950-953 | 4 | |
| α-helix | 989-1007 | 19 | |
| α-helix | 1009-1018 | 10 | |
| α-helix | 1022-1024 | 3 | |
| α-helix | 1025-1031 | 7 | |
| α-helix | 1033-1037 | 5 | |
| α-helix | 1038-1046 | 9 | |
| α-helix | 1051-1067 | 17 | |
| α-helix | 1071-1087 | 17 | |
| α-helix | 1093-1103 | 11 | |
| α-helix | 1105-1113 | 9 | |
| α-helix | 1115-1117 | 3 | |
| α-helix | 1118-1138 | 21 | |
| α-helix | 1181-1201 | 21 | |
Chain B: 2 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-9 | 3 | |
| β-strand | 21-22 | 2 | 1 |
| β-strand | 28 | 1 | 2 |
| β-strand | 32 | 1 | 3 |
| β-strand | 36 | 1 | 3 |
| β-strand | 39-44 | 6 | 2 |
| β-strand | 49-54 | 6 | 2 |
| α-helix | 56-61 | 6 | |
| β-strand | 66-71 | 6 | 1 |
| β-strand | 74-78 | 5 | 2 |
| β-strand | 81-85 | 5 | 2 |
| β-strand | 91-97 | 7 | 1 |
Chain c: 36 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 47-63 | 17 | |
| α-helix | 68-81 | 14 | |
| α-helix | 83-97 | 15 | |
| α-helix | 101-114 | 14 | |
| α-helix | 120-133 | 14 | |
| α-helix | 134-136 | 3 | |
| α-helix | 139-155 | 17 | |
| α-helix | 160-169 | 10 | |
| α-helix | 171-172 | 2 | |
| α-helix | 178-193 | 16 | |
| α-helix | 195-199 | 5 | |
| α-helix | 202-218 | 17 | |
| α-helix | 223-242 | 20 | |
| α-helix | 244-247 | 4 | |
| α-helix | 248-250 | 3 | |
| α-helix | 253-260 | 8 | |
| α-helix | 265-276 | 12 | |
| α-helix | 278-281 | 4 | |
| α-helix | 288-293 | 6 | |
| α-helix | 298-303 | 6 | |
| α-helix | 307-318 | 12 | |
| α-helix | 320 | 1 | |
| β-strand | 321 | 1 | 8 |
| α-helix | 325-335 | 11 | |
| α-helix | 342-355 | 14 | |
| α-helix | 361-365 | 5 | |
| β-strand | 368 | 1 | 8 |
| α-helix | 371-380 | 10 | |
| α-helix | 385-397 | 13 | |
| α-helix | 398-401 | 4 | |
| α-helix | 409-411 | 3 | |
| α-helix | 413-421 | 9 | |
| α-helix | 427-444 | 18 | |
| α-helix | 446-448 | 3 | |
| α-helix | 449-465 | 17 | |
| α-helix | 473-476 | 4 | |
| α-helix | 483-492 | 10 | |
| α-helix | 494-496 | 3 | |
Chain C: 1 helix, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 63-78 | 16 | |
| β-strand | 85 | 1 | 4 |
| β-strand | 94 | 1 | 4 |
Chain d: 47 helices, 16 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 36-45 | 10 | |
| α-helix | 51-61 | 11 | |
| α-helix | 66-82 | 17 | |
| α-helix | 86-100 | 15 | |
| α-helix | 109-120 | 12 | |
| α-helix | 124-140 | 17 | |
| α-helix | 145-158 | 14 | |
| α-helix | 164-176 | 13 | |
| α-helix | 196-202 | 7 | |
| α-helix | 203-205 | 3 | |
| α-helix | 209-225 | 17 | |
| α-helix | 227-229 | 3 | |
| α-helix | 232-240 | 9 | |
| α-helix | 246-251 | 6 | |
| α-helix | 255-262 | 8 | |
| β-strand | 267-269 | 3 | 9 |
| β-strand | 276-278 | 3 | 9 |
| α-helix | 279-291 | 13 | |
| α-helix | 296-307 | 12 | |
| α-helix | 314-321 | 8 | |
| α-helix | 378-383 | 6 | |
| α-helix | 388-404 | 17 | |
| α-helix | 406-419 | 14 | |
| α-helix | 425-437 | 13 | |
| α-helix | 446-456 | 11 | |
| α-helix | 461-473 | 13 | |
| α-helix | 479-495 | 17 | |
| α-helix | 497-499 | 3 | |
| α-helix | 500-513 | 14 | |
| α-helix | 515-518 | 4 | |
| α-helix | 519-521 | 3 | |
| α-helix | 522-525 | 4 | |
| α-helix | 534-537 | 4 | |
| α-helix | 542-554 | 13 | |
| α-helix | 561-564 | 4 | |
| α-helix | 567-579 | 13 | |
| α-helix | 609-623 | 15 | |
| α-helix | 629-649 | 21 | |
| α-helix | 654-673 | 20 | |
| α-helix | 677-680 | 4 | |
| α-helix | 693-709 | 17 | |
| β-strand | 711-712 | 2 | 10 |
| α-helix | 716-740 | 25 | |
| α-helix | 744-764 | 21 | |
| α-helix | 766-771 | 6 | |
| α-helix | 776-782 | 7 | |
| α-helix | 784-789 | 6 | |
| α-helix | 792-804 | 13 | |
| α-helix | 811-814 | 4 | |
| β-strand | 818-819 | 2 | 10 |
| β-strand | 821-824 | 4 | 11 |
| β-strand | 835-838 | 4 | 12 |
| β-strand | 842-852 | 11 | 11 |
| α-helix | 857-860 | 4 | |
| β-strand | 861-866 | 6 | 12 |
| β-strand | 872-874 | 3 | 12 |
| β-strand | 882-883 | 2 | 11 |
| β-strand | 889-899 | 11 | 11 |
| β-strand | 903 | 1 | 13 |
| β-strand | 907-916 | 10 | 12 |
| β-strand | 945-947 | 3 | 12 |
| β-strand | 949 | 1 | 11 |
| β-strand | 952-959 | 8 | 12 |
Chain e: 55 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 28-40 | 13 | |
| α-helix | 52-63 | 12 | |
| α-helix | 67-94 | 28 | |
| α-helix | 118-135 | 18 | |
| α-helix | 137-162 | 26 | |
| α-helix | 172-182 | 11 | |
| α-helix | 185-203 | 19 | |
| α-helix | 205-218 | 14 | |
| α-helix | 220-233 | 14 | |
| α-helix | 235-253 | 19 | |
| α-helix | 291-303 | 13 | |
| α-helix | 307-319 | 13 | |
| α-helix | 339-347 | 9 | |
| α-helix | 349-361 | 13 | |
| α-helix | 367-376 | 10 | |
| α-helix | 381-398 | 18 | |
| α-helix | 403-413 | 11 | |
| α-helix | 429-450 | 22 | |
| α-helix | 467-469 | 3 | |
| α-helix | 472-479 | 8 | |
| α-helix | 481-489 | 9 | |
| α-helix | 495-509 | 15 | |
| α-helix | 515-525 | 11 | |
| α-helix | 529-543 | 15 | |
| α-helix | 549-562 | 14 | |
| α-helix | 568-586 | 19 | |
| α-helix | 590-595 | 6 | |
| α-helix | 599-605 | 7 | |
| α-helix | 607-610 | 4 | |
| α-helix | 611-615 | 5 | |
| α-helix | 619-631 | 13 | |
| α-helix | 633-635 | 3 | |
| α-helix | 641-662 | 22 | |
| α-helix | 664-667 | 4 | |
| α-helix | 668-680 | 13 | |
| α-helix | 682-697 | 16 | |
| α-helix | 702-705 | 4 | |
| α-helix | 727-734 | 8 | |
| α-helix | 769-787 | 19 | |
| β-strand | 788 | 1 | 14 |
| α-helix | 789-790 | 2 | |
| β-strand | 804 | 1 | 14 |
| α-helix | 806-820 | 15 | |
| α-helix | 834-839 | 6 | |
| α-helix | 841-853 | 13 | |
| α-helix | 856-866 | 11 | |
| α-helix | 869-874 | 6 | |
| α-helix | 875-891 | 17 | |
| α-helix | 897-899 | 3 | |
| α-helix | 901-916 | 16 | |
| α-helix | 922-925 | 4 | |
| α-helix | 927-929 | 3 | |
| α-helix | 936-952 | 17 | |
| α-helix | 957-959 | 3 | |
| β-strand | 960-963 | 4 | 15 |
| β-strand | 968-971 | 4 | 15 |
| α-helix | 982-994 | 13 | |
| α-helix | 996-999 | 4 | |
| α-helix | 1001-1006 | 6 | |
Chain f: 32 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-8 | 6 | 16 |
| β-strand | 11 | 1 | 17 |
| α-helix | 12-15 | 4 | |
| β-strand | 17 | 1 | 18 |
| β-strand | 23 | 1 | 18 |
| α-helix | 24-39 | 16 | |
| α-helix | 43-47 | 5 | |
| β-strand | 49-53 | 5 | 16 |
| α-helix | 58-61 | 4 | |
| β-strand | 62-64 | 3 | 16 |
| α-helix | 70-78 | 9 | |
| β-strand | 84 | 1 | 17 |
| α-helix | 88-99 | 12 | |
| α-helix | 103-106 | 4 | |
| β-strand | 115 | 1 | 19 |
| β-strand | 123-130 | 8 | 16 |
| α-helix | 132-134 | 3 | |
| β-strand | 135 | 1 | 20 |
| β-strand | 140 | 1 | 20 |
| α-helix | 151-152 | 2 | |
| α-helix | 155-157 | 3 | |
| β-strand | 166-173 | 8 | 16 |
| α-helix | 183-186 | 4 | |
| α-helix | 188-192 | 5 | |
| α-helix | 196-202 | 7 | |
| β-strand | 207-210 | 4 | 16 |
| α-helix | 213-225 | 13 | |
| β-strand | 230-238 | 9 | 21 |
| α-helix | 260-262 | 3 | |
| β-strand | 265-269 | 5 | 21 |
| α-helix | 283-284 | 2 | |
| β-strand | 285 | 1 | 19 |
| α-helix | 286-287 | 2 | |
| α-helix | 298-302 | 5 | |
| β-strand | 307-314 | 8 | 21 |
| β-strand | 325-329 | 5 | 21 |
| α-helix | 330-331 | 2 | |
| α-helix | 333-339 | 7 | |
| β-strand | 347-352 | 6 | 21 |
| β-strand | 366-370 | 5 | 21 |
| β-strand | 377-381 | 5 | 21 |
| α-helix | 386-399 | 14 | |
| α-helix | 406-417 | 12 | |
| α-helix | 421-423 | 3 | |
| α-helix | 424-434 | 11 | |
| α-helix | 440-443 | 4 | |
| α-helix | 450-473 | 24 | |
| α-helix | 544-546 | 3 | |
| α-helix | 549-551 | 3 | |
| α-helix | 552-563 | 12 | |
| α-helix | 590-596 | 7 | |
| α-helix | 598-599 | 2 | |
| α-helix | 602-603 | 2 | |
12 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Unk-unk-unk-unk-unk-unk-unk-unk-unk | 1 | protein | 9 | Sus scrofa | |
| SOSS complex subunit B1 | B | protein | 213 | Homo sapiens | Q9BQ15 (AlphaFold model) |
| SOSS complex subunit C | C | protein | 106 | Homo sapiens | Q9NRY2 (AlphaFold model) |
| DNA-directed RNA polymerase subunit | Y | protein | 13 | Sus scrofa | I3LJR4 |
| Integrator complex subunit 1 | a | protein | 2192 | Homo sapiens | Q8N201 (AlphaFold model) |
| Integrator complex subunit 2 | b | protein | 1204 | Homo sapiens | Q9H0H0 |
| Integrator complex subunit 3 | c | protein | 1042 | Homo sapiens | Q68E01 |
| Integrator complex subunit 4 | d | protein | 963 | Homo sapiens | Q96HW7 |
| Integrator complex subunit 5 | e | protein | 1021 | Homo sapiens | Q6P9B9 |
| Integrator complex subunit 6 | f | protein | 889 | Homo sapiens | Q9UL03 |
| Integrator complex subunit 7 | g | protein | 964 | Homo sapiens | Q9NVH2 |
| Integrator complex subunit 8 | h | protein | 995 | Homo sapiens | Q75QN2 |
9 more molecules are not listed.
Sequence of entity 1 (1), FASTA
>8RBZ_1 UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK (chains 1)
XXXXXXXXX
Sequence of entity 2 (B), FASTA
>8RBZ_2 SOSS complex subunit B1 (chains B)
SNMTTETFVKDIKPGLKNLNLIFIVLETGRVTKTKDGHEVRTCKVADKTGSINISVWDDV
GNLIQPGDIIRLTKGYASVFKGCLTLYTGRGGDLQKIGEFCMVYSEVPNFSEPNPEYSTQ
QAPNKAVQNDSNPSASQPTTGPSAASPASENQNGNGLSAPPGPGGGPHPPHTPSHPPSTR
ITRSQPNHTPAGPPGPSSNPVSNGKETRRSSKR
Sequence of entity 3 (C), FASTA
>8RBZ_3 SOSS complex subunit C (chains C)
SNMAANSSGQGFQNKNRVAILAELDKEKRKLLMQNQSSTNHPGASIALSRPSLNKDFRDH
AEQQHIAAQQKAALQHAHAHSSGYFITQDSAFGNLILPVLPRLDPE
Sequence of entity 4 (Y), FASTA
>8RBZ_4 DNA-directed RNA polymerase subunit (chains Y)
SPSYSPTSPSYSP
Sequence of entity 5 (a), FASTA
>8RBZ_5 Integrator complex subunit 1 (chains a)
SNMNRAKPTTVRRPSAAAKPSGHPPPGDFIALGSKGQANESKTASTLLKPAPSGLPSERK
RDAAAALSSASALTGLTKRPKLSSTPPLSALGRLAEAAVAEKRAISPSIKEPSVVPIEVL
PTVLLDEIEAAELEGNDDRIEGVLCGAVKQLKVTRAKPDSTLYLSLMYLAKIKPNIFATE
GVIEALCSLLRRDASINFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGER
IWVDSPHCKTFVDNIQTAFNTRMPPRSVLLQGEAGRVAGDLGAGSSPHPSLTEEEDSQTE
LLIAEEKLSPEQEGQLMPRYEELAESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTSTC
GYKEVRLLAVQKLEMWLQNPKLTRPAQDLLMSVCMNCNTHGSEDMDVISHLIKIRLKPKV
LLNHFMLCIRELLSAHKDNLGTTIKLVIFNELSSARNPNNMQVLYTALQHSSELAPKFLA
MVFQDLLTNKDDYLRASRALLREIIKQTKHEINFQAFCLGLMQERKEPQYLEMEFKERFV
VHITDVLAVSMMLGITAQVKEAGIAWDKGEKRNLEVLRSFQNQIAAIQRDAVWWLHTVVP
SISKLAPKDYVHCLHKVLFTEQPETYYKWDNWPPESDRNFFLRLCSEVPILEDTLMRILV
IGLSRELPLGPADAMELADHLVKRAAAVQADDVEVLKVGRTQLIDAVLNLCTYHHPENIQ
LPPGYQPPNLAISTLYWKAWPLLLVVAAFNPENIGLAAWEEYPTLKMLMEMVMTNNYSYP
PCTLTDEETRTEMLNRELQTAQREKQEILAFEGHLAAASTKQTITESSSLLLSQLTSLDP
QGPPRRPPPHILDQVKSLNQSLRLGHLLCRSRNPDFLLHIIQRQASSQSMPWLADLVQSS
EGSLDVLPVQCLCEFLLHDAVDDAASGEEDDEGESKEQKAKKRQRQQKQRQLLGRLQDLL
LGPKADEQTTCEVLDYFLRRLGSSQVASRVLAMKGLSLVLSEGSLRDGEEKEPPMEEDVG
DTDVLQGYQWLLRDLPRLPLFDSVRSTTALALQQAIHMETDPQTISAYLIYLSQHTPVEE
QAQHSDLALDVARLVVERSTIMSHLFSKLSPSAASDAVLSALLSIFSRYVRRMRQSKEGE
EVYSWSESQDQVFLRWSSGETATMHILVVHAMVILLTLGPPRADDSEFQALLDIWFPEEK
PLPTAFLVDTSEEALLLPDWLKLRMIRSEVLRLVDAALQDLEPQQLLLFVQSFGIPVSSM
SKLLQFLDQAVAHDPQTLEQNIMDKNYMAHLVEVQHERGASGGQTFHSLLTASLPPRRDS
TEAPKPKSSPEQPIGQGRIRVGTQLRVLGPEDDLAGMFLQIFPLSPDPRWQSSSPRPVAL
ALQQALGQELARVVQGSPEVPGITVRVLQALATLLSSPHGGALVMSMHRSHFLACPLLRQ
LCQYQRCVPQDTGFSSLFLKVLLQMLQWLDSPGVEGGPLRAQLRMLASQASAGRRLSDVR
GGLLRLAEALAFRQDLEVVSSTVRAVIATLRSGEQCSVEPDLISKVLQGLIEVRSPHLEE
LLTAFFSATADAASPFPACKPVVVVSSLLLQEEEPLAGGKPGADGGSLEAVRLGPSSGLL
VDWLEMLDPEVVSSCPDLQLRLLFSRRKGKGQAQVPSFRPYLLTLFTHQSSWPTLHQCIR
VLLGKSREQRFDPSASLDFLWACIHVPRIWQGRDQRTPQKRREELVLRVQGPELISLVEL
ILAEAETRSQDGDTAACSLIQARLPLLLSCCCGDDESVRKVTEHLSGCIQQWGDSVLGRR
CRDLLLQLYLQRPELRVPVPEVLLHSEGAASSSVCKLDGLIHRFITLLADTSDSRALENR
GADASMACRKLAVAHPLLLLRHLPMIAALLHGRTHLNFQEFRQQNHLSCFLHVLGLLELL
QPHVFRSEHQGALWDCLLSFIRLLLNYRKSSRHLAAFINKFVQFIHKYITYNAPAAISFL
QKHADPLHDLSFDNSDLVMLKSLLAGLSLPSRDDRTDRGLDEEGEEESSAGSLPLVSVSL
FTPLTAAEMAPYMKRLSRGQTVEDLLEVLSDIDEMSRRRPEILSFFSTNLQRLMSSAEEC
CRNLAFSLALRSMQNSPSIAAAFLPTFMYCLGSQDFEVVQTALRNLPEYALLCQEHAAVL
LHRAFLVGMYGQMDPSAQISEALRILHMEAVM
Sequence of entity 6 (b), FASTA
>8RBZ_6 Integrator complex subunit 2 (chains b)
MKDQQTVIMTECTSLQFVSPFAFEAMQKVDVVCLASLSDPELRLLLPCLVRMALCAPADQ
SQSWAQDKKLILRLLSGVEAVNSIVALLSVDFHALEQDASKEQQLRHKLGGGSGESILVS
QLQHGLTLEFEHSDSPRRLRLVLSELLAIMNKVSESNGEFFFKSSELFESPVYLEEAADV
LCILQAELPSLLPIVDVAEALLHVRNGAWFLCLLVANVPDSFNEVCRGLIKNGERQDEES
LGGRRRTDALRFLCKMNPSQALKVRGMVVEECHLPGLGVALTLDHTKNEACEDGVSDLVC
FVSGLLLGTNAKVRTWFGTFIRNGQQRKRETSSSVLWQMRRQLLLELMGILPTVRSTRIV
EEADVDMEPNVSVYSGLKEEHVVKASALLRLYCALMGIAGLKPTEEEAEQLLQLMTSRPP
ATPAGVRFVSLSFCMLLAFSTLVSTPEQEQLMVVWLSWMIKEEAYFESTSGVSASFGEML
LLVAMYFHSNQLSAIIDLVCSTLGMKIVIKPSSLSRMKTIFTQEIFTEQVVTAHAVRVPV
TSNLSANITGFLPIHCIYQLLRSRSFTKHKVSIKDWIYRQLCETSTPLHPQLLPLIDVYI
NSILTPASKSNPEATNQPVTEQEILNIFQGVIGGDNIRLNQRFSITAQLLVLYYILSYEE
ALLANTKTLAAMQRKPKSYSSSLMDQIPIKFLIRQAQGLQQELGGLHSALLRLLATNYPH
LCIVDDWICEEEITGTDALLRRMLLTNNAKNHSPKQLQEAFSAVPVNNTQVMQIIEHLTL
LSASELIPYAEVLTSNMSQLLNSGVPRRILQTVNKLWMVLNTVMPRRLWVMTVNALQPSI
KFVRQQKYTQNDLMIDPLIVLRCDQRVHRCPPLMDITLHMLNGYLLASKAYLSAHLKETE
QDRPSQNNTIGLVGQTDAPEVTREELKNALLAAQDSAAVQILLEICLPTEEEKANGVNPD
SLLRNVQSVITTSAPNKGMEEGEDNLLCNLREVQCLICCLLHQMYIADPNIAKLVHFQGY
PCELLPLTVAGIPSMHICLDFIPELIAQPELEKQIFAIQLLSHLCIQYALPKSLSVARLA
VNVMGTLLTVLTQAKRYAFFMPTLPSLVSFCRAFPPLYEDIMSLLIQIGQVCASDVATQT
RDIDPIITRLQQIKEKPSGWSQICKDSSYKNGSRDTGSMDPDVQLCHCIERTVIEIINMS
VSGI
Sequence of entity 7 (c), FASTA
>8RBZ_7 Integrator complex subunit 3 (chains c)
MELQKGKGAAAAAAASGAAGGGGGGAGAGAPGGGRLLLSTSLDAKDELEERLERCMSIVT
SMTAGVSEREANDALNAYVCKGLPQHEEICLGLFTLILTEPAQAQKCYRDLALVSRDGMN
IVLNKINQILMEKYLKLQDTCRTQLVWLVRELVKSGVLGADGVCMTFMKQIAGGDVTAKN
IWLAESVLDILTEQREWVLKSSILIAMAVYTYLRLIVDHHGTAQLQALRQKEVDFCISLL
RERFMECLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQSRTSRKF
LACRLTPDMETKLLFMTSRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPS
NEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVMH
HSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPK
LDKELRAMLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEE
DLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDESLRDKVLQLQKGSDTEAQCEVMQE
IVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLC
QMQEDNSSFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLH
TCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSGELLNMIVAVIDSAQLQELVCHVM
MGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEAL
SCLLLQLRREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNS
LPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNTKQNFFSQTPILQALQHVQASCDE
AHKMKFSDLFSLAEEYEDSSTKPPKSRRKAALSSPRSRKNATQPPNAEEESGSSSASEEE
DTKPKPTKRKRKGSSAVGSDSD
Sequence of entity 8 (d), FASTA
>8RBZ_8 Integrator complex subunit 4 (chains d)
MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFA
RKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQN
EKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSL
EKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKL
LSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRV
QAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPK
EEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMF
NDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKE
GIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMD
DPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVS
PSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFS
ATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVV
IIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKL
LDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSG
LVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSH
TAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKP
ARR
Sequence of entity 9 (e), FASTA
>8RBZ_9 Integrator complex subunit 5 (chains e)
SNMSALCDPPGAPGPPGPAPATHGPAPLSAQELSQEIKAFLTGVDPILGHQLSAREHARC
GLLLLRSLPPARAAVLDHLRGVFDESVRAHLAALDETPVAGPPHLRPPPPSHVPAGGPGL
EDVVQEVQQVLSEFIRANPKAWAPVISAWSIDLMGQLSSTYSGQHQRVPHATGALNELLQ
LWMGCRATRTLMDIYVQCLSALIGSCPDACVDALLDTSVQHSPHFDWVVAHIGSSFPGTI
ISRVLSCGLKDFCVHGGAGGGAGSSGGSSSQTPSTDPFPGSPAIPAEKRVPKIASVVGIL
GHLASRHGDSIRRELLRMFHDSLAGGSGGRSGDPSLQATVPFLLQLAVMSPALLGTVSGE
LVDCLKPPAVLSQLQQHLQGFPREELDNMLNLAVHLVSQASGAGAYRLLQFLVDTAMPAS
VITTQGLAVPDTVREACDRLIQLLLLHLQKLVHHRGGSPGEGVLGPPPPPRLVPFLDALK
NHVGELCGETLRLERKRFLWQHQLLGLLSVYTRPSCGPEALGHLLSRARSPEELSLATQL
YAGLVVSLSGLLPLAFRSCLARVHAGTLQPPFTARFLRNLALLVGWEQQGGEGPAALGAH
FGESASAHLSDLAPLLLHPEEEVAEAAASLLAICPFPSEALSPSQLLGLVRAGVHRFFAS
LRLHGPPGVASACQLLTRLSQTSPAGLKAVLQLLVEGALHRGNTELFGGQVDGDNETLSV
VSASLASASLLDTNRRHTAAVPGPGGIWSVFHAGVIGRGLKPPKFVQSRNQQEVIYNTQS
LLSLLVHCCSAPGGTECGECWGAPILSPEAAKAVAVTLVESVCPDAAGAELAWPPEEHAR
ATVERDLRIGRRFREQPLLFELLKLVAAAPPALCYCSVLLRGLLAALLGHWEASRHPDTT
HSPWHLEASCTLVAVMAEGSLLPPALGNMHEVFSQLAPFEVRLLLLSVWGFLREHGPLPQ
KFIFQSERGRFIRDFSREGGGEGGPHLAVLHSVLHRNIDRLGLFSGRFQAPSPSTLLRQG
T
Sequence of entity 10 (f), FASTA
>8RBZ_10 Integrator complex subunit 6 (chains f)
SNMPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEP
PYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPF
FLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGT
MSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKA
GPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTL
PPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKY
SELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKT
MPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKV
VQETGIKVRSRSHGLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKP
QTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVP
SPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPNMQGIPKRRR
CMSPLLRGRQQNPVVNNHIGGKGPPAPTTQAQPDLIKPLPLHKISETTNDSIIHDVVENH
VADQLSSDITPNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPR
DKEQCAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQ
GSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN
Sequence of entity 11 (g), FASTA
>8RBZ_11 Integrator complex subunit 7 (chains g)
SNMASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFP
ILINSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVA
RAITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICN
KISEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQLVTSYPSTKMVIVSLHTF
TLLAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAIQDLKLLANKTPHTWSRENIQALCEC
ALQTPYDSLKLGMLSVLSTLSGTIAIKHYFSIVPGNVSSSPRSSDLVKLAQECCYHNNRG
IAAHGVRVLTNITVSCQEKDLLALEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVK
LAKGRPHLSQSVVETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVI
GRSATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIARQASRMGN
HDMAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEENYSSALSCIAESLKFYH
KGIASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLG
NDLQRCGRISNQMKQSMEEFRSLASRYGDLYQASFDADSATLRNVELQQQSCLLISHAIE
ALILDPESASFQEYGSTGTAHADSEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLC
NAIIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRNPAEPIAVQNNQQLALKVEGVVQHG
SKPGLFRKIQSVCLNVSSTLQSKSGQDYKIPIDNMTNEMEQRVEPHNDYFSTQFLLNFAI
LGTHNITVESSVKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQAQQPLQQQQQRNA
YTRF
Sequence of entity 12 (h), FASTA
>8RBZ_12 Integrator complex subunit 8 (chains h)
MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFLEQASK
PSVNEQNQVQPPPDNKRNRILKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISK
VPPGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAKPGPPQLSVMNQMQQE
KELTENILKVLKEQAADSILVLEAALKLNKDLYVHTMRTLDLLAMEPGMVNGETESSTAG
LKVKTEEMQCQVCYDLGAAYFQQGSTNSAVYENAREKFFRTKELIAEIGSLSLHCTIDEK
RLAGYCQACDVLVPSSDSTSQQLTPYSQVHICLRSGNYQEVIQIFIEDNLTLSLPVQFRQ
SVLRELFKKAQQGNEALDEICFKVCACNTVRDILEGRTISVQFNQLFLRPNKEKIDFLLE
VCSRSVNLEKASESLKGNMAAFLKNVCLGLEDLQYVFMISSHELFITLLKDEERKLLVDQ
MRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSVDPWRIRQILIELHGMTSERQ
FWTVSNKWEVPSVYSGVILGIKDNLTRDLVYILMAKGLHCSTVKDFSHAKQLFAACLELV
TEFSPKLRQVMLNEMLLLDIHTHEAGTGQAGERPPSDLISRVRGYLEMRLPDIPLRQVIA
EECVAFMLNWRENEYLTLQVPAFLLQSNPYVKLGQLLAATCKELPGPKESRRTAKDLWEV
VVQICSVSSQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKL
HNVREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHSWLIIQA
DIYFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAIL
CQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKA
IGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLYF
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 2 |
| MN | Manganese (II) ion | Mn | 2 |
Primary citation
Structural basis of Integrator-dependent RNA polymerase II termination. Fianu, I., Ochmann, M., Walshe, J.L. et al. Nature (2024) 629:219-227. DOI 10.1038/s41586-024-07269-4 · PubMed
Other PDB entries of the same protein (UniProt Q9BQ15 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4OWT 2.0 Å, Structural basis of SOSS1 complex assembly
- 4OWW 2.3 Å, Structural basis of SOSS1 in complex with a 35nt ssDNA
- 4OWX 2.3 Å, Structural basis of SOSS1 in complex with a 12nt ssDNA
- 5D8F 2.35 Å, crystal structure of SSB and ssDNA complex from homo sapiens
- 5D8E 3.0 Å, crystal structure of SSB from homo sapiens
Browse structure collections
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