crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1). Determined by X-ray diffraction at 3.05 Å resolution. Released 27 Aug 2014.
Explore 4PJU in 3D Show helices and sheets RCSB PDB PDBe
4PJU contains 60 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 84-90 | 7 | |
| α-helix | 95-108 | 14 | |
| α-helix | 110-123 | 14 | |
| α-helix | 133-138 | 6 | |
| α-helix | 141-150 | 10 | |
| α-helix | 166-185 | 20 | |
| α-helix | 190-192 | 3 | |
| α-helix | 196-207 | 12 | |
| β-strand | 212 | 1 | 1 |
| α-helix | 213-250 | 38 | |
| α-helix | 262-288 | 27 | |
| α-helix | 289-293 | 5 | |
| α-helix | 294-296 | 3 | |
| β-strand | 299 | 1 | 2 |
| α-helix | 302-318 | 17 | |
| α-helix | 320-323 | 4 | |
| α-helix | 326-335 | 10 | |
| α-helix | 341-352 | 12 | |
| α-helix | 362-370 | 9 | |
| α-helix | 372-377 | 6 | |
| α-helix | 378-380 | 3 | |
| β-strand | 381 | 1 | 3 |
| α-helix | 384-400 | 17 | |
| α-helix | 407-414 | 8 | |
| α-helix | 415-418 | 4 | |
| β-strand | 419 | 1 | 4 |
| α-helix | 422-436 | 15 | |
| α-helix | 458-470 | 13 | |
| α-helix | 478-483 | 6 | |
| α-helix | 489-492 | 4 | |
| α-helix | 495-503 | 9 | |
| α-helix | 515-533 | 19 | |
| α-helix | 537-538 | 2 | |
| α-helix | 550-578 | 29 | |
| α-helix | 582-589 | 8 | |
| α-helix | 591-594 | 4 | |
| α-helix | 598-600 | 3 | |
| α-helix | 606-622 | 17 | |
| α-helix | 626-639 | 14 | |
| α-helix | 647-672 | 26 | |
| α-helix | 681-700 | 20 | |
| α-helix | 709-722 | 14 | |
| α-helix | 727-746 | 20 | |
| α-helix | 757-775 | 19 | |
| α-helix | 781-797 | 17 | |
| α-helix | 811-813 | 3 | |
| α-helix | 819-832 | 14 | |
| α-helix | 855-873 | 19 | |
| α-helix | 879-882 | 4 | |
| α-helix | 883-886 | 4 | |
| α-helix | 897-908 | 12 | |
| α-helix | 912-930 | 19 | |
| α-helix | 943-956 | 14 | |
| α-helix | 968-981 | 14 | |
| α-helix | 999-1003 | 5 | |
| α-helix | 1004-1006 | 3 | |
| α-helix | 1012-1022 | 11 | |
| α-helix | 1039-1046 | 8 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 326 | 1 | 1 |
| β-strand | 331 | 1 | 2 |
| α-helix | 334-342 | 9 | |
| α-helix | 345-347 | 3 | |
| β-strand | 348 | 1 | 3 |
| β-strand | 353 | 1 | 4 |
| α-helix | 354-355 | 2 | |
| α-helix | 358-365 | 8 | |
| α-helix | 369-372 | 4 | |
| α-helix | 383-390 | 8 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Cohesin subunit SA-2 | A | protein | 981 | Homo sapiens | Q8N3U4 (AlphaFold model) |
| Double-strand-break repair protein rad21 homolog | B | protein | 140 | Homo sapiens | O60216 (AlphaFold model) |
>4PJU_1 Cohesin subunit SA-2 (chains A) ENMMLFEVVKMGKSAMQSVVDDWIESYKHDRDIALLDLINFFIQCSGCKGVVTAEMFRHM QNSEIIRKMTEEFDEDSGDYPLTMAGPQWKKFKSSFCEFIGVLVRQCQYSIIYDEYMMDT VISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSINMDNTQRQYEAERNKMIGKR ANERLELLLQKRKELQENQDEIENMMNAIFKGVFVHRYRDAIAEIRAICIEEIGIWMKMY SDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYYNKELNSKLELFTSRFKDRIVSMT LDKEYDVAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGEFLYKKLFSR RDPEEDGMMKRRGRQGPNANLVKTLVFFFLESELHEHAAYLVDSMWDCATELLKDWECMN SLLLEEPLSGEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGKRVLTAKEKKTQLDD RTKITELFAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLEKHLDALLRQIRNI VEKHTDTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDELADKFNRLLEDFLQEGEEP DEDDAYQVLSTLKRITAFHNAHDLSKWDLFACNYKLLKTGIENGDMPEQIVIHALQCTHY VILWQLAKITESSSTKEDLLRLKKQMRVFCQICQHYLTNVNTTVKEQAFTILCDILMIFS HQIMSGGRDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDDNNSADGQQEDEASKIEALH KRRNLLAAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQCAKTL ILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFGLDQLKTREAIAMLHKDGIE FAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVYVYLEKFMTFQMSLRREDVWL PLMSYRNSLLAGGDDDTMSVI
>4PJU_2 Double-strand-break repair protein rad21 homolog (chains B) VDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQ LSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPED LRKRRKGGEADNLDEFLKEF
Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion. Hara, K., Zheng, G., Qu, Q. et al. Nat Struct Mol Biol (2014) 21:864-870. DOI 10.1038/nsmb.2880 · PubMed
Other PDB entries of the same protein (UniProt Q8N3U4 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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