4PW6: UHRF2-SRA

structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex II. Determined by X-ray diffraction at 3.79 Å resolution. Released 7 May 2014.

Method: X-ray diffraction
Resolution: 3.79 Å
Organism: Homo sapiens
Chains: 4
Atoms: 3,468
Mol. weight: 58.51 kDa
Released: 7 May 2014

Explore 4PW6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4PW6 contains 20 α-helices and 20 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 10 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	449-450	2
β-strand	458-459	2	1
α-helix	462-468	7
β-strand	478-481	4	1
β-strand	485-491	7	1
β-strand	500	1	1
β-strand	504-508	5	1
α-helix	533-539	7
β-strand	551-552	2	1
α-helix	556-558	3
α-helix	560-561	2
β-strand	562-567	6	1
α-helix	568-572	5
β-strand	582-597	16	1
β-strand	604-612	9	1
α-helix	617-618	2
α-helix	622-630	9
α-helix	635	1
β-strand	636	1	1
α-helix	637-638	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
E3 ubiquitin-protein ligase UHRF2	A, B	protein	230	Homo sapiens	Q96PU4 (AlphaFold model)
5hmC-containing DNA1	C	DNA	12
5hmC-containing DNA2	D	DNA	12

Sequence of entity 1 (A, B), FASTA

>4PW6_1 E3 ubiquitin-protein ligase UHRF2 (chains A, B)
STESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGI
HGRSNDGAYSLVLAGGFADEVDRGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALA
LNCDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEIS
SSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGK

Sequence of entity 2 (C), FASTA

>4PW6_2 5hmC-containing DNA1 (chains C)
GTGATXGAAGTT

Sequence of entity 3 (D), FASTA

>4PW6_3 5hmC-containing DNA2 (chains D)
AACTTCGATCAC

Primary citation

Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2. Zhou, T., Xiong, J., Wang, M. et al. Mol Cell (2014) 54:879-886. DOI 10.1016/j.molcel.2014.04.003 · PubMed

Other PDB entries of the same protein (UniProt Q96PU4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4PW7 2.0 Å, structure of UHRF2-SRA in complex with a 5mC-containing DNA
1Z6U 2.1 Å, Np95-like ring finger protein isoform b [Homo sapiens]
5YCO 2.2 Å, Complex structure of PCNA with UHRF2
4PW5 2.2 Å, structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex I
4TVR 2.29 Å, Tandem Tudor and PHD domains of UHRF2
3OLN 2.3 Å, Crystal structure of the SRA domain of E3 ubiquitin-protein ligase UHRF2
1WY8 Solution Structure of the N-terminal Ubiquitin-like Domain in Human Np95/ICBP90-like…
2E6S Solution structure of the PHD domain in RING finger protein 107

Browse structure collections

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