Crystal structure of the first bromodomain of human BRD4 in complex with Olinone. Determined by X-ray diffraction at 0.94 Å resolution. Released 22 Apr 2015.
Explore 4QB3 in 3D Show helices and sheets RCSB PDB PDBe
4QB3 contains 11 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 43-49 | 7 | |
| α-helix | 61-65 | 5 | |
| α-helix | 66-71 | 6 | |
| α-helix | 72-75 | 4 | |
| α-helix | 81-83 | 3 | |
| α-helix | 97-100 | 4 | |
| α-helix | 107-115 | 9 | |
| α-helix | 122-139 | 18 | |
| α-helix | 141 | 1 | |
| α-helix | 145-161 | 17 | |
| α-helix | 164-167 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Bromodomain-containing protein 4 | A | protein | 127 | Homo sapiens | O60885 (AlphaFold model) |
>4QB3_1 Bromodomain-containing protein 4 (chains A) SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPTEE
| ID | Name | Formula | Copies |
|---|---|---|---|
| 30M | N-[4-(1-oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl]acetamide | C17 H21 N3 O2 | 1 |
Water and common crystallization additives (EDO) are not listed.
Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression. Gacias, M., Gerona-Navarro, G., Plotnikov, A.N. et al. Chem Biol (2014) 21:841-854. DOI 10.1016/j.chembiol.2014.05.009 · PubMed
Other PDB entries of the same protein (UniProt O60885 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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