4UDA: Mineralocorticoid receptor

MR in complex with dexamethasone. Determined by X-ray diffraction at 2.03 Å resolution. Released 25 Nov 2015.

Method: X-ray diffraction
Resolution: 2.03 Å
Organism: HOMO SAPIENS
Chains: 2
Atoms: 2,215
Mol. weight: 31.37 kDa
Ligands: DEX
Released: 25 Nov 2015

Explore 4UDA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4UDA contains 13 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	739-745	7
α-helix	746-749	4
α-helix	762-785	24
α-helix	790-792	3
α-helix	795-822	28
β-strand	827-830	4	1
β-strand	833-835	3	1
α-helix	837-842	6
α-helix	846-862	17
α-helix	866-877	12
β-strand	880-882	3	2
α-helix	889-907	19
α-helix	916-947	32
α-helix	949-952	4
α-helix	958-972	15
β-strand	976-978	3	2

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	1434-1439	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Mineralocorticoid receptor	A	protein	251	HOMO SAPIENS	P08235 (AlphaFold model)
Nuclear receptor coactivator 1	B	protein	15	HOMO SAPIENS	Q15788 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4UDA_1 MINERALOCORTICOID RECEPTOR (chains A)
GTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNL
PLEDQITLIQYSWMSLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMH
QISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKSPNN
SGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVES
GNAKPLYFHRK

Sequence of entity 2 (B), FASTA

>4UDA_2 NUCLEAR RECEPTOR COACTIVATOR 1 (chains B)
PQAQQKSLLQQLLTE

Ligands and cofactors

ID	Name	Formula	Copies
DEX	Dexamethasone	C22 H29 F O5	1

Water and common crystallization additives (GOL) are not listed.

Primary citation

Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints. Edman, K., Hosseini, A., Bjursell, M.K. et al. Structure (2015) 23:2280. DOI 10.1016/J.STR.2015.09.012 · PubMed

Other PDB entries of the same protein (UniProt P08235 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4PF3 1.1 Å, Mineralocorticoid receptor ligand-binding domain with compuond 37a
3VHV 1.35 Å, Mineralocorticoid receptor ligand-binding domain with non-steroidal antagonist
3WFG 1.4 Å, Mineralocorticoid receptor ligand-binding domain with compuond 2e
9GC7 1.46 Å, Mineralocorticoid receptor in complex with acylurea antagonists.
6GEV 1.54 Å, Mineralocorticoid receptor in complex with (s)-13
6GGG 1.71 Å, Mineralocorticoid receptor in complex with (s)-13
2AAX 1.75 Å, Mineralocorticoid Receptor Double Mutant with Bound Cortisone
5MWY 1.75 Å, The structure of MR in complex with eplerenone.
6GG8 1.8 Å, Mineralocorticoid receptor in complex with (s)-13
5MWP 1.82 Å, The structure of MR in complex with AZD9977.
5L7H 1.84 Å, MCR IN COMPLEX WITH ligand
2AB2 1.85 Å, Mineralocorticoid Receptor Double Mutant with Bound Spironolactone

Browse structure collections

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