4UE4: Ftsq signal sequence

Name: PDB 4UE4: Structural basis for targeting and elongation arrest of Bacillus signal recognition particle
Published: 2015-09-09
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: translation

Structural basis for targeting and elongation arrest of Bacillus signal recognition particle. Determined by electron microscopy at 7.0 Å resolution. Released 9 Sept 2015.

Method: Electron microscopy
Resolution: 7.0 Å
Organism: BACILLUS SUBTILIS SUBSP. SUBTILIS STR. 168
Chains: 3
Atoms: 6,181
Mol. weight: 100.04 kDa
Released: 9 Sept 2015

Explore 4UE4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4UE4 contains 7 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	11-27	17

Chain C: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	331-344	14
α-helix	376-382	7
α-helix	385-389	5
α-helix	391-393	3
α-helix	396-406	11
α-helix	410-429	20

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
6S RNA	A	RNA	266	BACILLUS SUBTILIS SUBSP. SUBTILIS STR. 168
Ftsq signal sequence	B	protein	22	BACILLUS SUBTILIS SUBSP. SUBTILIS STR. 168	P06136 (AlphaFold model)
Signal recognition particle protein	C	protein	102	BACILLUS SUBTILIS SUBSP. SUBTILIS STR. 168	P37105 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4UE4_1 6S RNA (chains A)
GCCGUGCUAAGCGGGGAGGUAGCGGUGCCCUGUACCUGCAAUCCGCUCUAGCAGGGCCGA
AUCCCUUCUCGAGGUUCGUUUACUUUAAGGCCUGCCUUAAGUAAGUGGUGUUGACGUUUG
GGUCCUGCGCAAUGGGAAUUCAUGAACCAUGUCAGGUCCGGAAGGAAGCAGCAUUAAGUG
AAACCUCUCAUGUGCCGCAGGGUUGCCUGGGCCGAGCUAACUGCUUAAGUAACGCUAGGG
UAGCGAAUCGACAGAAGGUGCACGGU

Sequence of entity 2 (B), FASTA

>4UE4_2 FTSQ SIGNAL SEQUENCE (chains B)
LFLLTVCTTVLVSGWVVLGWME

Sequence of entity 3 (C), FASTA

>4UE4_3 SIGNAL RECOGNITION PARTICLE PROTEIN (chains C)
TLDDFLEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKE
QPDIINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMT

Primary citation

Translational Arrest by a Prokaryotic Signal Recognition Particle is Mediated by RNA Interactions. Beckert, B., Kedrov, A., Sohmen, D. et al. Nat Struct Mol Biol (2015) 22:767. DOI 10.1038/NSMB.3086 · PubMed

Other PDB entries of the same protein (UniProt P06136 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6H9N 2.6 Å, Complex of the periplasmic domains of bacterial cell division proteins FtsQ and FtsB
2VH1 2.7 Å, Crystal structure of bacterial cell division protein FtsQ from E.coli
6H9O 2.8 Å, Complex of the periplasmic domains of bacterial cell division proteins FtsQ and FtsB
5Z2W 3.0 Å, Crystal structure of the bacterial cell division protein FtsQ and FtsB
8HHF 3.04 Å, The bacterial divisome protein complex FtsB-FtsL-FtsQ
8HHG 3.1 Å, The bacterial divisome protein complex FtsB-FtsL-FtsQ
8YA3 3.27 Å, Structure of the SecA-SecY complex with the substrate FtsQ-LacY(+7C) treated with DTT
8Y9Y 3.29 Å, Structure of the SecA-SecY complex with the substrate FtsQ-LacY(+1C)
8HHH 3.3 Å, The bacterial divisome protein complex FtsB-FtsL-FtsQ
8YA2 3.84 Å, Structure of the SecA-SecY complex with the substrate FtsQ-LacY(+20C)

Browse structure collections

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