4ZI1: Estrogen receptor beta

Human estrogen receptor beta ligand-binding domain in complex with KB095285 and CIA12 coactivator peptide. Determined by X-ray diffraction at 2.1 Å resolution. Released 29 Jun 2016.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,122
Mol. weight: 29.63 kDa
Ligands: KB0
Released: 29 Jun 2016

Explore 4ZI1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4ZI1 contains 14 α-helices and 2 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	265-275	11
α-helix	276-280	5
α-helix	288-289	2
α-helix	291-314	24
α-helix	319-321	3
α-helix	324-347	24
β-strand	353-357	5	1
β-strand	360-363	4	1
α-helix	364-369	6
α-helix	374-390	17
α-helix	394-406	13
α-helix	421-442	22
α-helix	448-481	34
α-helix	489-496	8
α-helix	498-501	4

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	345-350	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Estrogen receptor beta	A	protein	249	Homo sapiens	Q92731 (AlphaFold model)
Nuclear receptor coactivator 5	B	protein	12	Homo sapiens	Q9HCD5 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4ZI1_1 Estrogen receptor beta (chains A)
MALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFV
ELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDML
LATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWV
IAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVL
RGDKSSITG

Sequence of entity 2 (B), FASTA

>4ZI1_2 Nuclear receptor coactivator 5 (chains B)
AIESLIDLLADN

Ligands and cofactors

ID	Name	Formula	Copies
KB0	2-(4-hydroxyphenyl)-7-methyl-3-phenyl-1H-inden-5-ol	C22 H18 O2	1

Primary citation

HUMAN ESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH KB095285 AND CIA12 COACTIVATOR PEPTIDE. Kauppi, B., Bonn, T. To be published.

Other PDB entries of the same protein (UniProt Q92731 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3OLL 1.5 Å, Crystal structure of phosphorylated estrogen receptor beta ligand binding domain
7XVY 1.54 Å, Human Estrogen Receptor beta Ligand-binding Domain in Complex with S-DPN
1QKM 1.8 Å, Human oestrogen receptor beta ligand-binding domain in complex with partial agonist…
7XWQ 1.89 Å, Human Estrogen Receptor beta Ligand-binding Domain in Complex with…
7XWP 1.92 Å, Human Estrogen Receptor beta Ligand-binding Domain in Complex with…
2YJD 1.93 Å, Stapled peptide bound to Estrogen Receptor Beta
3OMQ 1.97 Å, Fragment-Based Design of novel Estrogen Receptor Ligands
9ECF 2.0 Å, Crystal structure of the hERbeta LBD complexed with androstenediol and SRC 2-2 peptide…
1YYE 2.03 Å, Crystal structure of estrogen receptor beta complexed with way-202196
3OMP 2.05 Å, Fragment-Based Design of novel Estrogen Receptor Ligands
7XVZ 2.08 Å, Human Estrogen Receptor beta Ligand-binding Domain in Complex with…
2NV7 2.1 Å, Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555

Browse structure collections

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