5BRK: PMob1-Lats1 complex

pMob1-Lats1 complex. Determined by X-ray diffraction at 2.3 Å resolution. Released 8 Jul 2015.

Method: X-ray diffraction
Resolution: 2.3 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,198
Mol. weight: 39.12 kDa
Ligands: ZN
Released: 8 Jul 2015

Explore 5BRK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5BRK contains 11 α-helices and 5 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	13-15	3	1
α-helix	41-44	4
α-helix	47-48	2
α-helix	53-75	23
β-strand	88	1	1
β-strand	93-95	3	1
β-strand	96-97	2	2
β-strand	107-108	2	2
α-helix	111-127	17
α-helix	139-141	3
α-helix	144-172	29
α-helix	176-193	18
α-helix	202-204	3
α-helix	205-211	7

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	637-671	35
α-helix	675-697	23

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MOB kinase activator 1A	A	protein	217	Homo sapiens	Q9H8S9 (AlphaFold model)
Serine/threonine-protein kinase LATS1	B	protein	111	Homo sapiens	O95835 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5BRK_1 MOB kinase activator 1A (chains A)
GMSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAV
NTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLM
TWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHL
NTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR

Sequence of entity 2 (B), FASTA

>5BRK_2 Serine/threonine-protein kinase LATS1 (chains B)
MHHHHHHGSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKS
HQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSM

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Primary citation

Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling. Ni, L., Zheng, Y., Hara, M. et al. Genes Dev (2015) 29:1416-1431. DOI 10.1101/gad.264929.115 · PubMed

Other PDB entries of the same protein (UniProt Q9H8S9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4J1V 1.95 Å, Functional and structural studies of MOBKL1B, a Salvador/Warts/Hippo tumor suppressor…
1PI1 2.0 Å, Crystal structure of a human Mob1 protein; toward understanding Mob-regulated cell cycle…
4JIZ 2.1 Å, Human Mob1-phosphopeptide complex
5XQZ 2.1 Å, Structure of the MOB1-NDR2 complex
5TWG 2.3 Å, human MOB1A bound to human MST1 phosphorylated T353 peptide
5TWH 2.5 Å, human MOB1A bound to MST1 phosphorylated T367 peptide
6MCP 2.5 Å, L. pneumophila effector kinase LegK7 (AMP-PNP bound) in complex with human MOB1A
6MCQ 2.57 Å, L. pneumophila effector kinase LegK7 in complex with human MOB1A
5BRM 2.65 Å, Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in…
5TWF 3.14 Å, Regulation of protein interactions by MOB1 phosphorylation

Browse structure collections

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