5CTQ: Human SART3/TIP110 half-a TPR (HAT) domain

Crystal structure of human SART3/TIP110 half-a TPR (HAT) domain. Determined by X-ray diffraction at 2.6 Å resolution. Released 27 Apr 2016.

Method
X-ray diffraction
Resolution
2.6 Å
Organism
Homo sapiens
Chains
4
Atoms
16,916
Mol. weight
263.28 kDa
Released
27 Apr 2016

Explore 5CTQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5CTQ contains 125 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 30 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix95-10713
α-helix112-12514
α-helix128-14114
α-helix143-1453
α-helix146-15914
α-helix163-17917
α-helix183-19311
α-helix194-1963
α-helix202-21716
α-helix225-23814
α-helix244-25512
α-helix262-27211
α-helix279-30426
α-helix310-32314
α-helix326-33914
α-helix344-35310
α-helix354-3585
α-helix361-37414
α-helix379-39113
α-helix396-40914
α-helix414-42916
α-helix440-45516
α-helix456-4605
α-helix461-4644
α-helix473-48412
α-helix489-50113
α-helix508-52114
α-helix524-53714
α-helix542-55615
α-helix559-60345
Chain B: 33 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix95-10713
α-helix112-12514
α-helix128-13912
α-helix143-1453
α-helix146-15813
α-helix166-17611
α-helix183-19311
α-helix194-1963
α-helix202-21716
α-helix225-23814
α-helix244-25512
α-helix263-27210
α-helix276-2783
α-helix279-30426
α-helix3061
α-helix310-32314
α-helix326-33914
α-helix344-35310
α-helix354-3585
α-helix361-37414
α-helix379-39113
α-helix396-40712
α-helix414-42916
α-helix440-45516
α-helix456-4605
α-helix461-4644
α-helix473-48412
α-helix489-49911
α-helix500-5045
α-helix508-52114
α-helix524-53714
α-helix542-55615
α-helix559-58224
Chain C: 32 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix95-10713
α-helix112-12514
α-helix128-13912
α-helix143-1453
α-helix146-15914
α-helix164-17916
α-helix183-19412
α-helix202-21716
α-helix225-23713
α-helix244-25411
α-helix262-27211
α-helix276-2783
α-helix279-30426
α-helix3061
α-helix310-32314
α-helix326-33914
α-helix344-35310
α-helix354-3585
α-helix361-37414
α-helix379-39113
α-helix396-40712
α-helix414-42916
α-helix440-45516
α-helix456-4605
α-helix461-4644
α-helix473-48412
α-helix489-49911
α-helix500-5045
α-helix508-52114
α-helix524-53714
α-helix542-55615
α-helix559-58729
Chain D: 30 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix95-10713
α-helix112-12514
α-helix128-13912
α-helix143-1453
α-helix146-15914
α-helix163-17917
α-helix183-19311
α-helix194-1963
α-helix202-21716
α-helix224-23714
α-helix244-25512
α-helix263-27210
α-helix279-30426
α-helix310-32314
α-helix326-33914
α-helix344-35310
α-helix354-3585
α-helix361-37414
α-helix379-39113
α-helix396-40712
α-helix414-42916
α-helix440-45516
α-helix456-4605
α-helix461-4644
α-helix473-48412
α-helix489-50113
α-helix508-52114
α-helix524-53714
α-helix542-55514
α-helix559-59436

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Squamous cell carcinoma antigen recognized by T-cells 3A, B, C, Dprotein561Homo sapiensQ15020 (AlphaFold model)
Sequence of entity 1 (A, B, C, D), FASTA
>5CTQ_1 Squamous cell carcinoma antigen recognized by T-cells 3 (chains A, B, C, D)
MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSEFENLYFQGNQLEIERLEEQLSINVY
DYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVY
DLFEKAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEA
YREFESAIVEAARLEKVHSLFRRQLAIPLYDMEATFAEYEEWSEDPIPESVIQNYNKALQ
QLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLWIRY
SQYLDRQLKVKDLVLSVHNRAIRNCPWTVALWSRYLLAMERHGVDHQVISVTFEKALNAG
FIQATDYVEIWQAYLDYLRRRVDFKQDSSKELEELRAAFTRALEYLKQEVEERFNESGDP
SCVIMQNWARIEARLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKA
LHRAVQCTSDYPEHVCEVLLTMERTEGSLEDWDIAVQKTETRLARVNEQRMKAAEKEAAL
VQQEEEKAEQRKRARAEKKAL

Primary citation

Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3. Park, J.K., Das, T., Song, E.J. et al. Nucleic Acids Res (2016) 44:5424-5437. DOI 10.1093/nar/gkw218 · PubMed

Other PDB entries of the same protein (UniProt Q15020 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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