5EFM: Beclin 1 Flexible-helical Domian (FHD)

Beclin 1 Flexible-helical Domian (FHD) (141-171). Determined by X-ray diffraction at 1.95 Å resolution. Released 20 Jul 2016.

Method: X-ray diffraction
Resolution: 1.95 Å
Organism: Homo sapiens
Chains: 1
Atoms: 154
Mol. weight: 3.78 kDa
Released: 20 Jul 2016

Explore 5EFM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5EFM contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	160-169	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Beclin-1	A	protein	31	Homo sapiens	Q14457 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5EFM_1 Beclin-1 (chains A)
TDTLLDQLDTQLNVTENECQNYKRCLEILEQ

Primary citation

Conformational Flexibility Enables the Function of a BECN1 Region Essential for Starvation-Mediated Autophagy. Mei, Y., Ramanathan, A., Glover, K. et al. Biochemistry (2016) 55:1945-1958. DOI 10.1021/acs.biochem.5b01264 · PubMed

Other PDB entries of the same protein (UniProt Q14457 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6HOI 1.14 Å, Structure of Beclin1 LIR motif bound to GABARAPL1
5HHE 1.46 Å, Human Beclin 1 coiled-coil domain
6HOJ 1.51 Å, Structure of Beclin1 LIR motif bound to GABARAP
4DDP 1.55 Å, crystal structure of Beclin 1 evolutionarily conserved domain(ECD)
6HOK 1.61 Å, Structure of Beclin1 LIR (S96E) motif bound to GABARAP
5VAU 1.75 Å, Bcl-2 complex with Beclin 1 BH3 domain
5VAY 1.8 Å, Bcl-2 complex with Beclin 1 T108D BH3 domain
5VAX 2.0 Å, Bcl-2 complex with Beclin 1 BH3 domain
4MI8 2.1 Å, Crystal structure of the complex of murine gamma-herpesvirus 68 Bcl-2 homolog M11 and a…
6DCO 2.2 Å, Bcl-xL complex with Beclin 1 BH3 domain T108D
6DCN 2.44 Å, Bcl-xL complex with Beclin 1 BH3 domain T108pThr
2P1L 2.5 Å, Structure of the Bcl-XL:Beclin 1 complex

Browse structure collections

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