5FHX: Codv

Crystal structure of codv in complex with IL4 at 2.55 ang. Resolution. Determined by X-ray diffraction at 2.55 Å resolution. Released 30 Mar 2016.

Method: X-ray diffraction
Resolution: 2.55 Å
Organism: Homo sapiens
Chains: 3
Atoms: 6,263
Mol. weight: 88.03 kDa
Ligands: PO4
Released: 30 Mar 2016

Explore 5FHX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5FHX contains 25 α-helices and 74 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	7-14	8
α-helix	18-20	3
α-helix	23-26	4
β-strand	28-30	3	1
α-helix	41-59	19
α-helix	63-66	4
α-helix	70-94	25
β-strand	106-108	3	1
α-helix	109-126	18

Chain H: 9 helices, 38 β-strands

Element	Residues	Length	Sheet
β-strand	3-6	4	2
α-helix	7-9	3
β-strand	10-12	3	3
β-strand	18-25	8	2
β-strand	34-39	6	3
β-strand	45-51	7	3
β-strand	58-60	3	3
β-strand	68-73	6	2
β-strand	78-83	6	2
α-helix	88-90	3
β-strand	92-102	11	3
β-strand	107-113	7	3
β-strand	117-121	5	3
α-helix	122-124	3
β-strand	127	1	4
β-strand	130-131	2	5
β-strand	135-136	2	6
β-strand	141-147	7	5
β-strand	149	1	4
β-strand	158-163	6	7
β-strand	170-175	6	7
β-strand	181-183	3	7
β-strand	191-196	6	5
β-strand	201-207	7	5
α-helix	211-213	3
β-strand	215-222	8	7
β-strand	229-232	4	7
β-strand	236-238	3	7
β-strand	239-240	2	6
α-helix	243-245	3
β-strand	248	1	8
β-strand	251-255	5	9
α-helix	256-258	3
β-strand	266-276	11	9
β-strand	277	1	8
β-strand	281-285	5	10
α-helix	286-288	3
β-strand	290	1	10
β-strand	294-296	3	9
α-helix	297-299	3
β-strand	300-301	2	9
β-strand	307-316	10	9
β-strand	320	1	11
β-strand	323	1	11
β-strand	326-331	6	10
α-helix	332-334	3
β-strand	336-341	6	10

Chain L: 9 helices, 34 β-strands

Element	Residues	Length	Sheet
β-strand	5-7	3	12
β-strand	10-14	5	13
β-strand	19-24	6	12
β-strand	30	1	14
β-strand	35	1	14
β-strand	37-42	6	13
β-strand	49-53	5	13
β-strand	57-58	2	13
β-strand	66-71	6	12
β-strand	74-79	6	12
β-strand	88-94	7	13
β-strand	101-102	2	13
β-strand	106-111	6	13
α-helix	117-121	5
β-strand	122-125	4	15
β-strand	128-131	4	3
β-strand	137-143	7	15
β-strand	151-156	6	3
β-strand	163-167	5	3
β-strand	171-172	2	3
α-helix	173	1
β-strand	180-185	6	15
β-strand	188-193	6	15
α-helix	198-200	3
β-strand	203-208	6	3
α-helix	214	1
β-strand	215-216	2	3
β-strand	220-224	5	3
α-helix	225-226	2
β-strand	234	1	16
α-helix	235-236	2
β-strand	237-241	5	17
α-helix	242-244	3
α-helix	245-250	6
β-strand	252-262	11	17
β-strand	263	1	16
β-strand	268-273	6	18
β-strand	276-277	2	18
β-strand	282-286	5	17
β-strand	296-305	10	17
α-helix	306-311	6
β-strand	314-320	7	18
β-strand	328-333	6	18

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-4	A	protein	124	Homo sapiens	P05112 (AlphaFold model)
antibody fragment heavy-chain	H	protein	345	Homo sapiens
Antibody fragment light chain	L	protein	334	Homo sapiens

Sequence of entity 1 (A), FASTA

>5FHX_1 Interleukin-4 (chains A)
TLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRC
LGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYS
KCSS

Sequence of entity 2 (H), FASTA

>5FHX_2 antibody fragment heavy-chain (chains H)
AVQLQQSGPELVKPGASVKISCKASGYSFTSYWIHWIKQRPGQGLEWIGMIDPSDGETRL
NQRFQGRATLTVDESTSTAYMQLRSPTSEDSAVYYCTRLKEYGNYDSFYFDVWGAGTLVT
VSSSEVQLKESGPGLVAPGGSLSITCTVSGFSLTDSSINWVRQPPGKGLEWLGMIWGDGR
IDYADALKSRLSISKDSSKSQVFLEMTSLRTDDTATYYCARDGYFPYAMDFWGQGTSVTV
SSRTSATKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAV
LQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK

Sequence of entity 3 (L), FASTA

>5FHX_3 Antibody fragment light chain (chains L)
DIVLTQSPASLAVSLGQRATISCRASESVDSYGQSYMHWYQQKAGQPPKLLIYLASNLES
GVPARFSGSGSRTDFTLTIDPVQAEDAATYYCQQNAEDSRTFGGGTKLEIKGQPKAAPDI
QMTQSPASLSVSVGDTITLTCHASQNIDVWLSWFQQKPGNIPKLLIYKASNLHTGVPSRF
SGSGSGTGFTLTISSLQPEDIATYYCQQAHSYPFTFGGGTKLEIKTKGPSRTVAAPSVFI
FPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS
TLTLSKADYEKHKVYACEVTHQGLSSPVTMSFNR

Ligands and cofactors

ID	Name	Formula	Copies
PO4	Phosphate ion	O4 P	2

Primary citation

CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications. Steinmetz, A., Vallee, F., Beil, C. et al. MAbs (2016) 8:867-878. DOI 10.1080/19420862.2016.1162932 · PubMed

Other PDB entries of the same protein (UniProt P05112 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2D48 1.65 Å, Crystal structure of the Interleukin-4 variant T13D
2B8X 1.7 Å, Crystal structure of the interleukin-4 variant F82D
2B8U 1.8 Å, Crystal structure of wildtype human Interleukin-4
2B8Y 1.8 Å, Crystal structure of the interleukin-4 variant T13DF82D
2B91 2.0 Å, Crystal structure of the interleukin-4 variant F82DR85A
4YDY 2.0 Å, Crystal structure of darpin 44C12V5 in complex with human il-4
1HZI 2.05 Å, Interleukin-4 mutant E9A
2B90 2.1 Å, Crystal structure of the interleukin-4 variant T13DR85A
1RCB 2.25 Å, Crystal structure of human recombinant interleukin-4 at 2.25 Å resolution
1IAR 2.3 Å, Interleukin-4 / receptor alpha chain complex
2INT 2.35 Å, Crystal structure of recombinant human interleukin-4
2B8Z 2.5 Å, Crystal structure of the interleukin-4 variant R85A

Browse structure collections

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