5HF4: Disks large homolog 4

The third PDZ domain from the synaptic protein PSD-95 (H372A mutant). Determined by X-ray diffraction at 1.75 Å resolution. Released 11 Jan 2017.

Method: X-ray diffraction
Resolution: 1.75 Å
Organism: Rattus norvegicus
Chains: 1
Atoms: 1,158
Mol. weight: 12.76 kDa
Released: 11 Jan 2017

Explore 5HF4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5HF4 contains 5 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	302-304	3
α-helix	306-308	3
β-strand	312-317	6	1
β-strand	325-329	5	1
β-strand	336-341	6	1
α-helix	346-350	5
β-strand	357-362	6	1
β-strand	365-366	2	1
α-helix	372-380	9
β-strand	385-392	8	1
α-helix	394-398	5
β-strand	404-406	3	2
β-strand	412-414	3	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Disks large homolog 4	A	protein	119	Rattus norvegicus	P31016 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5HF4_1 Disks large homolog 4 (chains A)
GSPEFLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKG
DQILSVNGVDLRNASAEQAAIALKNAGQTVTIIAQYKPEEYSRFEANSRVDSSGRIVTD

Primary citation

The third PDZ domain from the synaptic protein PSD-95 (H372A mutant). White, K.I., Raman, A.S., Ranganathan, R. To be published.

Other PDB entries of the same protein (UniProt P31016 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5HEY 1.5 Å, The third PDZ domain from the synaptic protein PSD-95 (G330T mutant) in complex with a…
5MZ7 1.53 Å, Crystal Structure of the third PDZ domain from the synaptic protein PSD-95 with…
1TP5 1.54 Å, Crystal structure of PDZ3 domain of PSD-95 protein complexed with a peptide ligand KKETWV
5HFD 1.6 Å, The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant)
5HFB 1.62 Å, The third PDZ domain from the synaptic protein PSD-95 (H372A mutant) in complex with a…
5HEB 1.65 Å, The third PDZ domain from the synaptic protein PSD-95 in complex with a C-terminal…
5HED 1.7 Å, The third PDZ domain from the synaptic protein PSD-95 in complex with a mutant…
5HF1 1.75 Å, The third PDZ domain from the synaptic protein PSD-95 (G330T mutant) in complex with a…
5HFF 1.75 Å, The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant) in…
1KJW 1.8 Å, SH3-Guanylate Kinase Module from PSD-95
5HFE 1.8 Å, The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant) in…
7CQF 1.8 Å, Crystal structure of PSD-95 PDZ3 fused with ADAM22 C-terminal peptide

Browse structure collections

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