Human placental aromatase cytochrome P450 (CYP19A1): androstenedione complex #3. Determined by X-ray diffraction at 3.1 Å resolution. Released 26 Apr 2017.
Explore 5JL7 in 3D Show helices and sheets RCSB PDB PDBe
5JL7 contains 22 α-helices and 12 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 46-48 | 3 | |
| α-helix | 57-68 | 12 | |
| α-helix | 70-80 | 11 | |
| β-strand | 84-88 | 5 | 1 |
| β-strand | 93-97 | 5 | 1 |
| α-helix | 100-108 | 9 | |
| α-helix | 110-112 | 3 | |
| α-helix | 119-125 | 7 | |
| α-helix | 138-151 | 14 | |
| α-helix | 155-173 | 19 | |
| α-helix | 175-177 | 3 | |
| β-strand | 179 | 1 | 2 |
| β-strand | 184-185 | 2 | 2 |
| α-helix | 187-203 | 17 | |
| α-helix | 210-227 | 18 | |
| α-helix | 233-236 | 4 | |
| α-helix | 242-267 | 26 | |
| α-helix | 278-287 | 10 | |
| α-helix | 293-323 | 31 | |
| α-helix | 326-339 | 14 | |
| α-helix | 347-352 | 6 | |
| α-helix | 354-366 | 13 | |
| β-strand | 373-376 | 4 | 1 |
| β-strand | 381-383 | 3 | 3 |
| β-strand | 386-388 | 3 | 3 |
| β-strand | 393-396 | 4 | 1 |
| α-helix | 398-404 | 7 | |
| α-helix | 415-418 | 4 | |
| α-helix | 433-435 | 3 | |
| α-helix | 440-457 | 18 | |
| β-strand | 458-462 | 5 | 2 |
| β-strand | 473-475 | 3 | 4 |
| β-strand | 479-481 | 3 | 4 |
| β-strand | 490-494 | 5 | 2 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Aromatase | A | protein | 503 | Homo sapiens | P11511 (AlphaFold model) |
>5JL7_1 Aromatase (chains A) MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH PDETKNMLEMIFTPRNSDRCLEH
| ID | Name | Formula | Copies |
|---|---|---|---|
| ASD | 4-androstene-3-17-dione | C19 H26 O2 | 1 |
| HEM | Protoporphyrin IX containing FE | C34 H32 Fe N4 O4 | 1 |
Testosterone complex and non-steroidal ligands of human aromatase. Ghosh, D., Egbuta, C., Lo, J. J Steroid Biochem Mol Biol (2018). DOI 10.1016/j.jsbmb.2018.02.009 · PubMed
Other PDB entries of the same protein (UniProt P11511 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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