5KO0: HIAPPWT
Human Islet Amyloid Polypeptide Segment 15-FLVHSSNNFGA-25 Determined by MicroED. Determined by electron crystallography at 1.4 Å resolution. Released 21 Dec 2016.
- Method
- Electron crystallography
- Resolution
- 1.4 Å
- Organism
- Homo sapiens
- Chains
- 2
- Atoms
- 179
- Mol. weight
- 2.44 kDa
- Ligands
- SCN
- Released
- 21 Dec 2016
Explore 5KO0 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
5KO0 contains 0 α-helices and 2 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains A and B: 0 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| β-strand | 16-24 | 9 | 1 |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| hIAPP(15-25)WT | A, B | protein | 11 | Homo sapiens | P10997 (AlphaFold model) |
Sequence of entity 1 (A, B), FASTA
>5KO0_1 hIAPP(15-25)WT (chains A, B)
FLVHSSNNFGA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| SCN | Thiocyanate ion | C N S | 1 |
Primary citation
Atomic structures of fibrillar segments of hIAPP suggest tightly mated beta-sheets are important for cytotoxicity. Krotee, P., Rodriguez, J.A., Sawaya, M.R. et al. Elife (2017) 6. DOI 10.7554/eLife.19273 · PubMed
Other PDB entries of the same protein (UniProt P10997 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8YG2 1.25 Å, Crystal structure of amyloidogenic peptide Piv-NFGAIL-NH2 from Islet Amyloid Polypeptide
- 3FPO 1.5 Å, HSSNNF segment from Islet Amyloid Polypeptide (IAPP or Amylin)
- 3FTK 1.5 Å, NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), hydrated crystal form
- 3FTL 1.6 Å, NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form
- 3FTR 1.61 Å, Structure of an amyloid forming peptide SSTNVG from IAPP (alternate polymorph)
- 3DG1 1.66 Å, Segment SSTNVG derived from IAPP
- 3G7W 1.75 Å, Islet Amyloid Polypeptide (IAPP or Amylin) Residues 1 to 22 fused to Maltose Binding…
- 3FTH 1.84 Å, NFLVHSS segment from Islet Amyloid Polypeptide (IAPP or Amylin)
- 3FR1 1.85 Å, NFLVHS segment from Islet Amyloid Polypeptide (IAPP or Amylin)
- 3G7V 1.86 Å, Islet Amyloid Polypeptide (IAPP or Amylin) fused to Maltose Binding Protein
- 9CC5 1.87 Å, De novo design of high-affinity protein binders to bio active peptide Amylin
- 5KNZ 1.9 Å, Human Islet Amyloid Polypeptide Segment 19-SGNNFGAILSS-29 with Early Onset S20G Mutation…
Browse structure collections
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