5UI0: Fibroblast growth factor receptor 2

Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring an E565A/K659M Double Gain-of-Function Mutation. Determined by X-ray diffraction at 2.05 Å resolution. Released 22 Feb 2017.

Method: X-ray diffraction
Resolution: 2.05 Å
Organism: Homo sapiens
Chains: 2
Atoms: 5,150
Mol. weight: 75.09 kDa
Ligands: FLC, ACP
Released: 22 Feb 2017

Explore 5UI0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5UI0 contains 41 α-helices and 32 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 20 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	468-470	3
β-strand	475	1	1
α-helix	478-480	3
β-strand	481-489	9	1
β-strand	494-501	8	1
β-strand	511-518	8	1
β-strand	524	1	2
α-helix	525-541	17
β-strand	547	1	3
α-helix	548-549	2
β-strand	550-554	5	1
β-strand	561-565	5	1
β-strand	571	1	3
α-helix	572-577	6
α-helix	594-596	3
α-helix	597-599	3
α-helix	600-619	20
β-strand	622-623	2	4
α-helix	629-631	3
β-strand	632-634	3	3
β-strand	640-642	3	3
β-strand	649-650	2	4
β-strand	657-658	2	5
α-helix	659	1
β-strand	666	1	6
α-helix	667-669	3
α-helix	672-677	6
β-strand	679-680	2	5
α-helix	682-697	16
α-helix	701-702	2
α-helix	709-717	9
α-helix	722-725	4
α-helix	730-739	10
α-helix	744-746	3
α-helix	748-749	2
α-helix	750-765	16

Chain B: 21 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	466-470	5
α-helix	472-474	3
β-strand	475	1	7
α-helix	478-480	3
β-strand	481-489	9	7
β-strand	494-501	8	7
β-strand	511-518	8	7
β-strand	524	1	6
α-helix	525-541	17
β-strand	547	1	8
α-helix	548-549	2
β-strand	550-554	5	7
β-strand	561-565	5	7
β-strand	571	1	8
α-helix	572-577	6
α-helix	581	1
α-helix	590-594	5
α-helix	600-619	20
β-strand	622-623	2	9
α-helix	629-631	3
β-strand	632-634	3	8
β-strand	640-642	3	8
β-strand	649-650	2	9
β-strand	657-658	2	10
α-helix	659	1
β-strand	666	1	2
α-helix	667-669	3
α-helix	672-677	6
β-strand	679-680	2	10
α-helix	682-697	16
α-helix	701-702	2
α-helix	709-717	9
α-helix	722-725	4
α-helix	730-739	10
α-helix	744-746	3
α-helix	748-749	2
α-helix	750-764	15

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Fibroblast growth factor receptor 2	A, B	protein	324	Homo sapiens	P21802 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>5UI0_1 Fibroblast growth factor receptor 2 (chains A, B)
MGSSHHHHHHSQDPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGID
KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV
AYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH
RDLAARNVLVTENNVMKIADFGLARDINNIDYYKMTTNGRLPVKWMAPEALFDRVYTHQS
DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP
SQRPTFKQLVEDLDRILTLTTNEE

Ligands and cofactors

ID	Name	Formula	Copies
FLC	Citrate anion	C6 H5 O7	2
ACP	Phosphomethylphosphonic acid adenylate ester	C11 H18 N5 O12 P3	1

Water and common crystallization additives (SO4) are not listed.

Primary citation

Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. Chen, H., Marsiglia, W.M., Cho, M.K. et al. Elife (2017) 6. DOI 10.7554/eLife.21137 · PubMed

Other PDB entries of the same protein (UniProt P21802 (AlphaFold model), which also has an AlphaFold model), best resolution first:

10OU 1.77 Å, FGFR2 mutant D650V with compound 12
2PVF 1.8 Å, Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase…
3B2T 1.8 Å, Structure of phosphotransferase
4J99 1.85 Å, Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function…
10OO 1.85 Å, FGFR2 mutant D650V with compound 4 (AZD3463)
5UGL 1.86 Å, Crystal Structure of FGF Receptor 2 Tyrosine Kinase Domain Harboring the D650V…
3CAF 1.96 Å, Crystal Structure of hFGFR2 D2 Domain
10OQ 1.98 Å, FGFR2 mutant D650V with compound 6
9U7S 1.99 Å, FGFR2 kinase domain with a macrocyclic compound 8r
3CLY 2.0 Å, Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in…
8W3D 2.04 Å, TAS-120 covalent structure with FGFR2 molecular brake mutant
3OJM 2.1 Å, Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert…

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