5XBK: Human Importin4

Crystal structure of human Importin4. Determined by X-ray diffraction at 3.22 Å resolution. Released 14 Feb 2018.

Method
X-ray diffraction
Resolution
3.22 Å
Organisms
Homo sapiens, Xenopus laevis
Chains
5
Atoms
11,162
Mol. weight
181.29 kDa
Released
14 Feb 2018

Explore 5XBK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5XBK contains 105 α-helices and 4 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 25 helices, 2 β-strands

ElementResiduesLengthSheet
α-helix696-70611
α-helix711-73424
α-helix738-76023
α-helix765-78218
α-helix783-7864
α-helix792-80413
α-helix828-84619
α-helix852-86413
β-strand86812
β-strand87012
α-helix872-88918
α-helix890-8967
α-helix897-90711
α-helix914-92916
α-helix933-9364
α-helix939-94911
α-helix955-96915
α-helix981-9877
α-helix9891
α-helix9911
α-helix995-9973
α-helix998-101013
α-helix1013-10153
α-helix1020-103011
α-helix1038-105316
α-helix1056-106510
α-helix1070-10778
Chain B: 28 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix695-7028
α-helix703-7075
α-helix711-73222
α-helix739-76123
α-helix765-78117
α-helix784-7874
α-helix792-80413
α-helix828-8369
α-helix839-8468
α-helix852-86312
α-helix864-8663
α-helix872-88918
α-helix890-8967
α-helix897-90711
α-helix913-92917
α-helix931-9355
α-helix938-94912
α-helix955-97117
α-helix976-9783
α-helix979-98810
α-helix9891
α-helix9911
α-helix998-101114
α-helix1017-10193
α-helix1020-103011
α-helix1038-105316
α-helix1056-10638
α-helix1070-10723
Chain C: 26 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix696-7038
α-helix704-7063
α-helix711-73222
α-helix738-76023
α-helix765-78117
α-helix783-7864
α-helix793-80513
α-helix826-83611
α-helix839-8468
α-helix852-86413
α-helix872-88918
α-helix890-8945
α-helix897-90711
α-helix913-92917
α-helix938-9458
α-helix948-9514
α-helix955-97117
α-helix979-9879
α-helix995-9973
α-helix998-101114
α-helix1013-10153
α-helix1017-10193
α-helix1020-102910
α-helix1038-105114
α-helix1056-10627
α-helix1069-10757
Chain D: 26 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix696-7049
α-helix705-7073
α-helix711-72919
α-helix731-7344
α-helix741-76121
α-helix765-78117
α-helix792-80413
α-helix827-84620
α-helix852-86413
β-strand86811
β-strand87011
α-helix872-88918
α-helix890-8967
α-helix897-90711
α-helix913-92816
α-helix935-9373
α-helix938-95114
α-helix955-97117
α-helix979-9879
α-helix9891
α-helix9911
α-helix995-9973
α-helix998-101013
α-helix1013-10175
α-helix1020-103011
α-helix1038-105215
α-helix1056-10627
α-helix1074-10763

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin-4A, B, C, Dprotein416Homo sapiensQ8TEX9 (AlphaFold model)
histone H3Eprotein18Xenopus laevisP84233 (AlphaFold model)
Sequence of entity 1 (A, B, C, D), FASTA
>5XBK_1 Importin-4 (chains A, B, C, D)
GSAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEALGQFC
CALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLRSCGTL
TLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAA
AGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLPVLL
STAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDNICGAL
ARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVAPELLR
ICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGLS
Sequence of entity 2 (E), FASTA
>5XBK_2 histone H3 (chains E)
ARTKQTARKSTGGKAPRK

Primary citation

Integrative Structural Investigation on the Architecture of Human Importin4_Histone H3/H4_Asf1a Complex and Its Histone H3 Tail Binding. Yoon, J., Kim, S.J., An, S. et al. J Mol Biol (2018) 430:822-841. DOI 10.1016/j.jmb.2018.01.015 · PubMed

Other PDB entries of the same protein (UniProt Q8TEX9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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