5XW5: Budding yeast Cdc14p

Crystal structure of budding yeast Cdc14p (C283S) bound to a Swi6p phosphopeptide. Determined by X-ray diffraction at 1.85 Å resolution. Released 9 Aug 2017.

Method
X-ray diffraction
Resolution
1.85 Å
Organisms
Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae
Chains
3
Atoms
6,588
Mol. weight
96.59 kDa
Released
9 Aug 2017

Explore 5XW5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5XW5 contains 44 α-helices and 28 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 22 helices, 15 β-strands

ElementResiduesLengthSheet
β-strand10-1451
β-strand18-2251
α-helix27-293
β-strand33-3641
α-helix56-7015
α-helix73-753
β-strand79-8461
α-helix88-10518
α-helix110-1145
α-helix115-1173
α-helix123-1264
β-strand12712
α-helix134-1352
β-strand13912
α-helix141-15313
α-helix164-1707
α-helix173-1753
β-strand178-18253
β-strand185-18953
α-helix190-1912
α-helix209-22012
β-strand223-22863
α-helix237-2404
β-strand245-24843
α-helix256-2583
α-helix259-27416
β-strand278-28363
α-helix289-30214
α-helix306-31611
α-helix324-34219
β-strand343-34534
β-strand35015
α-helix351-3533
β-strand35615
α-helix357-3582
β-strand359-36134
α-helix362-3676
Chain B: 21 helices, 13 β-strands
ElementResiduesLengthSheet
β-strand10-1456
β-strand18-2256
α-helix27-293
β-strand33-3646
α-helix56-7116
α-helix73-753
β-strand79-8466
α-helix88-10518
α-helix110-1145
α-helix115-1173
α-helix123-1264
β-strand12717
α-helix134-1352
β-strand13917
α-helix141-15313
α-helix164-1707
α-helix173-1753
β-strand178-18038
β-strand185-18958
α-helix190-1912
α-helix209-22012
β-strand223-22868
α-helix237-2404
β-strand245-24848
α-helix259-27416
β-strand278-28368
α-helix288-30215
α-helix306-31611
α-helix324-34219
β-strand343-34539
α-helix351-3533
α-helix357-3582
β-strand359-36139
α-helix362-3676
Chain C: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix160-1634

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Tyrosine-protein phosphatase CDC14A, Bprotein415Saccharomyces cerevisiae (strain ATCC 204508 / S288c)Q00684 (AlphaFold model)
Regulatory protein SWI6Cprotein10Saccharomyces cerevisiaeP09959 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>5XW5_1 Tyrosine-protein phosphatase CDC14 (chains A, B)
MGSSHHHHHHSQDPNSSSARLQVDKLDYDIPTTENLYFQGSMRRSVYLDNTIEFLRGRVY
LGAYDYTPEDTDELVFFTVEDAIFYNSFHLDFGPMNIGHLYRFAVIFHEILNDPENANKA
VVFYSSASTRQRANAACMLCCYMILVQAWTPHQVLQPLAQVDPPFMPFRDAGYSNADFEI
TIQDVVYGVWRAKEKGLIDLHSFNLESYEKYEHVEFGDFNVLTPDFIAFASPQEDHPKGY
LATKSSHLNQPFKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDL
SIVKNFVGAAETIIKRGGKIAVHSKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPG
MVVGPQQHWLYLHQNDFREWKYTTRISLKPSEAIGGLYPLISLEEYRLQKKKLKD
Sequence of entity 2 (C), FASTA
>5XW5_2 Regulatory protein SWI6 (chains C)
HRELGSPLKK

Primary citation

Structure and dimerization of the catalytic domain of the protein phosphatase Cdc14p, a key regulator of mitotic exit in Saccharomyces cerevisiae. Kobayashi, J., Matsuura, Y. Protein Sci (2017) 26:2105-2112. DOI 10.1002/pro.3244 · PubMed

Other PDB entries of the same protein (UniProt Q00684 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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