6BZ9: Human caspase-1

Crystal structure of human caspase-1 in complex with Ac-FLTD-CMK. Determined by X-ray diffraction at 1.8 Å resolution. Released 13 Jun 2018.

Method: X-ray diffraction
Resolution: 1.8 Å
Organism: Homo sapiens
Chains: 3
Atoms: 2,249
Mol. weight: 30.89 kDa
Released: 13 Jun 2018

Explore 6BZ9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6BZ9 contains 11 α-helices and 16 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 9 β-strands

Element	Residues	Length	Sheet
α-helix	134-135	2
α-helix	138-147	10
α-helix	149-151	3
β-strand	152	1	1
β-strand	164-169	6	2
α-helix	182-195	14
β-strand	199-204	6	2
α-helix	208-219	12
α-helix	222-226	5
β-strand	230-235	6	2
β-strand	238	1	3
β-strand	243-244	2	3
α-helix	245	1
β-strand	255-256	2	3
α-helix	258-265	8
α-helix	271-273	3
β-strand	278-283	6	2
β-strand	289	1	4

Chain B: 2 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	327-331	5	2
β-strand	337	1	4
β-strand	340-342	3	5
β-strand	346-347	2	5
α-helix	348-360	13
α-helix	366-376	11
β-strand	388-390	3	2
β-strand	397	1	1

Chain C: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	3-4	2	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Caspase-1	A	protein	178	Homo sapiens	P29466 (AlphaFold model)
Caspase-1	B	protein	88	Homo sapiens	P29466 (AlphaFold model)
Ac-fltd-cmk	C	protein	6	Homo sapiens

Sequence of entity 1 (A), FASTA

>6BZ9_1 Caspase-1 (chains A)
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRR
TGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGI
REGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

Sequence of entity 2 (B), FASTA

>6BZ9_2 Caspase-1 (chains B)
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFS
FEQPDGRAQMPTTERVTLTRCFYLFPGH

Sequence of entity 3 (C), FASTA

>6BZ9_3 Ac-FLTD-CMK (chains C)
XFLTDX

Primary citation

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Yang, J., Liu, Z., Wang, C. et al. Proc Natl Acad Sci U S A (2018) 115:6792-6797. DOI 10.1073/pnas.1800562115 · PubMed

Other PDB entries of the same protein (UniProt P29466 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8WRA 1.45 Å, The Crystal Structure of CASP1 from Biortus
1SC3 1.8 Å, Crystal structure of the human caspase-1 C285A mutant in complex with malonate
2H54 1.8 Å, Crystal structure of human caspase-1 (Thr388->Ala) in complex with…
2HBQ 1.8 Å, Crystal structure of wildtype human caspase-1 in complex with…
3D6M 1.8 Å, Crystal structure of human caspase-1 with a naturally-occurring Lys319->Arg substitution…
6F6R 1.8 Å, Crystal structure of human Caspase-1 with N-{3-[1-((S)-2-Hydroxy-5-oxo-tetrahydro-furan-3…
1RWX 1.85 Å, Crystal structure of human caspase-1 in complex with 4-oxo-3-{6-[4-(quinoxalin-2-yloxy)-b…
2H4Y 1.9 Å, Crystal structure of human caspase-1 (Arg286->Lys) in complex with…
2HBZ 1.9 Å, Crystal structure of human caspase-1 (Arg286->Ala, Glu390->Ala) in complex with…
3D6F 1.9 Å, Crystal structure of human caspase-1 with a naturally-occurring Arg240->Gln substitution…
6PZP 1.94 Å, Crystal structure of caspase-1 in complex with VX-765
1RWN 2.0 Å, Crystal structure of human caspase-1 in complex with 3-{2-ethyl-6-[4-(quinoxalin-2-ylamin…

Browse structure collections

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