6EHM: Nucleoprotein

Model of the Ebola virus nucleocapsid subunit from recombinant virus-like particles. Determined by electron microscopy at 7.3 Å resolution. Released 8 Nov 2017.

Method

Electron microscopy

Resolution

7.3 Å

Organism

Zaire ebolavirus (strain Mayinga-76)

Chains

4

Atoms

1,224

Mol. weight

223.28 kDa

Released

8 Nov 2017

Explore 6EHM in 3D Show helices and sheets RCSB PDB PDBe

Molecules and chains

>6EHM_1 Nucleoprotein (chains A, B)
MDSRPQKIWMAPSLTESDMDYHKILTAGLSVQQGIVRQRVIPVYQVNNLEEICQLIIQAF
EAGVDFQESADSFLLMLCLHHAYQGDYKLFLESGAVKYLEGHGFRFEVKKRDGVKRLEEL
LPAVSSGKNIKRTLAAMPEEETTEANAGQFLSFASLFLPKLVVGEKACLEKVQRQIQVHA
EQGLIQYPTAWQSVGHMMVIFRLMRTNFLIKFLLIHQGMHMVAGHDANDAVISNSVAQAR
FSGLLIVKTVLDHILQKTERGVRLHPLARTAKVKNEVNSFKAALSSLAKHGEYAPFARLL
NLSGVNNLEHGLFPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAATEAEKQLQQYAES
RELDHLGLDDQEKKILMNFHQKKNEISFQQTNAMVTLRKERLAKLTEAITAASLPKTSGH
YDDDDDIPFPGPINDDDNPGHQDDDPTDSQDTTIPDVVVDPDDGSYGEYQSYSENGMNAP
DDLVLFDLDEDDEDTKPVPNRSTKGGQQKNSQKGQHIEGRQTQSRPIQNVPGPHRTIHHA
SAPLTDNDRRNEPSGSTSPRMLTPINEEADPLDDADDETSSLPPLESDDEEQDRDGTSNR
TPTVAPPAPVYRDHSEKKELPQDEQQDQDHTQEARNQDSDNTQSEHSFEEMYRHILRSQG
PFDAVLYYHMMKDEPVVFSTSDGKEYTYPDSLEEEYPPWLTEKEAMNEENRFVTLDGQQF
YWPVMNHKNKFMAILQHHQ

>6EHM_2 Membrane-associated protein VP24 (chains C, D)
MAKATGRYNLISPKKDLEKGVVLSDLCNFLVSQTIQGWKVYWAGIEFDVTHKGMALLHRL
KTNDFAPAWSMTRNLFPHLFQNPNSTIESPLWALRVILAAGIQDQLIDQSLIEPLAGALG
LISDWLLTTNTNHFNMRTQRVKEQLSLKMLSLIRSNILKFINKLDALHVVNYNGLLSSIE
IGTQNHTIIITRTNMGFLVELQEPDKSAMNRMKPGPAKFSLLHESTLKAFTQGSSTRMQS
LILEFNSSLAI

Primary citation

Structure and assembly of the Ebola virus nucleocapsid. Wan, W., Kolesnikova, L., Clarke, M. et al. Nature (2017) 551:394-397. DOI 10.1038/nature24490 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P18272 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 4QB0 1.75 Å, The crystal structure of the C-terminal domain of Ebola (Zaire) nucleoprotein
• 4Z9P 1.79 Å, Crystal structure of Ebola virus nucleoprotein core domain at 1.8A resolution
• 4QAZ 1.98 Å, The crystal structure of the C-terminal domain of Ebola (Zaire) nucleoprotein
• 5T3T 2.2 Å, Ebola virus VP30 CTD bound to nucleoprotein
• 4ZTA 2.4 Å, Ebola virus nucleoprotein bound to VP35 chaperoning peptide I212121
• 4ZTI 2.4 Å, Ebola virus nucleoprotein bound to VP35 chaperoning peptide P212121
• 4ZTG 2.8 Å, Ebola virus nucleoprotein bound to VP35 chaperoning peptide P22121
• 6NUT 3.1 Å, Ebola virus nucleoprotein - RNA complex
• 5Z9W 3.6 Å, Ebola virus nucleoprotein-RNA complex
• 4YPI 3.71 Å, Structure of Ebola virus nucleoprotein N-terminal fragment bound to a peptide derived…
• 8Y9J 4.6 Å, Structure of the Ebola virus nucleocapsid subunit
• 6C54 5.8 Å, Ebola nucleoprotein nucleocapsid-like assembly and the asymmetric unit

Browse structure collections

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