6EXV: DNA-directed RNA polymerase II subunit RPB1

Structure of mammalian RNA polymerase II elongation complex inhibited by Alpha-amanitin. Determined by electron microscopy at 3.6 Å resolution. Released 21 Mar 2018.

Method: Electron microscopy
Resolution: 3.6 Å
Organisms: Sus scrofa, Sus Scrofa, Amanita phalloides
Chains: 16
Atoms: 32,717
Mol. weight: 550.93 kDa
Ligands: ZN, MG
Released: 21 Mar 2018

Explore 6EXV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6EXV contains 149 α-helices and 248 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 70 helices, 79 β-strands

Element	Residues	Length	Sheet
β-strand	15-16	2	1
β-strand	22	1	2
β-strand	25	1	3
α-helix	26-27	2
α-helix	28-34	7
β-strand	47	1	4
β-strand	52	1	4
α-helix	53	1
β-strand	86-95	10	5
α-helix	100-109	10
β-strand	110	1	6
β-strand	117	1	6
α-helix	124-131	8
α-helix	137-147	11
β-strand	153	1	7
β-strand	187	1	7
β-strand	190	1	8
β-strand	193-194	2	9
β-strand	197-200	4	9
β-strand	201	1	8
β-strand	214-216	3	9
α-helix	218-225	8
α-helix	232-236	5
α-helix	245-248	4
β-strand	249-255	7	5
α-helix	262-263	2
β-strand	264-266	3	10
β-strand	270-272	3	10
α-helix	277-295	19
α-helix	304-315	12
α-helix	326-328	3
β-strand	329-331	3	11
β-strand	334-335	2	11
α-helix	336	1
α-helix	339-342	4
β-strand	346	1	12
β-strand	351	1	12
β-strand	358-359	2	13
β-strand	362-366	5	14
β-strand	367-369	3	15
β-strand	378-380	3	15
β-strand	389-393	5	16
α-helix	399-407	9
β-strand	416-420	5	16
β-strand	426-428	3	16
β-strand	442	1	17
β-strand	444	1	17
β-strand	445-449	5	16
α-helix	450	1
β-strand	455	1	18
β-strand	457-459	3	14
α-helix	466-468	3
β-strand	471	1	19
β-strand	473	1	18
β-strand	474-476	3	15
β-strand	482-484	3	15
α-helix	489-492	4
β-strand	500-504	5	14
α-helix	509-516	8
β-strand	520	1	19
α-helix	522-524	3
β-strand	526	1	20
β-strand	533	1	20
α-helix	540-548	9
α-helix	557-564	8
α-helix	574	1
β-strand	575	1	21
α-helix	576-577	2
β-strand	579-581	3	22
β-strand	585	1	22
α-helix	588-592	5
β-strand	602-603	2	23
β-strand	629-630	2	23
β-strand	635-637	3	23
α-helix	642-645	4
α-helix	652-659	8
α-helix	663-683	21
β-strand	686	1	24
α-helix	690-692	3
α-helix	698-721	24
α-helix	733-747	15
α-helix	750-757	8
α-helix	767-770	4
α-helix	778-785	8
β-strand	789-790	2	25
β-strand	792-793	2	26
β-strand	796-797	2	26
α-helix	798-799	2
β-strand	822-823	2	25
α-helix	833-867	35
β-strand	872-873	2	27
β-strand	879-880	2	27
β-strand	886-888	3	27
α-helix	891-893	3
β-strand	896	1	28
β-strand	902-905	4	29
α-helix	913-919	7
α-helix	929-933	5
β-strand	934	1	30
α-helix	936-942	7
α-helix	946-951	6
α-helix	954-969	16
β-strand	976-979	4	29
α-helix	983-993	11
α-helix	1001	1
β-strand	1002	1	30
α-helix	1006-1018	13
α-helix	1032-1037	6
α-helix	1040-1048	9
α-helix	1052-1053	2
α-helix	1054-1058	5
α-helix	1063-1076	14
β-strand	1080	1	28
α-helix	1081-1082	2
α-helix	1087-1090	4
α-helix	1098-1101	4
α-helix	1121-1127	7
β-strand	1140-1141	2	31
α-helix	1146-1148	3
α-helix	1151-1161	11
β-strand	1164	1	32
α-helix	1166-1169	4
β-strand	1170-1176	7	33
β-strand	1177	1	34
α-helix	1192-1198	7
β-strand	1210	1	34
β-strand	1211-1216	6	33
α-helix	1218-1222	5
α-helix	1228-1234	7
β-strand	1243-1247	5	33
β-strand	1255-1261	7	33
α-helix	1263-1265	3
α-helix	1281-1292	12
β-strand	1299	1	32
β-strand	1307	1	35
β-strand	1310	1	36
β-strand	1319-1322	4	37
β-strand	1328-1331	4	37
β-strand	1335	1	36
β-strand	1336-1337	2	31
β-strand	1338	1	35
α-helix	1343-1347	5
α-helix	1362-1368	7
α-helix	1372-1386	15
α-helix	1395-1405	11
α-helix	1416-1419	4
α-helix	1426-1429	4
α-helix	1435-1445	11
β-strand	1471-1475	5	38

Chain B: 42 helices, 89 β-strands

Element	Residues	Length	Sheet
α-helix	22-36	15
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-60	6
β-strand	83-93	11	39
β-strand	98-99	2	40
β-strand	105-106	2	40
α-helix	107-109	3
α-helix	110-115	6
β-strand	121-133	13	39
β-strand	142-143	2	39
β-strand	147-153	7	39
α-helix	168-173	6
β-strand	187	1	41
β-strand	190	1	41
β-strand	192-193	2	42
α-helix	194-195	2
β-strand	196-200	5	43
α-helix	201	1
β-strand	206-207	2	44
β-strand	219-220	2	44
β-strand	222-223	2	45
β-strand	233-234	2	45
β-strand	236	1	46
β-strand	237	1	44
β-strand	239	1	47
α-helix	249-252	4
β-strand	256	1	47
β-strand	257-258	2	48
β-strand	259	1	46
β-strand	267-268	2	48
α-helix	269-274	6
β-strand	275	1	49
β-strand	277	1	49
α-helix	281-287	7
α-helix	295-299	5
α-helix	302-307	6
α-helix	314-322	9
α-helix	333-345	13
α-helix	359-376	18
β-strand	391-394	4	43
α-helix	397-421	25
α-helix	438-449	12
β-strand	453	1	50
β-strand	463	1	50
β-strand	468-469	2	42
α-helix	475-481	7
β-strand	485-486	2	43
α-helix	503-505	3
β-strand	509	1	51
α-helix	517-519	3
β-strand	524	1	43
β-strand	526	1	51
β-strand	531-532	2	52
α-helix	541-546	6
β-strand	551	1	53
α-helix	558-560	3
β-strand	565-569	5	53
β-strand	572-577	6	53
α-helix	580-592	13
β-strand	602-606	5	53
β-strand	611-615	5	53
β-strand	621-626	6	52
β-strand	628	1	54
β-strand	633	1	54
α-helix	637-639	3
α-helix	653-657	5
β-strand	662-666	5	52
α-helix	669-671	3
β-strand	675-676	2	55
α-helix	679-682	4
β-strand	695-696	2	55
α-helix	714-716	3
β-strand	717	1	56
α-helix	719-725	7
β-strand	732	1	57
β-strand	748-751	4	58
β-strand	755	1	59
β-strand	759-760	2	60
β-strand	776-782	7	61
β-strand	783	1	24
β-strand	794-797	4	61
α-helix	798-801	4
β-strand	808-817	10	58
β-strand	827-829	3	62
β-strand	837	1	62
α-helix	845-847	3
β-strand	853	1	63
α-helix	854-855	2
β-strand	859-860	2	58
β-strand	867	1	63
β-strand	869-872	4	62
β-strand	889-891	3	62
β-strand	894	1	63
β-strand	902-911	10	58
β-strand	917-927	11	58
β-strand	934-936	3	64
β-strand	943-944	2	64
β-strand	947-949	3	61
α-helix	951-953	3
β-strand	965-967	3	61
α-helix	969-971	3
β-strand	977	1	56
α-helix	979-993	15
β-strand	997-998	2	60
α-helix	1008-1015	8
β-strand	1025-1026	2	61
β-strand	1029	1	65
β-strand	1036	1	65
β-strand	1041-1048	8	61
β-strand	1049-1050	2	64
β-strand	1051	1	57
β-strand	1067	1	66
β-strand	1074	1	66
β-strand	1076	1	67
β-strand	1083	1	67
β-strand	1084-1085	2	13
α-helix	1092-1095	4
α-helix	1101-1104	4
α-helix	1105-1109	5
β-strand	1115	1	68
β-strand	1118-1119	2	69
β-strand	1125	1	69
β-strand	1127-1129	3	70
β-strand	1134-1136	3	70
β-strand	1146-1147	2	69
β-strand	1148-1149	2	1
β-strand	1150	1	68
α-helix	1153-1163	11
β-strand	1167	1	3
β-strand	1170	1	2

Chain C: 7 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	71
β-strand	18-24	7	71
α-helix	28-37	10
β-strand	44-49	6	72
β-strand	50-51	2	73
β-strand	52-55	4	74
α-helix	61-67	7
β-strand	73	1	75
α-helix	83-84	2
β-strand	101-102	2	76
β-strand	103-106	4	74
β-strand	113-115	3	77
α-helix	117-119	3
β-strand	121-122	2	76
β-strand	129	1	75
β-strand	151-153	3	77
β-strand	158-161	4	74
β-strand	164-168	5	72
β-strand	182-185	4	71
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-234	6	71
α-helix	244-268	25

Chain D: 6 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	78
β-strand	30-31	2	38
α-helix	34-45	12
α-helix	60-70	11
α-helix	77-89	13
α-helix	94-100	7
α-helix	108-114	7
α-helix	124-137	14

Chain E: 7 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	4-24	21
β-strand	26	1	79
α-helix	30-32	3
α-helix	37-43	7
β-strand	60-63	4	80
β-strand	64	1	79
β-strand	71-75	5	80
β-strand	81-82	2	81
α-helix	85-97	13
β-strand	101-106	6	80
β-strand	109-110	2	81
α-helix	112-119	8
β-strand	127-131	5	80
α-helix	139-141	3
β-strand	147-150	4	82
α-helix	153-161	9
β-strand	172-173	2	82
β-strand	190-195	6	82
β-strand	203-209	7	82

Chain F: 4 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56-57	2	83
α-helix	58	1
α-helix	59-74	16
α-helix	77-79	3
α-helix	89-97	9
β-strand	104-109	6	38
β-strand	115-119	5	38
β-strand	124-125	2	83

Chain G: 1 helix, 17 β-strands

Element	Residues	Length	Sheet
β-strand	3-13	11	38
α-helix	25-32	8
β-strand	38	1	84
β-strand	44	1	84
β-strand	48-54	7	38
β-strand	58-59	2	38
β-strand	66-75	10	38
β-strand	81	1	78
β-strand	85-87	3	85
β-strand	88-92	5	86
β-strand	97-101	5	86
β-strand	104-108	5	86
β-strand	119	1	87
β-strand	128	1	87
β-strand	143-145	3	85
β-strand	152	1	88
β-strand	157	1	88
β-strand	160-161	2	86

Chain H: 0 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	4-14	11	22
β-strand	25-33	9	22
β-strand	38-44	7	22
β-strand	55-61	7	22
β-strand	74	1	21
β-strand	90-100	11	22
β-strand	113-118	6	22
β-strand	121-126	6	22
β-strand	140-145	6	22
β-strand	147	1	22

4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase II subunit RPB1	A	protein	1970	Sus scrofa	A0A8D1DPV6
DNA-directed RNA polymerase II subunit RPB2	B	protein	1167	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	I3LCH3 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	D	protein	142	Sus scrofa	A0A287ADR4 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	210	Sus scrofa	I3LSI7
DNA-directed RNA polymerases I, II, and III subunit RPABC1	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus Scrofa	A0A8W4F9W9
DNA-directed RNA polymerases I, II, and III subunit RPABC4	K	protein	117	Sus scrofa	F1RKE4
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	58	Sus scrofa	A0A4X1TRS6

4 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>6EXV_1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 2 (B), FASTA

>6EXV_2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (chains B)
MQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDL
QAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVD
ITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYFII
NGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQGA
KKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEMVKPSLDE
AFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGY
MVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGK
DFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLSHLRRLNS
PIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEE
WSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVSMIRDI
REREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDT
LEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSA
MGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTG
YNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGMRHAIYDK
LDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSETGIVDQV
MVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIII
NPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEV
LYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFG
EMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQIS
LVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>6EXV_3 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>6EXV_4 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 5 (E), FASTA

>6EXV_5 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>6EXV_6 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>6EXV_7 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>6EXV_8 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>6EXV_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>6EXV_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>6EXV_11 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4 (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>6EXV_12 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	8
MG	Magnesium ion	Mg	1

Primary citation

Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by alpha-amanitin. Liu, X., Farnung, L., Wigge, C. et al. J Biol Chem (2018) 293:7189-7194. DOI 10.1074/jbc.RA118.002545 · PubMed

Other PDB entries of the same protein (UniProt A0A8D1DPV6), best resolution first:

9HVQ 2.0 Å, Structure of the transcribing Pol II-DSIF-PAF-SPT6-RECQL5 complex
7NVU 2.5 Å, RNA polymerase II core pre-initiation complex with open promoter DNA
8QEP 2.5 Å, RNA polymerase II bound to Alu RNA right arm
8B3D 2.6 Å, Structure of the Pol II-TCR-ELOF1 complex.
7OOB 2.7 Å, Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2)
8UHG 2.7 Å, Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated
8UI0 2.7 Å, Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated
8WAV 2.72 Å, De novo transcribing complex 12 (TC12), the early elongation complex with Pol II…
8WAX 2.75 Å, De novo transcribing complex 14 (TC14), the early elongation complex with Pol II…
8WAZ 2.76 Å, De novo transcribing complex 16 (TC16), the early elongation complex with Pol II…
7F4G 2.78 Å, Structure of RPAP2-bound RNA polymerase II
8WAU 2.78 Å, De novo transcribing complex 11 (TC11), the early elongation complex with Pol II…

Browse structure collections

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