6GMH: RPB1

Name: PDB 6GMH: Structure of activated transcription complex Pol II-DSIF-PAF-SPT6
Published: 2018-08-22
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Determined by electron microscopy at 3.1 Å resolution. Released 22 Aug 2018.

Method: Electron microscopy
Resolution: 3.1 Å
Organisms: Sus scrofa, Homo sapiens, synthetic construct
Chains: 23
Atoms: 50,239
Mol. weight: 1208.87 kDa
Ligands: MG, ZN
Released: 22 Aug 2018

Explore 6GMH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6GMH contains 291 α-helices and 345 β-strands across 20 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 73 helices, 69 β-strands

Element	Residues	Length	Sheet
β-strand	15-16	2	1
β-strand	20-22	3	2
β-strand	25	1	3
α-helix	28-34	7
β-strand	43	1	4
β-strand	47-49	3	5
β-strand	51-52	2	5
α-helix	53	1
β-strand	56	1	4
β-strand	86-94	9	6
α-helix	100-109	10
α-helix	111	1
α-helix	124-132	9
α-helix	137-149	13
α-helix	189	1
β-strand	190-194	5	7
β-strand	197-201	5	7
β-strand	214-215	2	7
α-helix	218-226	9
α-helix	230-236	7
α-helix	245-247	3
β-strand	250-255	6	6
α-helix	256	1
β-strand	264	1	8
β-strand	272	1	8
α-helix	275-296	22
α-helix	302-318	17
α-helix	326-328	3
β-strand	329	1	9
α-helix	334	1
β-strand	335	1	9
α-helix	336	1
α-helix	339-342	4
α-helix	350-353	4
β-strand	357-358	2	10
β-strand	362-369	8	11
β-strand	377-380	4	11
α-helix	382-385	4
β-strand	389-393	5	12
α-helix	394	1
α-helix	399-408	10
β-strand	416-420	5	12
β-strand	426-428	3	12
β-strand	445-449	5	12
α-helix	450	1
β-strand	455-459	5	11
β-strand	469-476	8	11
β-strand	482-484	3	11
α-helix	489-492	4
β-strand	500-504	5	11
α-helix	509-518	10
β-strand	520	1	11
α-helix	521-524	4
β-strand	526	1	13
β-strand	533	1	13
α-helix	541-548	8
β-strand	554-555	2	14
α-helix	557-564	8
α-helix	574	1
β-strand	575	1	15
α-helix	576-577	2
β-strand	579-581	3	16
β-strand	585	1	16
β-strand	586-587	2	14
α-helix	588-595	8
β-strand	602-603	2	17
α-helix	612-615	4
β-strand	629-630	2	17
β-strand	635-637	3	17
α-helix	642-645	4
α-helix	652-659	8
α-helix	662-683	22
β-strand	686	1	18
α-helix	697-721	25
α-helix	726-728	3
α-helix	733-759	27
α-helix	765-772	8
α-helix	778-785	8
β-strand	789-790	2	19
β-strand	793	1	20
β-strand	796	1	20
β-strand	822-823	2	19
α-helix	833-868	36
β-strand	872-873	2	21
β-strand	879-880	2	21
β-strand	886-888	3	21
α-helix	891-893	3
β-strand	896	1	22
α-helix	898-900	3
β-strand	902-905	4	23
α-helix	914-920	7
α-helix	927-933	7
β-strand	934	1	24
α-helix	936-944	9
α-helix	946-969	24
β-strand	976-979	4	23
α-helix	983-993	11
β-strand	1002	1	24
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1053	3
α-helix	1054-1058	5
α-helix	1062-1077	16
β-strand	1080	1	22
α-helix	1081-1082	2
α-helix	1087-1096	10
α-helix	1098-1100	3
α-helix	1121-1128	8
β-strand	1140-1142	3	25
β-strand	1143	1	26
α-helix	1146-1149	4
α-helix	1151-1161	11
β-strand	1164	1	27
α-helix	1166-1169	4
β-strand	1170-1177	8	28
α-helix	1189-1194	6
β-strand	1210-1216	7	28
α-helix	1218-1224	7
α-helix	1228-1238	11
β-strand	1245-1247	3	28
β-strand	1256-1259	4	28
α-helix	1283-1294	12
β-strand	1299	1	27
β-strand	1310	1	25
β-strand	1319-1320	2	29
β-strand	1330-1331	2	29
β-strand	1335-1337	3	25
β-strand	1352	1	26
α-helix	1362-1368	7
α-helix	1371-1387	17
α-helix	1395-1404	10
β-strand	1408-1409	2	30
α-helix	1416-1419	4
α-helix	1426-1429	4
α-helix	1437-1445	9
β-strand	1448-1449	2	2
α-helix	1454-1457	4
β-strand	1472-1475	4	31
α-helix	1479-1481	3
β-strand	1484	1	32
α-helix	1534-1538	5

Chain B: 48 helices, 75 β-strands

Element	Residues	Length	Sheet
α-helix	22-36	15
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-65	3
β-strand	84	1	33
β-strand	87-93	7	33
β-strand	97-98	2	34
β-strand	106-107	2	34
α-helix	108-109	2
α-helix	110-116	7
β-strand	121-133	13	33
β-strand	139-153	15	33
α-helix	168-173	6
β-strand	185-186	2	35
β-strand	191-193	3	35
β-strand	196-200	5	36
β-strand	206-208	3	37
β-strand	215-223	9	37
β-strand	233-240	8	37
β-strand	256-259	4	37
β-strand	263	1	38
β-strand	267-268	2	37
α-helix	269-276	8
α-helix	282-285	4
α-helix	295-305	11
α-helix	314-323	10
β-strand	325	1	38
α-helix	332-341	10
α-helix	342-346	5
α-helix	358-376	19
α-helix	382-384	3
β-strand	391-394	4	36
α-helix	396-425	30
α-helix	431-434	4
α-helix	437-450	14
β-strand	468-469	2	35
α-helix	470-471	2
α-helix	475-482	8
β-strand	484-486	3	36
α-helix	501-502	2
α-helix	503-505	3
β-strand	523-525	3	36
β-strand	531-534	4	39
α-helix	539-545	7
β-strand	551-552	2	40
β-strand	565-569	5	40
β-strand	572-577	6	40
α-helix	584-591	8
β-strand	602-605	4	40
β-strand	612-615	4	40
β-strand	618-627	10	39
β-strand	628-629	2	41
β-strand	632-633	2	41
α-helix	637-644	8
α-helix	653-658	6
β-strand	662-666	5	39
α-helix	667-671	5
β-strand	675-676	2	39
α-helix	679-682	4
β-strand	695-696	2	39
α-helix	700-703	4
α-helix	707-710	4
α-helix	714-716	3
β-strand	717	1	42
α-helix	719-728	10
β-strand	732	1	43
β-strand	748-751	4	44
β-strand	755	1	45
β-strand	759-760	2	46
β-strand	776-782	7	47
β-strand	783	1	18
β-strand	794-797	4	47
α-helix	798-803	6
β-strand	808-817	10	44
β-strand	827-829	3	48
β-strand	837	1	48
β-strand	853	1	49
α-helix	854-855	2
β-strand	859	1	44
β-strand	865-867	3	49
β-strand	869-872	4	48
β-strand	889-891	3	48
β-strand	894-895	2	49
α-helix	896-897	2
β-strand	903-911	9	44
β-strand	917-927	11	44
β-strand	934-936	3	50
β-strand	943-944	2	50
β-strand	945-949	5	47
β-strand	956	1	51
β-strand	965-967	3	47
α-helix	969-971	3
β-strand	977	1	42
α-helix	978-993	16
α-helix	995-996	2
β-strand	997-998	2	46
α-helix	1008-1015	8
α-helix	1016-1018	3
β-strand	1025-1026	2	47
β-strand	1029	1	51
α-helix	1035	1
β-strand	1036	1	51
α-helix	1037	1
α-helix	1040	1
β-strand	1041-1048	8	47
β-strand	1049-1050	2	50
β-strand	1051	1	43
β-strand	1060-1062	3	11
β-strand	1067	1	52
β-strand	1074	1	52
β-strand	1085-1086	2	10
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1115-1119	5	1
β-strand	1125	1	1
β-strand	1127-1129	3	53
β-strand	1134-1136	3	53
β-strand	1146-1150	5	1
α-helix	1153-1164	12
β-strand	1167	1	3
β-strand	1170-1172	3	2

Chain C: 10 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	54
β-strand	18-24	7	54
α-helix	28-40	13
β-strand	44-55	12	55
α-helix	61-69	9
β-strand	73	1	56
α-helix	78-81	4
β-strand	99-106	8	55
α-helix	112	1
β-strand	113-116	4	57
α-helix	117-119	3
β-strand	121-122	2	55
β-strand	129	1	56
β-strand	149-153	5	57
β-strand	158-168	11	55
α-helix	174-176	3
β-strand	179-185	7	54
α-helix	200-202	3
α-helix	204-205	2
α-helix	218-220	3
β-strand	229-235	7	54
α-helix	241-270	30

Chain D: 8 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	30-31	2	58
α-helix	34-49	16
α-helix	55-58	4
α-helix	59-70	12
α-helix	77-89	13
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-136	13

Chain E: 11 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	4-24	21
β-strand	26-27	2	59
α-helix	30-33	4
α-helix	37-44	8
β-strand	61-64	4	59
β-strand	71-73	3	59
α-helix	88-96	9
β-strand	101-102	2	59
β-strand	103-106	4	60
α-helix	109-111	3
α-helix	112-120	9
β-strand	128-131	4	60
α-helix	133-135	3
α-helix	139-141	3
β-strand	147-150	4	30
α-helix	151-152	2
α-helix	153-163	11
β-strand	172-173	2	30
α-helix	178-183	6
β-strand	190-196	7	30
β-strand	202-209	8	30

Chain F: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	61
α-helix	59-74	16
α-helix	77-78	2
β-strand	79	1	32
α-helix	89-99	11
β-strand	104-109	6	31
β-strand	115-119	5	31
α-helix	120-122	3
β-strand	124	1	61

Chain G: 4 helices, 16 β-strands

Element	Residues	Length	Sheet
β-strand	2	1	31
β-strand	3-4	2	58
β-strand	5-13	9	31
α-helix	15-18	4
α-helix	22-34	13
β-strand	38-39	2	31
β-strand	43-54	12	31
α-helix	55-57	3
β-strand	58-59	2	31
α-helix	60	1
β-strand	66-77	12	31
β-strand	83-92	10	62
β-strand	96-101	6	62
β-strand	104-109	6	62
β-strand	118-120	3	63
β-strand	127-129	3	63
β-strand	136-138	3	63
β-strand	142-153	12	62
β-strand	156-162	7	62
β-strand	170	1	62

Chain H: 1 helix, 14 β-strands

Element	Residues	Length	Sheet
β-strand	4-14	11	64
β-strand	25-32	8	64
β-strand	38-44	7	64
β-strand	55-61	7	64
β-strand	65	1	65
β-strand	74	1	15
β-strand	83	1	65
α-helix	85-87	3
β-strand	90	1	64
β-strand	91-92	2	16
β-strand	93-101	9	64
β-strand	112-118	7	64
β-strand	121-126	6	64
β-strand	140-142	3	64
β-strand	145-147	3	64

12 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
RPB1	A	protein	1970	Sus scrofa	A0A8D1DPV6
DNA-directed RNA polymerase subunit beta	B	protein	1174	Sus scrofa	I3LGP4 (AlphaFold model)
RNA polymerase II subunit C	C	protein	275	Sus scrofa	I3LCH3 (AlphaFold model)
RNA polymerase II subunit D	D	protein	142	Sus scrofa	A0A287ADR4 (AlphaFold model)
RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7
RNA polymerase II subunit F	F	protein	127	Sus scrofa	A0A4X1VEK9
RNA polymerase II subunit G	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
RPB10	J	protein	67	Sus scrofa	A0A8W4F9W9
RPB11	K	protein	117	Sus scrofa	F1RKE4
RPB12	L	protein	58	Sus scrofa	A0A4X1TRS6

11 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>6GMH_1 RPB1 (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 2 (B), FASTA

>6GMH_2 DNA-directed RNA polymerase subunit beta (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>6GMH_3 RNA polymerase II subunit C (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>6GMH_4 RNA polymerase II subunit D (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 5 (E), FASTA

>6GMH_5 RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>6GMH_6 RNA polymerase II subunit F (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>6GMH_7 RNA polymerase II subunit G (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>6GMH_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>6GMH_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>6GMH_10 RPB10 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>6GMH_11 RPB11 (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>6GMH_12 RPB12 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	9

Primary citation

Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Vos, S.M., Farnung, L., Boehning, M. et al. Nature (2018) 560:607-612. DOI 10.1038/s41586-018-0440-4 · PubMed

Other PDB entries of the same protein (UniProt A0A8D1DPV6), best resolution first:

9HVQ 2.0 Å, Structure of the transcribing Pol II-DSIF-PAF-SPT6-RECQL5 complex
7NVU 2.5 Å, RNA polymerase II core pre-initiation complex with open promoter DNA
8QEP 2.5 Å, RNA polymerase II bound to Alu RNA right arm
8B3D 2.6 Å, Structure of the Pol II-TCR-ELOF1 complex.
7OOB 2.7 Å, Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2)
8UHG 2.7 Å, Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated
8UI0 2.7 Å, Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated
8WAV 2.72 Å, De novo transcribing complex 12 (TC12), the early elongation complex with Pol II…
8WAX 2.75 Å, De novo transcribing complex 14 (TC14), the early elongation complex with Pol II…
8WAZ 2.76 Å, De novo transcribing complex 16 (TC16), the early elongation complex with Pol II…
7F4G 2.78 Å, Structure of RPAP2-bound RNA polymerase II
8WAU 2.78 Å, De novo transcribing complex 11 (TC11), the early elongation complex with Pol II…

Browse structure collections

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