6HQ1: Globular domain from human histone H1.0
Solution structure of the globular domain from human histone H1.0. Determined by solution NMR. Released 9 Oct 2019.
- Method
- Solution NMR
- Organism
- Homo sapiens
- Chains
- 1
- Atoms
- 572
- Mol. weight
- 8.16 kDa
- Released
- 9 Oct 2019
Explore 6HQ1 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6HQ1 contains 3 α-helices and 3 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 3 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-16 | 11 | |
| β-strand | 23 | 1 | 1 |
| α-helix | 25-35 | 11 | |
| α-helix | 40-56 | 17 | |
| β-strand | 59-61 | 3 | 1 |
| β-strand | 71-73 | 3 | 1 |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Histone H1.0 | A | protein | 75 | Homo sapiens | P07305 (AlphaFold model) |
Sequence of entity 1 (A), FASTA
>6HQ1_1 Histone H1.0 (chains A)
GDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLK
QTKGVGASGSFRLAK
Primary citation
Micromolar affinity association of an IDP and a folded protein without the involvement of persistent binding sites. Bugge, K., Martinsen, J.H., Fernandes, C.B. et al. To be published.
Other PDB entries of the same protein (UniProt P07305 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7COW 2.86 Å, 353 bp di-nucleosome harboring cohesive DNA termini with linker histone H1.0
- 7K5X 2.93 Å, Cryo-EM structure of a chromatosome containing human linker histone H1.0
- 6LAB 3.2 Å, 169 bp nucleosome, harboring cohesive DNA termini, assembled with linker histone H1.0
- 7XX6 3.39 Å, Crystal Structure of Nucleosome-H1.0 Linker Histone Assembly (sticky-169a DNA fragment)
- 6LA8 3.4 Å, 349 bp di-nucleosome harboring cohesive DNA termini assembled with linker histone H1.0
- 7XVL 3.51 Å, Crystal Structure of Nucleosome-H1.0 Linker Histone Assembly (sticky-169an DNA fragment)
- 30FM 3.6 Å, Structure of histone H1 in an import-chaperone complex with importin beta and importin 7…
- 30HD 3.6 Å, Structure of histone H1 in an import-chaperone complex with importin beta and importin 7…
- 6LA9 3.7 Å, 349 bp di-nucleosome harboring cohesive DNA termini assembled with linker histone H1.0…
- 6LA2 3.89 Å, 343 bp di-nucleosome harboring cohesive DNA termini assembled with linker histone H1.0
- 8TB9 4.0 Å, PRC2-J119-450 monomer bound to H1-nucleosome
- 9IPU 4.3 Å, cryo-EM structure of the RNF168(1-193)/UbcH5c-Ub ubiquitylation module bound to…
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