6K3B: Lpg2147-Lpg2149 complex

Crystal structure of Lpg2147-Lpg2149 complex. Determined by X-ray diffraction at 1.97 Å resolution. Released 1 Apr 2020.

Method: X-ray diffraction
Resolution: 1.97 Å
Organism: Legionella pneumophila
Chains: 2
Atoms: 4,366
Mol. weight: 56.32 kDa
Released: 1 Apr 2020

Explore 6K3B in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6K3B contains 31 α-helices and 12 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 25 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	10-24	15
α-helix	25-29	5
α-helix	33-44	12
α-helix	45-47	3
α-helix	54-63	10
α-helix	70-71	2
α-helix	74-86	13
α-helix	88-96	9
α-helix	98-99	2
β-strand	100-101	2	1
α-helix	102-103	2
α-helix	107-111	5
β-strand	118-127	10	1
β-strand	132-135	4	2
α-helix	138-140	3
α-helix	147	1
β-strand	150-153	4	2
β-strand	158-161	4	2
β-strand	167-169	3	2
α-helix	174-183	10
α-helix	187-189	3
β-strand	191-193	3	2
α-helix	205-221	17
β-strand	227-237	11	1
α-helix	245-246	2
β-strand	249-251	3	1
β-strand	254	1	3
β-strand	258	1	3
α-helix	260-265	6
α-helix	268-273	6
α-helix	276-289	14
α-helix	293-304	12
α-helix	306	1
α-helix	316-318	3
β-strand	324-332	9	1
α-helix	335-352	18
α-helix	358-380	23

Chain B: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	11-36	26
α-helix	44-53	10
α-helix	61-63	3
α-helix	70-77	8
α-helix	79-82	4
α-helix	92-110	19

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Lpg2147	A	protein	382	Legionella pneumophila	Q5ZTL4 (AlphaFold model)
Uncharacterized protein	B	protein	108	Legionella pneumophila	Q5ZTL2 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6K3B_1 Lpg2147 (chains A)
GSHMEKTGLHVHEKIKHMVKNYGTMITGIPAEILGQNEAEISVGYVKKMGNMKENIAEVV
RKSEMTQPTNSAGKASNEVCDLLLGTEGASEFEKSSYQVLSGDGSNLKGSLPNKNLLVRV
EMDRFNAPQKYQKIKREEFNPETAEKNKIYLLEDQLVYLDIFGKVIDLGQTSDTCHRLFN
AITTPFYQNYILYDEYIDPEESAEEAAMFEMGEIVKAKMKNIDCWTATHSFTIFVPESDS
EDTRTLYPYQAYWTSHTLQQWFSGDKDEKLSRLGIDGYIEKLALLGTTTDSKIRSSIYGE
LFSPPGKEHVFCTGMNEKFSPLRVKFKVTEVNPEIALQNLEEVQEFIDTNYPGENAKDQC
ELYKIKAQEAMTKQLEMRLLIE

Sequence of entity 2 (B), FASTA

>6K3B_2 Uncharacterized protein (chains B)
GSHMFFKDYQKKNVMRLLQDSLEKIINEWLKTDDESHTKLKSLQELSEMDINATSFAEHS
PLPDFVTRLWLDPHKALDAMDKNISKNEIRKLIKETAREIELVFTHQK

Primary citation

Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC. Mu, Y., Wang, Y., Huang, Y. et al. Nat Commun (2020) 11:1774-1774. DOI 10.1038/s41467-020-15645-7 · PubMed

Other PDB entries of the same protein (UniProt Q5ZTL4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6P5H 1.53 Å, Structure of MavC middle insertion domain
6ULH 1.97 Å, Structure of MavC in complex with its substrate in R3 spacegroup
5TSC 2.01 Å, The crystal structure of Lpg2147 from Legionella pneumophila
6P5B 2.1 Å, Crystal Structure of MavC in Complex with Ub-UbE2N
6UMS 2.34 Å, Crystal structure of MavC in complex with its substrate mimic in C222(1) space group
6KG6 2.39 Å, Crystal structure of MavC/UBE2N-Ub complex
7BXH 2.7 Å, MavC-Lpg2149 complex
7BXG 2.71 Å, MavC-UBE2N-Ub complex
6UMP 2.8 Å, Crystal structure of MavC in complex with substrate mimic in P65 space group
6KL4 2.85 Å, Crystal structure of MavC-UBE2N-Ub
6KFP 2.92 Å, Crystal structure of MavC ternary complex

Browse structure collections

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