Solution Structure of the CS1 Domain of USP19. Determined by solution NMR. Released 10 Jun 2020.
Explore 6K7W in 3D Show helices and sheets RCSB PDB PDBe
6K7W contains 1 α-helix and 9 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 119-122 | 4 | 1 |
| β-strand | 126-131 | 6 | 1 |
| α-helix | 140-142 | 3 | |
| β-strand | 143 | 1 | 2 |
| β-strand | 146-148 | 3 | 3 |
| β-strand | 151-154 | 4 | 3 |
| β-strand | 156 | 1 | 2 |
| β-strand | 162-165 | 4 | 3 |
| β-strand | 177-179 | 3 | 1 |
| β-strand | 185-190 | 6 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 19 | A | protein | 92 | Homo sapiens | O94966 (AlphaFold model) |
>6K7W_1 Ubiquitin carboxyl-terminal hydrolase 19 (chains A) TPELALDWRQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQQWGGVFYAEIKS SCAKVQTRKGSLLHLTLPKKVPMLTWPSLLVE
Domain interactions reveal auto-inhibition of the deubiquitinating enzyme USP19 and its activation by HSP90 in the modulation of huntingtin aggregation. Xue, W., Zhang, S.X., He, W.T. et al. Biochem J (2020) 477:4295-4312. DOI 10.1042/BCJ20200536 · PubMed
Other PDB entries of the same protein (UniProt O94966 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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