Protein capicua homolog (CIC) is a 2517-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q96RK0.
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The mean pLDDT of this model is 40.4 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 7% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 88% |
What pLDDT means and how to read it
Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development
Found in a complex with ATXN1 and ATXN1L
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6KZG | X-ray | 2.0 Å | C/Q=1207-1214 |
| 4J2J | X-ray | 2.5 Å | D/E/F=937-957 |
| 6KZH | X-ray | 2.65 Å | C/Q=1079-1086 |
| 7M5W | X-ray | 2.95 Å | A=1097-1189, A=1191-2436 |
| 6JRP | X-ray | 3.0 Å | A/D/G/J=1108-1185 |
| 4J2L | X-ray | 3.15 Å | C/D=932-957 |
| 2M41 | NMR | A=943-957 |
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