CryoEM structure of zebra fish alpha-1 glycine receptor bound with taurine in nanodisc, desensitized state. Determined by electron microscopy at 3.0 Å resolution. Released 6 Jan 2021.
Explore 6PLS in 3D Show helices and sheets RCSB PDB PDBe
6PLS contains 70 α-helices and 75 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 26-34 | 9 | |
| α-helix | 52 | 1 | |
| β-strand | 53-68 | 16 | 1 |
| β-strand | 73-85 | 13 | 1 |
| α-helix | 87-89 | 3 | |
| β-strand | 98-101 | 4 | 1 |
| α-helix | 103-108 | 6 | |
| β-strand | 114-116 | 3 | 2 |
| β-strand | 122-124 | 3 | 1 |
| β-strand | 132-137 | 6 | 1 |
| β-strand | 141-153 | 13 | 1 |
| α-helix | 161-163 | 3 | |
| β-strand | 165-174 | 10 | 2 |
| β-strand | 182-186 | 5 | 1 |
| β-strand | 192-194 | 3 | 1 |
| β-strand | 203-205 | 3 | 2 |
| β-strand | 210-213 | 4 | 2 |
| β-strand | 216-217 | 2 | 3 |
| β-strand | 222-223 | 2 | 3 |
| β-strand | 225-234 | 10 | 2 |
| α-helix | 235 | 1 | |
| α-helix | 237-239 | 3 | |
| α-helix | 240-244 | 5 | |
| α-helix | 245-253 | 9 | |
| α-helix | 255-258 | 4 | |
| α-helix | 265-284 | 20 | |
| α-helix | 285-287 | 3 | |
| α-helix | 300-323 | 24 | |
| α-helix | 391-427 | 37 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Glycine receptor subunit alphaZ1 | A, B, C, D, E | protein | 458 | Danio rerio | O93430 (AlphaFold model) |
>6PLS_1 Glycine receptor subunit alphaZ1 (chains A, B, C, D, E) MFALGIYLWETIVFFSLAASQQAAARKAASPMPPSEFLDKLMGKVSGYDARIRPNFKGPP VNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYSEYPDDSLDLDPSMLDSIWKP DLFFANEKGANFHEVTTDNKLLRISKNGNVLYSIRITLVLACPMDLKNFPMDVQTCIMQL ESFGYTMNDLIFEWDEKGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHL ERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPK VSYVKAIDIWMAVCLLFVFSALLEYAAVNFIARQHKELLRFQRRRRHLKEDEAGDGRFSF AAYGMGPACLQAKDGMAIKGNNNNAPTSTNPPEKTVEEMRKLFISRAKRIDTVSRVAFPL VFLIFNIFYWITYKIIRSEDIHKQLVPRGSHHHHHHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| TAU | 2-aminoethanesulfonic acid | C2 H7 N O3 S | 5 |
Water and common crystallization additives (UNL) are not listed.
Mechanism of gating and partial agonist action in the glycine receptor. Yu, J., Zhu, H., Lape, R. et al. Cell (2021) 184:957-968.e21. DOI 10.1016/j.cell.2021.01.026 · PubMed
Other PDB entries of the same protein (UniProt O93430 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 6PLS directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.