A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-open state. Determined by electron microscopy at 2.8 Å resolution. Released 8 Mar 2023.
Explore 7U2N in 3D Show helices and sheets RCSB PDB PDBe
7U2N contains 50 α-helices and 100 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 26-34 | 9 | |
| α-helix | 37-39 | 3 | |
| β-strand | 54-68 | 15 | 1 |
| β-strand | 73-85 | 13 | 1 |
| α-helix | 87-89 | 3 | |
| α-helix | 103-107 | 5 | |
| β-strand | 114-116 | 3 | 2 |
| β-strand | 122-124 | 3 | 1 |
| β-strand | 132 | 1 | 1 |
| β-strand | 135-136 | 2 | 1 |
| β-strand | 141-143 | 3 | 1 |
| β-strand | 146-153 | 8 | 1 |
| β-strand | 167-168 | 2 | 3 |
| β-strand | 171 | 1 | 4 |
| β-strand | 172-174 | 3 | 2 |
| β-strand | 183-186 | 4 | 1 |
| β-strand | 192 | 1 | 1 |
| β-strand | 203 | 1 | 5 |
| β-strand | 211-213 | 3 | 4 |
| β-strand | 216-218 | 3 | 6 |
| β-strand | 221-223 | 3 | 6 |
| β-strand | 226-228 | 3 | 4 |
| β-strand | 230-231 | 2 | 3 |
| β-strand | 234 | 1 | 5 |
| α-helix | 236-238 | 3 | |
| α-helix | 239-242 | 4 | |
| α-helix | 245-256 | 12 | |
| α-helix | 266-286 | 21 | |
| α-helix | 298-324 | 27 | |
| α-helix | 391-425 | 35 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Glycine receptor subunit alphaZ1 | A, B, C, D, E | protein | 458 | Danio rerio | O93430 (AlphaFold model) |
>7U2N_1 Glycine receptor subunit alphaZ1 (chains A, B, C, D, E) MFALGIYLWETIVFFSLAASQQAAARKAASPMPPSEFLDKLMGKVSGYDARIRPNFKGPP VNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYSEYPDDSLDLDPSMLDSIWKP DLFFANEKGANFHEVTTDNKLLRISKNGNVLYSIRITLVLACPMDLKNFPMDVQTCIMQL ESFGYTMNDLIFEWDEKGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHL ERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPK VSYVKAIDIWMAVCLLFVFSALLEYAAVNFIARQHKELLRFQRRRRHLKEDEAGDGRFSF AAYGMGPACLQAKDGMAIKGNNNNAPTSTNPPEKTVEEMRKLFISRAKRIDTVSRVAFPL VFLIFNIFYWITYKIIRSEDIHKQLVPRGSHHHHHHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| L2L | aminomethanesulfonic acid | C H5 N O3 S | 5 |
A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-open state. Zhu, H., Gouaux, E. To be published.
Other PDB entries of the same protein (UniProt O93430 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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