6PTO: Ctf4 trimer
Structure of Ctf4 trimer in complex with three CMG helicases. Determined by electron microscopy at 7.0 Å resolution. Released 20 Nov 2019.
- Method
- Electron microscopy
- Resolution
- 7.0 Å
- Organism
- Saccharomyces cerevisiae
- Chains
- 36
- Atoms
- 132,192
- Mol. weight
- 2674.62 kDa
- Ligands
- ATP
- Released
- 20 Nov 2019
Explore 6PTO in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
6PTO contains 636 α-helices and 568 β-strands across 36 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains 2, F and h: 25 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 203-216 | 14 | |
| α-helix | 227-236 | 10 | |
| α-helix | 249-254 | 6 | |
| α-helix | 266-280 | 15 | |
| β-strand | 320-327 | 8 | 160 |
| β-strand | 331-333 | 3 | 161 |
| β-strand | 338 | 1 | 162 |
| β-strand | 340 | 1 | 163 |
| β-strand | 350 | 1 | 162 |
| β-strand | 374 | 1 | 163 |
| β-strand | 383-385 | 3 | 161 |
| β-strand | 387-391 | 5 | 160 |
| β-strand | 405-409 | 5 | 160 |
| α-helix | 412-414 | 3 | |
| β-strand | 423-426 | 4 | 160 |
| β-strand | 431 | 1 | 164 |
| α-helix | 442-443 | 2 | |
| β-strand | 450 | 1 | 164 |
| β-strand | 451-452 | 2 | 160 |
| β-strand | 456-457 | 2 | 160 |
| α-helix | 479-486 | 8 | |
| α-helix | 493-497 | 5 | |
| α-helix | 509-520 | 12 | |
| β-strand | 540-541 | 2 | 165 |
| α-helix | 549-559 | 11 | |
| α-helix | 573-576 | 4 | |
| β-strand | 579 | 1 | 166 |
| α-helix | 581-583 | 3 | |
| β-strand | 592 | 1 | 166 |
| α-helix | 613-616 | 4 | |
| α-helix | 617-619 | 3 | |
| α-helix | 621-624 | 4 | |
| α-helix | 663-666 | 4 | |
| α-helix | 671-674 | 4 | |
| β-strand | 680-681 | 2 | 165 |
| α-helix | 689-702 | 14 | |
| α-helix | 738-750 | 13 | |
| α-helix | 760-767 | 8 | |
| α-helix | 784-786 | 3 | |
| α-helix | 787-799 | 13 | |
| α-helix | 807-821 | 15 | |
| α-helix | 834-846 | 13 | |
| α-helix | 854-863 | 10 | |
Chains 3, G and i: 21 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-28 | 10 | |
| α-helix | 33-35 | 3 | |
| α-helix | 41-52 | 12 | |
| α-helix | 101-103 | 3 | |
| α-helix | 109-114 | 6 | |
| α-helix | 122-136 | 15 | |
| β-strand | 165 | 1 | 167 |
| β-strand | 179-186 | 8 | 167 |
| β-strand | 194-203 | 10 | 168 |
| β-strand | 209 | 1 | 168 |
| β-strand | 212-213 | 2 | 168 |
| α-helix | 224-226 | 3 | |
| β-strand | 241-252 | 12 | 168 |
| β-strand | 254-258 | 5 | 167 |
| β-strand | 274-278 | 5 | 167 |
| α-helix | 280-282 | 3 | |
| β-strand | 291-301 | 11 | 167 |
| β-strand | 318-328 | 11 | 167 |
| α-helix | 344-354 | 11 | |
| α-helix | 359-365 | 7 | |
| α-helix | 375-386 | 12 | |
| α-helix | 392-393 | 2 | |
| β-strand | 405 | 1 | 169 |
| β-strand | 406-409 | 4 | 170 |
| α-helix | 417-421 | 5 | |
| α-helix | 448-450 | 3 | |
| α-helix | 483-491 | 9 | |
| β-strand | 495-497 | 3 | 171 |
| β-strand | 504-506 | 3 | 171 |
| β-strand | 513 | 1 | 169 |
| β-strand | 516 | 1 | 170 |
| α-helix | 537-540 | 4 | |
| β-strand | 546-549 | 4 | 170 |
| α-helix | 555-566 | 12 | |
| α-helix | 653-662 | 10 | |
| α-helix | 673-687 | 15 | |
| α-helix | 700-716 | 17 | |
| α-helix | 725-737 | 13 | |
Chains 4, H and j: 28 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 189-199 | 11 | |
| α-helix | 225-234 | 10 | |
| β-strand | 240-243 | 4 | 172 |
| α-helix | 255-261 | 7 | |
| α-helix | 267-284 | 18 | |
| α-helix | 291-293 | 3 | |
| α-helix | 295-297 | 3 | |
| β-strand | 302-305 | 4 | 172 |
| β-strand | 326-334 | 9 | 173 |
| α-helix | 337-340 | 4 | |
| β-strand | 348-349 | 2 | 174 |
| β-strand | 382-383 | 2 | 174 |
| β-strand | 395-401 | 7 | 173 |
| α-helix | 410-412 | 3 | |
| β-strand | 414-419 | 6 | 173 |
| β-strand | 432-442 | 11 | 173 |
| β-strand | 458-467 | 10 | 173 |
| α-helix | 504-514 | 11 | |
| α-helix | 518-525 | 8 | |
| α-helix | 534-544 | 11 | |
| β-strand | 563-566 | 4 | 175 |
| β-strand | 567 | 1 | 176 |
| α-helix | 574-584 | 11 | |
| β-strand | 589-590 | 2 | 175 |
| α-helix | 617-619 | 3 | |
| α-helix | 620-623 | 4 | |
| β-strand | 628-632 | 5 | 175 |
| α-helix | 645-651 | 7 | |
| β-strand | 653-655 | 3 | 177 |
| β-strand | 664-666 | 3 | 177 |
| β-strand | 670-674 | 5 | 175 |
| α-helix | 688-690 | 3 | |
| α-helix | 696-699 | 4 | |
| β-strand | 707 | 1 | 176 |
| α-helix | 714-725 | 12 | |
| α-helix | 746-753 | 8 | |
| α-helix | 764-777 | 14 | |
| α-helix | 796-812 | 17 | |
| α-helix | 822-832 | 11 | |
| α-helix | 833-836 | 4 | |
| α-helix | 857-859 | 3 | |
| α-helix | 861-865 | 5 | |
| α-helix | 872-875 | 4 | |
| α-helix | 883-890 | 8 | |
| α-helix | 908-912 | 5 | |
| β-strand | 917 | 1 | 178 |
| β-strand | 925 | 1 | 178 |
Chains 5, I and k: 23 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 27-35 | 9 | |
| α-helix | 47-55 | 9 | |
| β-strand | 60 | 1 | 179 |
| α-helix | 66-76 | 11 | |
| α-helix | 88-98 | 11 | |
| α-helix | 99-101 | 3 | |
| β-strand | 136 | 1 | 179 |
| β-strand | 160-168 | 9 | 180 |
| α-helix | 170-172 | 3 | |
| β-strand | 175-178 | 4 | 181 |
| β-strand | 181-182 | 2 | 182 |
| β-strand | 189-190 | 2 | 182 |
| β-strand | 193 | 1 | 181 |
| β-strand | 242-243 | 2 | 182 |
| β-strand | 249-251 | 3 | 181 |
| β-strand | 256-260 | 5 | 180 |
| β-strand | 273-277 | 5 | 180 |
| α-helix | 280-282 | 3 | |
| β-strand | 290-297 | 8 | 180 |
| β-strand | 300-301 | 2 | 183 |
| β-strand | 325-326 | 2 | 183 |
| β-strand | 328-332 | 5 | 180 |
| α-helix | 352-361 | 10 | |
| α-helix | 366-373 | 8 | |
| α-helix | 382-393 | 12 | |
| β-strand | 412-415 | 4 | 184 |
| α-helix | 424-432 | 9 | |
| β-strand | 436 | 1 | 185 |
| α-helix | 446-448 | 3 | |
| β-strand | 452-454 | 3 | 186 |
| β-strand | 463-466 | 4 | 186 |
| α-helix | 470-472 | 3 | |
| β-strand | 476 | 1 | 185 |
| β-strand | 479-480 | 2 | 184 |
| α-helix | 489-496 | 8 | |
| β-strand | 501-503 | 3 | 187 |
| β-strand | 512-514 | 3 | 187 |
| β-strand | 520-522 | 3 | 184 |
| α-helix | 530-532 | 3 | |
| β-strand | 552-555 | 4 | 184 |
| α-helix | 564-576 | 13 | |
| α-helix | 580-584 | 5 | |
| α-helix | 596-607 | 12 | |
| α-helix | 616-618 | 3 | |
| α-helix | 619-637 | 19 | |
| α-helix | 653-667 | 15 | |
| α-helix | 674-684 | 11 | |
| α-helix | 686-689 | 4 | |
Chains 6, J and l: 20 helices, 26 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 104-120 | 17 | |
| α-helix | 135-146 | 12 | |
| β-strand | 153-154 | 2 | 188 |
| α-helix | 156-162 | 7 | |
| α-helix | 170-172 | 3 | |
| α-helix | 178-190 | 13 | |
| β-strand | 267-268 | 2 | 188 |
| β-strand | 273-274 | 2 | 189 |
| β-strand | 287 | 1 | 190 |
| β-strand | 289-290 | 2 | 189 |
| β-strand | 293-295 | 3 | 191 |
| β-strand | 301-303 | 3 | 192 |
| β-strand | 354-356 | 3 | 192 |
| β-strand | 357-362 | 6 | 191 |
| β-strand | 378-381 | 4 | 191 |
| β-strand | 394 | 1 | 191 |
| β-strand | 396 | 1 | 193 |
| β-strand | 400 | 1 | 190 |
| β-strand | 401-404 | 4 | 194 |
| β-strand | 451-454 | 4 | 194 |
| β-strand | 455-456 | 2 | 191 |
| β-strand | 460 | 1 | 193 |
| α-helix | 512-519 | 8 | |
| α-helix | 525-531 | 7 | |
| α-helix | 541-551 | 11 | |
| α-helix | 581-591 | 11 | |
| β-strand | 597-598 | 2 | 195 |
| α-helix | 612 | 1 | |
| β-strand | 613 | 1 | 196 |
| α-helix | 614-615 | 2 | |
| β-strand | 616 | 1 | 197 |
| β-strand | 619 | 1 | 197 |
| β-strand | 622 | 1 | 196 |
| β-strand | 637-639 | 3 | 195 |
| α-helix | 648-657 | 10 | |
| β-strand | 661-663 | 3 | 198 |
| β-strand | 670-672 | 3 | 198 |
| β-strand | 680-681 | 2 | 195 |
| α-helix | 695-698 | 4 | |
| α-helix | 704-707 | 4 | |
| α-helix | 714-716 | 3 | |
| α-helix | 723-732 | 10 | |
| α-helix | 748-758 | 11 | |
| α-helix | 769-784 | 16 | |
| α-helix | 799-813 | 15 | |
| α-helix | 823-838 | 16 | |
Chains 7, K and m: 23 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 8-10 | 3 | |
| α-helix | 15-22 | 8 | |
| α-helix | 62-71 | 10 | |
| β-strand | 80-81 | 2 | 199 |
| α-helix | 83-90 | 8 | |
| α-helix | 102-108 | 7 | |
| α-helix | 110-112 | 3 | |
| α-helix | 115-121 | 7 | |
| α-helix | 122-124 | 3 | |
| α-helix | 141-151 | 11 | |
| α-helix | 152-154 | 3 | |
| α-helix | 191-193 | 3 | |
| β-strand | 204-205 | 2 | 199 |
| β-strand | 238-244 | 7 | 200 |
| β-strand | 246 | 1 | 200 |
| β-strand | 254-255 | 2 | 201 |
| β-strand | 260-261 | 2 | 202 |
| β-strand | 269 | 1 | 202 |
| α-helix | 296-298 | 3 | |
| β-strand | 299-300 | 2 | 202 |
| β-strand | 307-308 | 2 | 201 |
| β-strand | 313-314 | 2 | 200 |
| α-helix | 327-328 | 2 | |
| β-strand | 332-334 | 3 | 200 |
| β-strand | 348-356 | 9 | 200 |
| β-strand | 375-381 | 7 | 200 |
| α-helix | 398-407 | 10 | |
| α-helix | 413-417 | 5 | |
| α-helix | 426-433 | 8 | |
| β-strand | 456-459 | 4 | 203 |
| α-helix | 467-474 | 8 | |
| β-strand | 481-482 | 2 | 203 |
| β-strand | 496-497 | 2 | 204 |
| β-strand | 508-509 | 2 | 204 |
| β-strand | 520-522 | 3 | 203 |
| α-helix | 530-541 | 12 | |
| β-strand | 546-547 | 2 | 205 |
| β-strand | 556-557 | 2 | 205 |
| β-strand | 562-567 | 6 | 203 |
| α-helix | 606-621 | 16 | |
| α-helix | 635-645 | 11 | |
| α-helix | 655-674 | 20 | |
| α-helix | 686-702 | 17 | |
| α-helix | 710-723 | 14 | |
Chains a, A and n: 7 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-23 | 20 | |
| α-helix | 34-57 | 24 | |
| α-helix | 66-103 | 38 | |
| α-helix | 118-121 | 4 | |
| α-helix | 128-143 | 16 | |
| α-helix | 157-158 | 2 | |
| β-strand | 163-165 | 3 | 206 |
| β-strand | 166-167 | 2 | 207 |
| β-strand | 189-191 | 3 | 206 |
| α-helix | 197-200 | 4 | |
| β-strand | 205-207 | 3 | 207 |
Chains b, B and o: 7 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 16-20 | 5 | |
| β-strand | 24-26 | 3 | 7 |
| β-strand | 27-29 | 3 | 8 |
| β-strand | 70-72 | 3 | 7 |
| α-helix | 73-81 | 9 | |
| β-strand | 85-87 | 3 | 8 |
| α-helix | 88-90 | 3 | |
| α-helix | 95-106 | 12 | |
| α-helix | 119-125 | 7 | |
| α-helix | 143-161 | 19 | |
| β-strand | 170 | 1 | 9 |
| α-helix | 175-197 | 23 | |
6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| DNA polymerase alpha-binding protein | X, Y, Z | protein | 927 | Saccharomyces cerevisiae | Q01454 (AlphaFold model) |
| DNA replication complex GINS protein PSF1 | A, a, n | protein | 208 | Saccharomyces cerevisiae | Q12488 (AlphaFold model) |
| DNA replication complex GINS protein PSF2 | B, b, o | protein | 213 | Saccharomyces cerevisiae | P40359 (AlphaFold model) |
| DNA replication complex GINS protein PSF3 | C, c, p | protein | 194 | Saccharomyces cerevisiae | Q12146 (AlphaFold model) |
| DNA replication complex GINS protein SLD5 | D, d, q | protein | 294 | Saccharomyces cerevisiae | Q03406 |
| Cell division control protein 45 | E, e, r | protein | 650 | Saccharomyces cerevisiae | Q08032 |
| DNA replication licensing factor MCM2 | 2, F, h | protein | 868 | Saccharomyces cerevisiae | P29469 |
| DNA replication licensing factor MCM3 | 3, G, i | protein | 971 | Saccharomyces cerevisiae | P24279 |
| DNA replication licensing factor MCM4 | 4, H, j | protein | 933 | Saccharomyces cerevisiae | P30665 |
| Minichromosome maintenance protein 5 | 5, I, k | protein | 775 | Saccharomyces cerevisiae | P29496 |
| DNA replication licensing factor MCM6 | 6, J, l | protein | 1017 | Saccharomyces cerevisiae | P53091 |
| DNA replication licensing factor MCM7 | 7, K, m | protein | 845 | Saccharomyces cerevisiae | P38132 |
Sequence of entity 1 (X, Y, Z), FASTA
>6PTO_1 DNA polymerase alpha-binding protein (chains X, Y, Z)
MVSVIDKLVFDFGGKTLVSLAPDNNTLCVANKNGLTKILKTNNPEEEPETLDSSKLVSSI
KCYSNSHFLMTTMQGDALRYNIDSSQEELLARFALPLRDCCVIHSGKMAVFGGDDLELIL
LELDDETHKKHAIKIDEQVSQISYNSQMNILAVSMINGKVQIFSLTSTIPNKVHELNDYI
VANSYDDTHRDKILSNMMDDIDKDNDNDLSETADPDENNVADPEFCAANRICTRVAWHPK
GLHFALPCADDTVKIFSIKGYSLQKTLSTNLSSTKAHFIDLQFDPLRGTYIAAVDLNNKL
TVWNWETSEIHYTREFKRKITNIAWKIQADSKTLDLVLGTWSGSIAIVQNLAESVVSNIP
DQSVAESSTKHGLFVDSESDLENLEGNDDINKSDKLFSDITQEANAEDVFTQTHDGPSGL
SEKRKYNFEDEEDFIDDDDGAGYISGKKPHNEHSYSRVHKTHSFPISLANTGKFRYMPFS
PAGTPFGFTDRRYLTMNEVGYVSTVKNSEQYSITVSFFDVGRFREYHFEDLFGYDLCFLN
EKGTLFGQSKTGQIQYRPHDSIHSNWTKIIPLQAGERITSVAATPVRVIVGTSLGYFRSF
NQFGVPFAVEKTSPIVALTAQNYRVFSVHYSQFHGLSYSLSELGTSSKRYYKRECPLPMS
LPNINSDMKKDANLDYYNFNPMGIKSLFFSSYGDPCIFGSDNTLLLLSKWRSPEESKWLP
ILDSNMEIWKMSGGKETTDIHVWPLALAYDTLNCILVKGKHIWPEFPLPLPSEMEIRMPV
FVKSKLLEENKAILNKKNEIGADTEAEEGEEDKEIQIPVSMAAEEEYLRSKVLSELLTDT
LENDGEMYGNENEVLAALNGAYDKALLRLFASACSDQNVEKALSLAHELKQDRALTAAVK
ISERAELPSLVKKINNIREARYEQQLK
Sequence of entity 2 (A, a, n), FASTA
>6PTO_2 DNA replication complex GINS protein PSF1 (chains A, a, n)
MYGDLGNKLVLEAKRTKQLYARSNQDVNLPMYHEDIIRNILKEVSNLRKNTEYLKEQQQL
GMLDDKVAKCQYFVTLLCMERNKRCLLAYQRLRTDILDSMAWNNNGLDLMSSITFSQQDT
NNLSHQEQEYLKEYCDLITDLKSGDLVDIDLSGSLVPPSDVFIDVRVLKDAGEIQTEYGV
FNLIKDSQFFVRQSDVERLIQQGYLQKI
Sequence of entity 3 (B, b, o), FASTA
>6PTO_3 DNA replication complex GINS protein PSF2 (chains B, b, o)
MSLPAHLQQTFSPEEIQFIVENEPIKIFPRITTRQKIRGDDRGTGNHTRWQLITTDDKAL
NNMVAMRSTEVVLWIALLLKQQSKCSIVAPQWLTTKELDRKIQYEKTHPDRFSELPWNWL
VLARILFNKAKDDFHDPIHELRGKIQDLREIRQIKVLKGLKYLNESHLQLDNLSLLEINE
LRPFITEIMDKLREIHTASLTAGTENDEEEFNI
Sequence of entity 4 (C, c, p), FASTA
>6PTO_4 DNA replication complex GINS protein PSF3 (chains C, c, p)
MGYYDIDDVLADGTEFPCKFQYDIPGLGYLENNPGRPITKNTKLSLPLWLARILAIVGGD
EALVDEEPVPFVELLPPDMFSTKVMNAIKTDPVALDLHSINSHFFSLAIKWIMLFSEKEL
ANVVSELLLQRAQELNHHASSLSIDLNADSTGKNSANTNIATSTFLLKLEEMEKEIYKKS
HESYKDTKRWMFKK
Sequence of entity 5 (D, d, q), FASTA
>6PTO_5 DNA replication complex GINS protein SLD5 (chains D, d, q)
MDINIDDILAELDKETTAVDSTKITQGSSSTTHRDANTIVGSSLDLNDKTQIYVSPQQDF
SDLMKSWKNERCSPELLPYPHQLMKRLLNRISMQSQLIENISMGFLDMQNASNANPPMPN
ESKLPLLCMETELERLKFVIRSYIRCRLSKIDKFSLYLRQLNEDENSLISLTDLLSKDEI
KYHDTHSLIWLKLVNDSILKYMPEELQAINDTEGSVNMIDEPDWNKFVFIHVNGPPDGKW
NEDPLLQENEFGKPCYTVTIPDLKEEVELTIGSIYVMRYEVIRDLLRDDKVALI
Sequence of entity 6 (E, e, r), FASTA
>6PTO_6 Cell division control protein 45 (chains E, e, r)
MYYGISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVP
IFGYSELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDI
YVLDAHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYKLLELDEESGDDELSGDEND
NNGGDDEATDADEVTDEDEEDEDETISNKRGNSSIGPNDLSKRKQRKKQIHEYEGVLEEY
YSQGTTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAYAQVYNRLYPLLQDEVK
RLTPSSRNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNENGKKRLH
KMFARMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTLGYRGSIS
ASEFVEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRWVSNFWLS
WDALDDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDGPDLDLYR
NPLTLLRLGNWLIECCAESEDKQLLPMVLASIDENTDTYLVAGLTPRYPRGLDTIHTKKP
ILNNFSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLL
Sequence of entity 7 (2, F, h), FASTA
>6PTO_7 DNA replication licensing factor MCM2 (chains 2, F, h)
MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPD
IDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERD
RLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREE
LTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSE
SLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDF
PTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIR
ISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKP
GEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEE
EREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVL
LLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLAD
KGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNST
LPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELK
NNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQ
MDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKV
VVDSFVDAQKVSVRRQLRRSFAIYTLGH
Sequence of entity 8 (3, G, i), FASTA
>6PTO_8 DNA replication licensing factor MCM3 (chains 3, G, i)
MEGSTGFDGDATTFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQ
DDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAY
FIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLV
SVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNK
LTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKS
LGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIF
DILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLR
FVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTD
VDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLL
SRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINP
EEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYV
QYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKT
VNKVDAKVAANLLRFALLGEDIGNDIDEEESEYEEALSKRSPQKSPKKRQRVRQPASNSG
SPIKSTPRRSTASSVNATPSSARRILRFQDDEQNAGEDDNDIMSPLPADEEAELQRRLQL
GLRVSPRRREHLHAPEEGSSGPLTEVGTPRLPNVSSAGQDDEQQQSVISFDNVEPGTIST
GRLSLISGIIARLMQTEIFEEESYPVASLFERINEELPEEEKFSAQEYLAGLKIMSDRNN
LMVADDKVWRV
Sequence of entity 9 (4, H, j), FASTA
>6PTO_9 DNA replication licensing factor MCM4 (chains 4, H, j)
MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGEG
NIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSS
SSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRII
WGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSN
LNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKF
YKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEI
DRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVY
DELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTST
IEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGI
LLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVG
LTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAG
IITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDREL
AKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKM
GDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDP
KTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQDRVES
SDIQEALSRLQQEDKVIVLGEGVRRSVRLNNRV
Sequence of entity 10 (5, I, k), FASTA
>6PTO_10 Minichromosome maintenance protein 5 (chains 5, I, k)
MSFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYS
LTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENT
SMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLS
IMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDP
YIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSI
YNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQL
SRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGT
AKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCID
EFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNI
DFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMK
RYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRIT
ESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQELKR
RLPIGWSTSYQTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYRSGV
Sequence of entity 11 (6, J, l), FASTA
>6PTO_11 DNA replication licensing factor MCM6 (chains 6, J, l)
MSSPFPADTPSSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGP
FVNDSTQFSSQRLQTDGSATNDMEGNEPARSFKSRALNHVKKVDDVTGEKVREAFEQFLE
DFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPF
LQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGN
GTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEV
RPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVR
IQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSST
LDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRET
ELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGH
EAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSG
KASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQT
ISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCN
EKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKEL
RKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDV
DDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKK
KTTVTYDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRL
AFKVIKRLVKDRILMEIHGTRHNLRDLENEENENNKTVYVIHPNCEVLDQLEPQDSS
Sequence of entity 12 (7, K, m), FASTA
>6PTO_12 DNA replication licensing factor MCM7 (chains 7, K, m)
MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKG
PKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRA
IDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDA
LREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLIT
VRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFM
STRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPY
TGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAP
EIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRG
VYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEV
MEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLM
LDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYV
VQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLV
RVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLS
NCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDI
DLQDA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 6 |
Primary citation
Ctf4 organizes sister replisomes and Pol alpha into a replication factory. Yuan, Z., Georgescu, R., Santos, R.L.A. et al. Elife (2019) 8. DOI 10.7554/eLife.47405 · PubMed
Other PDB entries of the same protein (UniProt Q01454 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5NXQ 2.41 Å, Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to a stapled Sld5 CIP
- 4C8H 2.69 Å, Crystal structure of the C-terminal region of yeast Ctf4, selenomethionine protein.
- 4C93 2.69 Å, Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Pol alpha.
- 4C95 2.69 Å, Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Sld5
- 4C8S 3.0 Å, Crystal structure of the C-terminal region of yeast Ctf4
- 8KG6 3.07 Å, Yeast replisome in state I
- 5HOG 3.09 Å, Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Dna2.
- 7PMK 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
- 7PMN 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
- 5HOI 3.3 Å, Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Tof2.
- 8B9A 3.5 Å, S. cerevisiae replisome + Ctf4, bound by pol alpha primase. Complex engaged with a fork…
- 8B9B 3.5 Å, S. cerevisiae replisome + Ctf4, bound by pol alpha. Complex engaged with a fork DNA…
Browse structure collections
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