8KG6: Yeast replisome in state I

Name: PDB 8KG6: Yeast replisome in state I
Published: 2023-12-06
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: replication

Yeast replisome in state I. Determined by electron microscopy at 3.07 Å resolution. Released 6 Dec 2023.

Method: Electron microscopy
Resolution: 3.07 Å
Organisms: Saccharomyces cerevisiae S288C, Saccharomyces cerevisiae
Chains: 20
Atoms: 70,613
Mol. weight: 1655.4 kDa
Ligands: ZN, ADP, MG, AGS
Released: 6 Dec 2023

Explore 8KG6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8KG6 contains 393 α-helices and 392 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 2: 34 helices, 32 β-strands

Element	Residues	Length	Sheet
α-helix	183-187	5
α-helix	194-199	6
α-helix	201-217	17
β-strand	219	1	1
β-strand	225	1	1
α-helix	226-236	11
β-strand	241-245	5	2
α-helix	246-251	6
α-helix	254-262	9
α-helix	264-282	19
α-helix	286-288	3
β-strand	294-298	5	2
α-helix	311-313	3
β-strand	317-318	2	3
β-strand	321-327	7	3
β-strand	331-334	4	4
β-strand	336-337	2	5
β-strand	339-341	3	6
β-strand	351-352	2	5
α-helix	353	1
β-strand	373-375	3	6
β-strand	382-385	4	4
β-strand	386-391	6	3
α-helix	398	1
α-helix	402-404	3
β-strand	405-410	6	3
β-strand	423-433	11	3
α-helix	436-442	7
β-strand	446	1	7
β-strand	448-458	11	3
α-helix	478-488	11
α-helix	493-499	7
α-helix	509-520	12
β-strand	526-527	2	8
β-strand	531-532	2	8
β-strand	539-543	5	9
α-helix	549-559	11
β-strand	563-567	5	9
β-strand	571	1	10
α-helix	573-576	4
β-strand	578-582	5	11
β-strand	589-593	5	11
α-helix	595-598	4
β-strand	603-607	5	9
α-helix	609-611	3
α-helix	614-617	4
α-helix	618-620	3
α-helix	621-625	5
β-strand	630-633	4	12
β-strand	636-639	4	12
β-strand	646-650	5	9
α-helix	653-655	3
α-helix	663-665	3
α-helix	671-674	4
β-strand	679-683	5	9
β-strand	686	1	13
α-helix	689-705	17
α-helix	740-755	16
α-helix	760-773	14
β-strand	777	1	14
α-helix	783-798	16
α-helix	807-823	17
β-strand	828	1	14
α-helix	831-847	17
α-helix	851-861	11
α-helix	862-864	3

Chain 3: 29 helices, 36 β-strands

Element	Residues	Length	Sheet
α-helix	19-34	16
α-helix	36-54	19
β-strand	95-99	5	15
α-helix	100-106	7
α-helix	108-116	9
α-helix	118-135	18
β-strand	154-158	5	15
β-strand	159	1	16
α-helix	162-164	3
β-strand	165-166	2	17
α-helix	173-175	3
β-strand	179-189	11	17
α-helix	190-192	3
β-strand	195-203	9	18
β-strand	208-213	6	18
α-helix	225-227	3
β-strand	234	1	19
β-strand	240	1	19
β-strand	242-243	2	18
β-strand	249-251	3	18
β-strand	253	1	20
β-strand	256-259	4	17
α-helix	262-264	3
α-helix	266	1
α-helix	270-272	3
β-strand	273-276	4	17
β-strand	279	1	20
α-helix	280-282	3
β-strand	291-301	11	17
β-strand	318-327	10	17
β-strand	330	1	21
β-strand	336	1	21
α-helix	344-354	11
α-helix	359-365	7
α-helix	375-385	11
α-helix	387-390	4
β-strand	391	1	22
β-strand	399	1	22
β-strand	405-409	5	23
α-helix	415-425	11
β-strand	429-433	5	23
β-strand	437	1	24
α-helix	439-442	4
β-strand	444-448	5	25
β-strand	455-459	5	25
β-strand	469-473	5	23
α-helix	475-477	3
α-helix	480-482	3
α-helix	484-492	9
β-strand	494-497	4	26
β-strand	504-507	4	26
β-strand	511-516	6	23
β-strand	518	1	27
β-strand	533	1	27
α-helix	537-540	4
β-strand	545-549	5	23
α-helix	556-569	14
β-strand	592	1	16
α-helix	653-666	14
β-strand	670	1	28
α-helix	673-687	15
α-helix	691-693	3
α-helix	700-715	16
β-strand	720	1	28
α-helix	723-737	15

Chain 4: 27 helices, 35 β-strands

Element	Residues	Length	Sheet
α-helix	187-198	12
α-helix	203-209	7
α-helix	225-236	12
β-strand	244	1	29
α-helix	246-250	5
α-helix	255-263	9
α-helix	265-287	23
α-helix	293-298	6
β-strand	306	1	29
α-helix	314-316	3
β-strand	324-335	12	30
β-strand	339-344	6	31
β-strand	347-349	3	32
β-strand	355-356	2	32
β-strand	359	1	31
β-strand	361	1	33
β-strand	364	1	33
β-strand	370	1	34
β-strand	379	1	34
β-strand	382-384	3	32
α-helix	386-388	3
β-strand	390-394	5	31
β-strand	397-401	5	30
α-helix	411-412	2
β-strand	414-418	5	30
β-strand	420	1	31
β-strand	432-441	10	30
β-strand	444-445	2	35
β-strand	453-454	2	35
β-strand	459-467	9	30
α-helix	503-513	11
α-helix	518-526	9
α-helix	534-545	12
β-strand	564-566	3	36
α-helix	573-584	12
β-strand	591-592	2	37
β-strand	604-607	4	38
α-helix	610-612	3
β-strand	614-617	4	38
β-strand	628-630	3	36
β-strand	631-632	2	37
α-helix	634-636	3
α-helix	639-651	13
β-strand	653-658	6	39
β-strand	661-666	6	39
β-strand	670-674	5	36
α-helix	688-692	5
α-helix	696-699	4
β-strand	704-706	3	36
α-helix	714-730	17
α-helix	747-757	11
β-strand	761-762	2	40
α-helix	764-779	16
α-helix	795-810	16
β-strand	816-817	2	40
α-helix	819-836	18
α-helix	852-873	22
β-strand	881	1	41
α-helix	883-888	6
α-helix	900-912	13
β-strand	916-918	3	41
β-strand	924-926	3	41

Chain 5: 32 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	21-37	17
α-helix	45-55	11
β-strand	60-64	5	42
α-helix	65-71	7
α-helix	73-81	9
α-helix	83-102	20
α-helix	133-135	3
β-strand	136-140	5	42
α-helix	144-147	4
α-helix	148-150	3
β-strand	159-169	11	43
α-helix	170-172	3
β-strand	173-183	11	44
β-strand	190-193	4	44
β-strand	241-243	3	44
β-strand	249-253	5	44
β-strand	255-259	5	43
β-strand	273-277	5	43
α-helix	280-282	3
β-strand	291-301	11	43
β-strand	323	1	4
β-strand	325-333	9	43
α-helix	351-361	11
α-helix	366-372	7
α-helix	382-393	12
β-strand	398-399	2	45
β-strand	405-406	2	45
β-strand	412-416	5	46
α-helix	422-432	11
β-strand	436-440	5	46
β-strand	444	1	12
α-helix	446-449	4
β-strand	451-455	5	47
β-strand	462-466	5	47
α-helix	468-471	4
β-strand	476-480	5	46
α-helix	482-484	3
α-helix	487-490	4
α-helix	493-498	6
β-strand	501-506	6	24
β-strand	509-514	6	24
β-strand	518-522	5	46
α-helix	536-539	4
α-helix	544-549	6
β-strand	552-556	5	46
α-helix	562-576	15
α-helix	579-590	12
α-helix	596-609	14
β-strand	613-614	2	48
α-helix	616-640	25
α-helix	650-666	17
β-strand	671-672	2	48
α-helix	674-684	11
α-helix	685-689	5
α-helix	690-692	3
α-helix	708-721	14
β-strand	727-729	3	49
α-helix	730-736	7
α-helix	750-757	8
β-strand	762-763	2	49
β-strand	769-771	3	49

Chain 6: 31 helices, 30 β-strands

Element	Residues	Length	Sheet
α-helix	106-121	16
α-helix	135-146	12
β-strand	150-154	5	50
α-helix	155-160	6
α-helix	161-164	4
α-helix	165-172	8
α-helix	174-192	19
α-helix	260-263	4
β-strand	264-268	5	50
α-helix	281-283	3
β-strand	287-288	2	7
β-strand	291-297	7	7
β-strand	301-311	11	7
β-strand	317-322	6	7
β-strand	344-346	3	7
β-strand	352-362	11	7
α-helix	365-367	3
α-helix	369	1
α-helix	373-375	3
β-strand	376-382	7	7
α-helix	383-385	3
β-strand	394-405	12	7
α-helix	407-410	4
β-strand	437	1	51
β-strand	438	1	33
β-strand	448	1	51
β-strand	450-461	12	7
α-helix	501-506	6
α-helix	510-520	11
α-helix	525-531	7
α-helix	541-552	12
β-strand	558	1	52
α-helix	563	1
β-strand	564	1	52
α-helix	565-566	2
β-strand	571-575	5	53
α-helix	581-591	11
β-strand	596-599	4	54
β-strand	610-614	5	55
β-strand	621-625	5	55
α-helix	627-630	4
β-strand	635-639	5	54
α-helix	646-649	4
α-helix	652-657	6
β-strand	660-664	5	10
β-strand	669-673	5	10
β-strand	677-678	2	54
β-strand	679-680	2	53
β-strand	681	1	54
α-helix	683-684	2
α-helix	695-698	4
α-helix	703-706	4
β-strand	711-715	5	53
α-helix	721-736	16
α-helix	748-759	12
β-strand	764-765	2	56
α-helix	767-783	17
β-strand	791	1	13
α-helix	797-813	17
β-strand	818-819	2	56
α-helix	821-832	12

Chain 7: 29 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	8	1	18
α-helix	14-26	13
α-helix	62-71	10
β-strand	77-81	5	57
α-helix	82-93	12
α-helix	102-106	5
α-helix	110-123	14
α-helix	126-128	3
α-helix	138-154	17
α-helix	194-197	4
β-strand	201-205	5	57
α-helix	206-207	2
α-helix	213-215	3
β-strand	225	1	58
α-helix	227-229	3
α-helix	232-234	3
β-strand	238-245	8	58
β-strand	252-262	11	58
β-strand	268-272	5	58
β-strand	277-278	2	35
α-helix	287-292	6
β-strand	298-299	2	58
β-strand	306-316	11	58
α-helix	323	1
β-strand	330-336	7	58
β-strand	348-358	11	58
α-helix	364-368	5
β-strand	371	1	18
β-strand	373-383	11	58
α-helix	396-407	12
α-helix	410-418	9
α-helix	426-437	12
β-strand	456-458	3	59
α-helix	466-476	11
β-strand	481-484	4	59
β-strand	497	1	60
β-strand	509	1	60
β-strand	520-524	5	59
α-helix	531-543	13
β-strand	545-547	3	61
β-strand	556-558	3	61
α-helix	561	1
β-strand	562-566	5	59
α-helix	580-583	4
α-helix	588-592	5
β-strand	596-598	3	59
α-helix	608-622	15
α-helix	636-648	13
α-helix	650-653	4
α-helix	654-674	21
α-helix	686-702	17
α-helix	710-726	17

Chain A: 6 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	4-21	18
α-helix	34-60	27
α-helix	65-104	40
α-helix	120-122	3
α-helix	125-144	20
β-strand	162-166	5	62
β-strand	167	1	63
β-strand	172-175	4	64
β-strand	180-183	4	64
β-strand	188-192	5	62
α-helix	197-202	6
β-strand	205	1	63

Chain B: 10 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	5-7	3
α-helix	13-20	8
β-strand	24-27	4	65
α-helix	58-61	4
β-strand	69-72	4	65
α-helix	73-81	9
β-strand	87	1	65
α-helix	88-90	3
α-helix	91-93	3
α-helix	95-107	13
α-helix	119-129	11
α-helix	138-157	20
β-strand	169	1	66
α-helix	175-199	25

10 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA replication licensing factor MCM2	2	protein	868	Saccharomyces cerevisiae S288C	P29469 (AlphaFold model)
DNA replication licensing factor MCM3	3	protein	971	Saccharomyces cerevisiae S288C	P24279 (AlphaFold model)
DNA replication licensing factor MCM4	4	protein	933	Saccharomyces cerevisiae S288C	P30665 (AlphaFold model)
Minichromosome maintenance protein 5	5	protein	775	Saccharomyces cerevisiae S288C	P29496 (AlphaFold model)
DNA replication licensing factor MCM6	6	protein	1017	Saccharomyces cerevisiae S288C	P53091
DNA replication licensing factor MCM7	7	protein	845	Saccharomyces cerevisiae S288C	P38132
DNA replication complex GINS protein PSF1	A	protein	208	Saccharomyces cerevisiae S288C	Q12488
DNA replication complex GINS protein PSF2	B	protein	213	Saccharomyces cerevisiae S288C	P40359
DNA replication complex GINS protein PSF3	C	protein	194	Saccharomyces cerevisiae S288C	Q12146
DNA replication complex GINS protein SLD5	D	protein	294	Saccharomyces cerevisiae S288C	Q03406
Cell division control protein 45	E	protein	650	Saccharomyces cerevisiae S288C	Q08032
DNA polymerase alpha-binding protein	F, G, H	protein	927	Saccharomyces cerevisiae S288C	Q01454

6 more molecules are not listed.

Sequence of entity 1 (2), FASTA

>8KG6_1 DNA replication licensing factor MCM2 (chains 2)
MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPD
IDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERD
RLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREE
LTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSE
SLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDF
PTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIR
ISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKP
GEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEE
EREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVL
LLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLAD
KGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNST
LPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELK
NNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQ
MDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKV
VVDSFVDAQKVSVRRQLRRSFAIYTLGH

Sequence of entity 2 (3), FASTA

>8KG6_2 DNA replication licensing factor MCM3 (chains 3)
MEGSTGFDGDATTFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQ
DDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAY
FIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLV
SVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNK
LTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKS
LGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIF
DILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLR
FVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTD
VDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLL
SRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINP
EEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYV
QYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKT
VNKVDAKVAANLLRFALLGEDIGNDIDEEESEYEEALSKRSPQKSPKKRQRVRQPASNSG
SPIKSTPRRSTASSVNATPSSARRILRFQDDEQNAGEDDNDIMSPLPADEEAELQRRLQL
GLRVSPRRREHLHAPEEGSSGPLTEVGTPRLPNVSSAGQDDEQQQSVISFDNVEPGTIST
GRLSLISGIIARLMQTEIFEEESYPVASLFERINEELPEEEKFSAQEYLAGLKIMSDRNN
LMVADDKVWRV

Sequence of entity 3 (4), FASTA

>8KG6_3 DNA replication licensing factor MCM4 (chains 4)
MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGEG
NIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSS
SSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRII
WGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSN
LNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKF
YKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEI
DRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVY
DELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTST
IEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGI
LLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVG
LTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAG
IITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDREL
AKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKM
GDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDP
KTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQDRVES
SDIQEALSRLQQEDKVIVLGEGVRRSVRLNNRV

Sequence of entity 4 (5), FASTA

>8KG6_4 Minichromosome maintenance protein 5 (chains 5)
MSFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYS
LTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENT
SMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLS
IMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDP
YIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSI
YNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQL
SRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGT
AKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCID
EFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNI
DFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMK
RYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRIT
ESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQELKR
RLPIGWSTSYQTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYRSGV

Sequence of entity 5 (6), FASTA

>8KG6_5 DNA replication licensing factor MCM6 (chains 6)
MSSPFPADTPSSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGP
FVNDSTQFSSQRLQTDGSATNDMEGNEPARSFKSRALNHVKKVDDVTGEKVREAFEQFLE
DFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPF
LQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGN
GTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEV
RPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVR
IQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSST
LDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRET
ELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGH
EAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSG
KASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQT
ISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCN
EKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKEL
RKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDV
DDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKK
KTTVTYDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRL
AFKVIKRLVKDRILMEIHGTRHNLRDLENEENENNKTVYVIHPNCEVLDQLEPQDSS

Sequence of entity 6 (7), FASTA

>8KG6_6 DNA replication licensing factor MCM7 (chains 7)
MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKG
PKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRA
IDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDA
LREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLIT
VRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFM
STRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPY
TGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAP
EIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRG
VYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEV
MEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLM
LDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYV
VQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLV
RVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLS
NCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDI
DLQDA

Sequence of entity 7 (A), FASTA

>8KG6_7 DNA replication complex GINS protein PSF1 (chains A)
MYGDLGNKLVLEAKRTKQLYARSNQDVNLPMYHEDIIRNILKEVSNLRKNTEYLKEQQQL
GMLDDKVAKCQYFVTLLCMERNKRCLLAYQRLRTDILDSMAWNNNGLDLMSSITFSQQDT
NNLSHQEQEYLKEYCDLITDLKSGDLVDIDLSGSLVPPSDVFIDVRVLKDAGEIQTEYGV
FNLIKDSQFFVRQSDVERLIQQGYLQKI

Sequence of entity 8 (B), FASTA

>8KG6_8 DNA replication complex GINS protein PSF2 (chains B)
MSLPAHLQQTFSPEEIQFIVENEPIKIFPRITTRQKIRGDDRGTGNHTRWQLITTDDKAL
NNMVAMRSTEVVLWIALLLKQQSKCSIVAPQWLTTKELDRKIQYEKTHPDRFSELPWNWL
VLARILFNKAKDDFHDPIHELRGKIQDLREIRQIKVLKGLKYLNESHLQLDNLSLLEINE
LRPFITEIMDKLREIHTASLTAGTENDEEEFNI

Sequence of entity 9 (C), FASTA

>8KG6_9 DNA replication complex GINS protein PSF3 (chains C)
MGYYDIDDVLADGTEFPCKFQYDIPGLGYLENNPGRPITKNTKLSLPLWLARILAIVGGD
EALVDEEPVPFVELLPPDMFSTKVMNAIKTDPVALDLHSINSHFFSLAIKWIMLFSEKEL
ANVVSELLLQRAQELNHHASSLSIDLNADSTGKNSANTNIATSTFLLKLEEMEKEIYKKS
HESYKDTKRWMFKK

Sequence of entity 10 (D), FASTA

>8KG6_10 DNA replication complex GINS protein SLD5 (chains D)
MDINIDDILAELDKETTAVDSTKITQGSSSTTHRDANTIVGSSLDLNDKTQIYVSPQQDF
SDLMKSWKNERCSPELLPYPHQLMKRLLNRISMQSQLIENISMGFLDMQNASNANPPMPN
ESKLPLLCMETELERLKFVIRSYIRCRLSKIDKFSLYLRQLNEDENSLISLTDLLSKDEI
KYHDTHSLIWLKLVNDSILKYMPEELQAINDTEGSVNMIDEPDWNKFVFIHVNGPPDGKW
NEDPLLQENEFGKPCYTVTIPDLKEEVELTIGSIYVMRYEVIRDLLRDDKVALI

Sequence of entity 11 (E), FASTA

>8KG6_11 Cell division control protein 45 (chains E)
MYYGISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVP
IFGYSELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDI
YVLDAHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYKLLELDEESGDDELSGDEND
NNGGDDEATDADEVTDEDEEDEDETISNKRGNSSIGPNDLSKRKQRKKQIHEYEGVLEEY
YSQGTTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAYAQVYNRLYPLLQDEVK
RLTPSSRNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNENGKKRLH
KMFARMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTLGYRGSIS
ASEFVEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRWVSNFWLS
WDALDDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDGPDLDLYR
NPLTLLRLGNWLIECCAESEDKQLLPMVLASIDENTDTYLVAGLTPRYPRGLDTIHTKKP
ILNNFSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLL

Sequence of entity 12 (F, G, H), FASTA

>8KG6_12 DNA polymerase alpha-binding protein (chains F, G, H)
MVSVIDKLVFDFGGKTLVSLAPDNNTLCVANKNGLTKILKTNNPEEEPETLDSSKLVSSI
KCYSNSHFLMTTMQGDALRYNIDSSQEELLARFALPLRDCCVIHSGKMAVFGGDDLELIL
LELDDETHKKHAIKIDEQVSQISYNSQMNILAVSMINGKVQIFSLTSTIPNKVHELNDYI
VANSYDDTHRDKILSNMMDDIDKDNDNDLSETADPDENNVADPEFCAANRICTRVAWHPK
GLHFALPCADDTVKIFSIKGYSLQKTLSTNLSSTKAHFIDLQFDPLRGTYIAAVDLNNKL
TVWNWETSEIHYTREFKRKITNIAWKIQADSKTLDLVLGTWSGSIAIVQNLAESVVSNIP
DQSVAESSTKHGLFVDSESDLENLEGNDDINKSDKLFSDITQEANAEDVFTQTHDGPSGL
SEKRKYNFEDEEDFIDDDDGAGYISGKKPHNEHSYSRVHKTHSFPISLANTGKFRYMPFS
PAGTPFGFTDRRYLTMNEVGYVSTVKNSEQYSITVSFFDVGRFREYHFEDLFGYDLCFLN
EKGTLFGQSKTGQIQYRPHDSIHSNWTKIIPLQAGERITSVAATPVRVIVGTSLGYFRSF
NQFGVPFAVEKTSPIVALTAQNYRVFSVHYSQFHGLSYSLSELGTSSKRYYKRECPLPMS
LPNINSDMKKDANLDYYNFNPMGIKSLFFSSYGDPCIFGSDNTLLLLSKWRSPEESKWLP
ILDSNMEIWKMSGGKETTDIHVWPLALAYDTLNCILVKGKHIWPEFPLPLPSEMEIRMPV
FVKSKLLEENKAILNKKNEIGADTEAEEGEEDKEIQIPVSMAAEEEYLRSKVLSELLTDT
LENDGEMYGNENEVLAALNGAYDKALLRLFASACSDQNVEKALSLAHELKQDRALTAAVK
ISERAELPSLVKKINNIREARYEQQLK

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	7
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	2
MG	Magnesium ion	Mg	5
AGS	Phosphothiophosphoric acid-adenylate ester	C10 H16 N5 O12 P3 S	3

Primary citation

Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Xu, Z., Feng, J., Yu, D. et al. Nat Commun (2023) 14:5849-5849. DOI 10.1038/s41467-023-41506-0 · PubMed

Other PDB entries of the same protein (UniProt P29469 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7W8G 2.52 Å, Cryo-EM structure of MCM double hexamer
28VY 2.7 Å, sCMGE assembled on ARS1 DNA with Sld2 and RPA
8RIF 2.79 Å, Cryo-EM structure of the MCM double hexamer loaded onto dsDNA.
7V3V 2.9 Å, Cryo-EM structure of MCM double hexamer bound with DDK in State I
9TH8 2.9 Å, Cryo-EM structure of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA
7P30 3.0 Å, 3.0 A resolution structure of a DNA-loaded MCM double hexamer
9RHL 3.1 Å, Phospho-DH bound by Sld3-MBD on ARS1 DNA
7PMK 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
7PMN 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
7PT6 3.2 Å, Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III
7V3U 3.2 Å, Cryo-EM structure of MCM double hexamer with structured Mcm4-NSD
9E2Y 3.2 Å, Cryo-EM structure of yeast CMG helicase stalled at G4-containing DNA template, state 3

Browse structure collections

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