6QG8: Human Bcl-2

Structure of human Bcl-2 in complex with PUMA BH3 peptide. Determined by X-ray diffraction at 1.9 Å resolution. Released 12 Jun 2019.

Method: X-ray diffraction
Resolution: 1.9 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,419
Mol. weight: 23.19 kDa
Released: 12 Jun 2019

Explore 6QG8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6QG8 contains 10 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 0 β-strands

Element	Residues	Length
α-helix	12-24	13
α-helix	49-107	17
α-helix	109-118	10
α-helix	123-137	15
α-helix	144-163	20
α-helix	169-180	12
α-helix	181-185	5
α-helix	186-190	5
α-helix	194-202	9

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	130-146	17

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1	A	protein	177	Homo sapiens	P10415 (AlphaFold model)
Bcl-2-binding component 3	B	protein	23	Homo sapiens	Q9BXH1 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6QG8_1 Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1 (chains A)
MSQDNREIVMKYISYKLSQRGYEWDAGDVEENRTEAPEGTESEVVHQTLRQAGDDFSLRY
RRDFAEMSSQLHLTPGTAYASFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSV
LVDNIAAWMATYLNDHLHTWIQDNGGWDAFVELYGNNAAAESRKGQERFLEHHHHHH

Sequence of entity 2 (B), FASTA

>6QG8_2 Bcl-2-binding component 3 (chains B)
RGEEEQWAREIGAQLRRMADDLN

Primary citation

Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1. Murray, J.B., Davidson, J., Chen, I. et al. ACS Omega (2019) 4:8892-8906. DOI 10.1021/acsomega.9b00611 · PubMed

Other PDB entries of the same protein (UniProt P10415 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8HTS 1.25 Å, Crystal structure of Bcl2 in complex with S-10r
6GL8 1.4 Å, Crystal structure of Bcl-2 in complex with the novel orally active inhibitor S55746
6QGG 1.5 Å, Structure of human Bcl-2 in complex with analogue of ABT-737
9IGG 1.5 Å, Structure of human Bcl-xL in complex with small molecule inhibitor
8HTR 1.6 Å, Crystal structure of Bcl2 in complex with S-9c
6O0K 1.62 Å, crystal structure of BCL-2 with venetoclax
9I9E 1.7 Å, Structure of human Bcl-xL in complex with small molecule inhibitor
9O14 1.73 Å, Crystal Structure of BCL-2 in complex with a stapled BAD BH3 peptide BAD SAHB 4.2
9O16 1.73 Å, Crystal Structure of human BCL-2 (R129L) mutant in complex with a stapled BAD BH3…
6O0M 1.75 Å, crystal structure of BCL-2 F104L mutation with venetoclax
5VAU 1.75 Å, Bcl-2 complex with Beclin 1 BH3 domain
8VWX 1.77 Å, Human Bcl-2 (G101V Mutant)/Bcl-xL Chimera Fused to Maltose-Binding Protein

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