6SZ5: Human calmodulin

Human calmodulin bound to a peptide of human NADPH oxidase 5. Determined by X-ray diffraction at 2.23 Å resolution. Released 11 Dec 2019.

Method: X-ray diffraction
Resolution: 2.23 Å
Organism: Homo sapiens
Chains: 3
Atoms: 1,362
Mol. weight: 181.25 kDa
Ligands: CA
Released: 11 Dec 2019

Explore 6SZ5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6SZ5 contains 9 α-helices and 4 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	7-20	14
β-strand	27-28	2	1
α-helix	30-39	10
α-helix	46-54	9
β-strand	64-65	2	1
α-helix	66-93	28
β-strand	100-101	2	2
α-helix	103-112	10
α-helix	119-129	11
β-strand	137-138	2	2
α-helix	139-145	7

Chains B and C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	648-655	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin-2	A	protein	149	Homo sapiens	P0DP24 (AlphaFold model)
NADPH oxidase 5	B, C	protein	719	Homo sapiens	Q96PH1 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6SZ5_1 Calmodulin-2 (chains A)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B, C), FASTA

>6SZ5_2 NADPH oxidase 5 (chains B, C)
MSAEEDARWLRWVTQQFKTIAGEDGEISLQEFKAALHVKESFFAERFFALFDSDRSGTIT
LQELQEALTLLIHGSPMDKLKFLFQVYDIDGSGSIDPDELRTVLQSCLRESAISLPDEKL
DQLTLALFESADADGNGAITFEELRDELQRFPGVMENLTISAAHWLTAPAPRPRPRRPRQ
LTRAYWHNHRSQLFCLATYAGLHVLLFGLAASAHRDLGASVMVAKGCGQCLNFDCSFIAV
LMLRRCLTWLRATWLAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTVNFVLQAQAEASP
FQFWELLLTTRPGIGWVHGSASPTGVALLLLLLLMFICSSSCIRRSGHFEVFYWTHLSYL
LVWLLLIFHGPNFWKWLLVPGILFFLEKAIGLAVSRMAAVCIMEVNLLPSKVTHLLIKRP
PFFHYRPGDYLYLNIPTIARYEWHPFTISSAPEQKDTIWLHIRSQGQWTNRLYESFKASD
PLGRGSKRLSRSVTMRKSQRSSKGSEILLEKHKFCNIKCYIDGPYGTPTRRIFASEHAVL
IGAGIGITPFASILQSIMYRHQKRKHTCPSCQHSWIEGVQDNMKLHKVDFIWINRDQRSF
EWFVSLLTKLEMDQAEEAQYGRFLELHMYMTSALGKNDMKAIGLQMALDLLANKEKKDSI
TGLQTRTQPGRPDWSKVFQKVAAEKKGKVQVFFCGSPALAKVLKGHCEKFGFRFFQENF

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

On the mechanism of calcium-dependent activation of NADPH oxidase 5 (NOX5). Millana Fananas, E., Todesca, S., Sicorello, A. et al. FEBS J (2020) 287:2486-2503. DOI 10.1111/febs.15160 · PubMed

Other PDB entries of the same protein (UniProt P0DP24 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6XXF 1.7 Å, 1.7 Angstrom crystal structure of Ca/CaM:RyR2 peptide complex
3O77 2.35 Å, The structure of Ca2+ Sensor (Case-16)
8KA0 2.35 Å, Crystal structure of Vibrio vulnificus RID-dependent transforming NADase domain…
7MIR 2.5 Å, Cryo-EM structure of SidJ-SdeA-CaM reaction intermediate complex
6PLM 2.59 Å, Legionella pneumophila SidJ/ Calmodulin 2 complex
3O78 2.6 Å, The structure of Ca2+ Sensor (Case-12)
5COC 2.67 Å, Fusion protein of human calmodulin and B4 domain of protein A from staphylococcal aureus
6MUD 2.69 Å, Voltage-gated sodium channel NaV1.5 C-terminal domain in complex with Ca2+/Calmodulin
7MIS 2.8 Å, Cryo-EM structure of SidJ-SdeC-CaM reaction intermediate complex
8KA1 2.82 Å, Crystal structure of Vibrio vulnificus RID-dependent transforming NADase domain…
8K9Z 2.9 Å, Crystal structure of Vibrio vulnificus RID-dependent transforming NADase domain…
7PPO 2.91 Å, Structure of SidJ/CaM bound to SdeA in pre-glutamylation state

Browse structure collections

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