Structure of GCP6 in the native human gamma-tubulin ring complex. Determined by electron microscopy at 4.5 Å resolution. Released 1 Jan 2020.
Explore 6V6C in 3D Show helices and sheets RCSB PDB PDBe
6V6C contains 24 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 353-356 | 4 | |
| α-helix | 393-411 | 19 | |
| α-helix | 427-446 | 20 | |
| α-helix | 456-462 | 7 | |
| α-helix | 464-476 | 13 | |
| α-helix | 499-511 | 13 | |
| α-helix | 518-528 | 11 | |
| α-helix | 530-539 | 10 | |
| α-helix | 589-605 | 17 | |
| α-helix | 1478-1503 | 26 | |
| α-helix | 1505-1515 | 11 | |
| α-helix | 1524-1534 | 11 | |
| α-helix | 1553-1557 | 5 | |
| α-helix | 1558-1561 | 4 | |
| β-strand | 1573 | 1 | 1 |
| β-strand | 1597 | 1 | 1 |
| α-helix | 1602-1605 | 4 | |
| α-helix | 1612-1639 | 28 | |
| α-helix | 1641-1643 | 3 | |
| α-helix | 1653-1678 | 26 | |
| α-helix | 1679-1683 | 5 | |
| α-helix | 1684-1686 | 3 | |
| α-helix | 1699-1714 | 16 | |
| α-helix | 1723-1741 | 19 | |
| α-helix | 1762-1784 | 23 | |
| α-helix | 1796-1802 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Gamma-tubulin complex component 6 | L | protein | 1819 | Homo sapiens | Q96RT7 (AlphaFold model) |
>6V6C_1 Gamma-tubulin complex component 6 (chains L) MASITQLFDDLCEALLPAAKTHLGQRSVNRKRAKRSLKKVAYNALFTNLFQDETQQLQPD MSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEVGSVLDLLVQLAGS GPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQ VMEAAPGTGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNAD LSGLAIKVPPSVDQWEDEGFQSASNLTPDSQSEPSVTPDVDLWEAALTYEASKRRCWERV GCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAPQPVLVKECELVKDVLNVL IGVVSATFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPVLD SLYSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVG AVLPGTCGGGPRAAFPTGVKLLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWV YSGVFRDAYGEFMIQVNHEYLSFRDKLYWTHGYVLISKEVEDCVPVFLKHIAHDIYVCGK TINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEE KELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERR QAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALW RIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGG QGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFL PVGPGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPA VATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQ PTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTH GHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSNA SIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGE SVSDMAPTRPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSDVV STRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSTVLDCGPR LPVEVGPSLSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGDSVSEELGPGRSGDTEDL SPNWPLNSQEDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSE PPIAHLLRPVLPRAFAFPVDPQVQSAADETAVQLSELLTLPVLMKRSITAPLAAHISLVN KAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNS VLSKALQCSLHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGC VSKYSGVFSFLLQLKLMMWALKDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVI QGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSI FSLVLKFRSQLISQAWGPPGGPRGAEHPNFALMQQSYNTFKYYSHFLFKVVTKLVNRGYQ PHLEDFLLRINFNNYYQDA
Asymmetric Molecular Architecture of the Human gamma-Tubulin Ring Complex. Wieczorek, M., Urnavicius, L., Ti, S.C. et al. Cell (2020) 180:165-175.e16. DOI 10.1016/j.cell.2019.12.007 · PubMed
Other PDB entries of the same protein (UniProt Q96RT7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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