Structure of TRPA1 (ligand-free) with bound calcium, LMNG. Determined by electron microscopy at 3.1 Å resolution. Released 6 May 2020.
Explore 6V9W in 3D Show helices and sheets RCSB PDB PDBe
6V9W contains 156 α-helices and 20 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 448-454 | 7 | |
| α-helix | 459-465 | 7 | |
| α-helix | 485-492 | 8 | |
| α-helix | 495-504 | 10 | |
| α-helix | 512-514 | 3 | |
| α-helix | 517-524 | 8 | |
| α-helix | 527-533 | 7 | |
| α-helix | 551-557 | 7 | |
| α-helix | 561-569 | 9 | |
| α-helix | 583-589 | 7 | |
| α-helix | 593-601 | 9 | |
| α-helix | 605-609 | 5 | |
| α-helix | 622-629 | 8 | |
| α-helix | 631-641 | 11 | |
| β-strand | 642-643 | 2 | 1 |
| β-strand | 656-659 | 4 | 1 |
| α-helix | 666-668 | 3 | |
| α-helix | 680-681 | 2 | |
| α-helix | 684-691 | 8 | |
| α-helix | 695-698 | 4 | |
| α-helix | 701-710 | 10 | |
| α-helix | 711-715 | 5 | |
| α-helix | 716-739 | 24 | |
| β-strand | 746 | 1 | 2 |
| β-strand | 751 | 1 | 2 |
| α-helix | 767-794 | 28 | |
| α-helix | 799-801 | 3 | |
| α-helix | 804-819 | 16 | |
| α-helix | 820-822 | 3 | |
| α-helix | 828-849 | 22 | |
| α-helix | 857-872 | 16 | |
| α-helix | 874-891 | 18 | |
| α-helix | 896-898 | 3 | |
| α-helix | 901-910 | 10 | |
| α-helix | 919-923 | 5 | |
| α-helix | 924-926 | 3 | |
| α-helix | 934-946 | 13 | |
| α-helix | 947-952 | 6 | |
| α-helix | 953-967 | 15 | |
| α-helix | 968-970 | 3 | |
| α-helix | 971-987 | 17 | |
| α-helix | 992-998 | 7 | |
| β-strand | 1002-1005 | 4 | 1 |
| α-helix | 1041-1070 | 30 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily A member 1 | A, B, C, D | protein | 1119 | Homo sapiens | O75762 (AlphaFold model) |
>6V9W_1 Transient receptor potential cation channel subfamily A member 1 (chains A, B, C, D) MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA VGDIADVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 4 |
Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Zhao, J., Lin King, J.V., Paulsen, C.E. et al. Nature (2020) 585:141-145. DOI 10.1038/s41586-020-2480-9 · PubMed
Other PDB entries of the same protein (UniProt O75762 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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