6WW4: HERC2 ZZ domain

Crystal structure of HERC2 ZZ domain in complex with histone H3 tail. Determined by X-ray diffraction at 2.25 Å resolution. Released 5 Aug 2020.

Method: X-ray diffraction
Resolution: 2.25 Å
Organism: Homo sapiens
Chains: 2
Atoms: 973
Mol. weight: 13.5 kDa
Ligands: ZN
Released: 5 Aug 2020

Explore 6WW4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6WW4 contains 3 α-helices and 10 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	3-6	4
β-strand	2702-2703	2	3
β-strand	2716-2717	2	3
β-strand	2720-2723	4	4
β-strand	2730-2731	2	4
α-helix	2733-2738	6
β-strand	2747-2750	4	4

Chain B: 1 helix, 5 β-strands

Element	Residues	Length	Sheet
β-strand	2702-2703	2	1
β-strand	2716-2717	2	1
β-strand	2720-2723	4	2
β-strand	2730-2731	2	2
α-helix	2733-2738	6
β-strand	2747-2750	4	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Histone H3.1,E3 ubiquitin-protein ligase HERC2	A, B	protein	56	Homo sapiens	O95714, P68431 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>6WW4_1 Histone H3.1,E3 ubiquitin-protein ligase HERC2 (chains A, B)
ARTKQTIHPGVTCDGCQMFPINGSRFKCRNCDDFDFCETCFKTKKHNTRHTFGRIN

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	4

Water and common crystallization additives (GOL) are not listed.

Primary citation

Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1. Liu, J., Xue, Z., Zhang, Y. et al. Structure (2020) 28:1225-1230.e3. DOI 10.1016/j.str.2020.07.003 · PubMed

Other PDB entries of the same protein (UniProt O95714), best resolution first:

9L93 1.73 Å, Crystal structure of NCOA4 in complex with HERC2
3KCI 1.8 Å, The third RLD domain of HERC2
9L8Y 1.92 Å, Crystal structure of HERC2
7Q42 1.95 Å, Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with…
7RGW 1.99 Å, Crystal structure of HERC2 DOC domain
6WW3 2.1 Å, Crystal structure of HERC2 ZZ domain in complex with SUMO1 tail
7Q45 2.1 Å, Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with…
7Q44 2.2 Å, Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with…
7Q40 2.35 Å, Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2
7Q43 2.4 Å, Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with…
7Q46 2.46 Å, Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with…
4L1M 2.6 Å, Structure of the first RCC1-like domain of HERC2

Browse structure collections

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